Patents by Inventor Mikko Unkila
Mikko Unkila has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10377791Abstract: The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R6 are as defined in the claims. The invention further relates to their use as inhibitors of 17?-HSD and in treatment or prevention of steroid hormone de-pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17?-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.Type: GrantFiled: June 25, 2014Date of Patent: August 13, 2019Assignee: FORENDO PHARMA LTD.Inventors: Maire Eloranta, Leena Hirvelä, Lauri Kangas, Pasi Koskimies, Risto Lammintausta, Mikko Unkila
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Patent number: 9850272Abstract: The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2, R3, R4, R7 and R8 are as defined in the claims. The invention further relates to their use as inhibitors of 17?-HSD1 and in treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17?-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.Type: GrantFiled: June 25, 2014Date of Patent: December 26, 2017Assignee: FORENDO PHARMA LTD.Inventors: Leena Hirvelä, Lauri Kangas, Pasi Koskimies, Risto Lammintausta, Mikko Unkila
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Patent number: 9663549Abstract: The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2 to R7 are as defined in the claims. The invention further relates to their use as inhibitors of 17?-HSD and in treatment or prevention of steroid hormone de-pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17?-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the afore-mentioned compounds or pharmaceutically acceptable salts thereof.Type: GrantFiled: June 25, 2014Date of Patent: May 30, 2017Assignee: FORENDO PHARMA LTD.Inventors: Maire Eloranta, Leena Hirvelä, Lauri Kangas, Pasi Koskimies, Risto Lammintausta, Mikko Unkila
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Publication number: 20170114090Abstract: The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R1 to R6 are as defined in the claims. The invention further relates to their use as inhibitors of 17?-HSD and in treatment or prevention of steroid hormone de-pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17?-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 25, 2014Publication date: April 27, 2017Applicant: FORENDO PHARMA LTDInventors: Maire ELORANTA, Leena HIRVELÄ, Lauri KANGAS, Pasi KOSKIMIES, Risto Lammintausta, Mikko Unkila
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Publication number: 20170081357Abstract: The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2 to R7 are as defined in the claims. The invention further relates to their use as inhibitors of 17?-HSD and in treatment or prevention of steroid hormone de-pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17?-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the afore-mentioned compounds or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 25, 2014Publication date: March 23, 2017Applicant: FORENDO PHARMA LTDInventors: Maire ELORANTA, Leena HIRVELÄ, Lauri KANGAS, Pasi KOSKIMIES, Risto LAMMINTAUSTA, Mikko UNKILA
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Publication number: 20170081356Abstract: The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2, R3, R4, R7 and R8 are as defined in the claims. The invention further relates to their use as inhibitors of 17?-HSD1 and in treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17?-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.Type: ApplicationFiled: June 25, 2014Publication date: March 23, 2017Applicant: FORENDO PHARMA LTDInventors: Leena HIRVELÄ, Lauri KANGAS, Pasi KOSKIMIES, Risto LAMMINTAUSTA, Mikko UNKILA
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Patent number: 8288367Abstract: Substituted estratriene compounds of formula (I) useful in therapy, especially in the treatment or inhibition of a steroid hormone dependent disorder requiring the inhibition of a 17?-hydroxysteroid dehydrogenase (17?-HSD) type 1, type 2 and/or type 3 enzyme, as well as their salts, pharmaceutical compositions containing such compounds and processes for preparing such compounds.Type: GrantFiled: November 29, 2007Date of Patent: October 16, 2012Assignee: Solvay Pharmaceuticals GmBHInventors: Josef Messinger, Uwe Schoen, Heinrich-Hubert Thole, Bettina Husen, Pasi Koskimies, Mikko Unkila
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Patent number: 7582677Abstract: A topical formulation which includes a lignan or lignan ester in a dermatologically acceptable vehicle. The formulation can be either a cosmetic formulation or a pharmaceutical formulation.Type: GrantFiled: May 15, 2003Date of Patent: September 1, 2009Assignee: Hormos Medical Corp.Inventors: Helena Korte, Veli-Matti Lehtola, Mikko Unkila, Mervi Hiilovaara-Teijo, Markku Ahotupa
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Patent number: 7528166Abstract: Novel phenolic esters of lignans, and pharmaceutical compositions, dietary supplements, and food products containing these esters.Type: GrantFiled: January 21, 2003Date of Patent: May 5, 2009Assignee: Hormos Medical CorporationInventors: Patrik Eklund, Mervi Hiilovaara-Teijo, Arja Kalapudas, Lauri Kangas, Anna Lindholm, Rainer Sjohölm, Marja Södervall, Mikko Unkila
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Patent number: 7524853Abstract: Thiophenepyrimidinone compounds and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring inhibition of 17?-hydroxysteroid dehydrogenase enzymes.Type: GrantFiled: December 15, 2004Date of Patent: April 28, 2009Assignees: Solvay Pharmaceuticals B.V., Solvay Pharmaceuticals GmbHInventors: Leena Hirvelae, Nina Johansson, Pasi Koskimies, Olli Taneli Pentikaeinen, Tommi Nyroenen, Tiina Annamaria Salminen, Mark Stuart Johnson, Pekka Lehtovuori, Pauli Saarenketo, Bartholomeus Johannes Van Steen, Heinrich-Hubert Thole, Mikko Unkila, Josef Messinger, Johanna Kiviniemi, Lila Pirkkala, Bettina Husen
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Publication number: 20080255075Abstract: Substituted estratriene compounds of formula (I) useful in therapy, especially in the treatment or inhibition of a steroid hormone dependent disorder requiring the inhibition of a 17?-hydroxysteroid dehydrogenase (17?-HSD) type 1, type 2 and/or type 3 enzyme, as well as their salts, pharmaceutical compositions containing such compounds and processes for preparing such compounds.Type: ApplicationFiled: November 29, 2007Publication date: October 16, 2008Applicant: Solvay Pharmaceuticals GmbHInventors: Josef MESSINGER, Uwe Schoen, Heinrich-Hubert Thole, Bettina Husen, Pasi Koskimies, Mikko Unkila
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Publication number: 20080057140Abstract: The use of a lignan, which is a plant lignan, a metabolite thereof or a combination of both, for the manufacture of a composition for preventing or alleviating of symptoms relating to estrogen deficiency in an individual. Also disclosed is the use of a plant lignan capable of being a precursor for enterolactone or another metabolite of the plant lignan, for the manufacture of a composition useful for increasing the level of enterolactone or another metabolite of a plant lignan in an individual's serum, where the individual suffers from or is at risk of estrogen deficiency.Type: ApplicationFiled: November 17, 2005Publication date: March 6, 2008Inventor: Mikko Unkila
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Patent number: 7008666Abstract: The invention relates to a method of inhibiting myeloperoxidase activity in neutrophils in an individual by administering to the individual an effective amount of a lignan, where said lignan is enterolactone. The invention is further directed to a method inhibiting myeloperoxidase activity or oxidative burst of macrophages in an individual by administering to the individual an effective amount of a lignan where said lignan is enterolactone or hydroxymatairesinol or a mixture. Finally, the invention is directed to a method of inhibiting oxidative burst or myeloperoxidase activity in neutrophils in an individual by administering to the individual an effective amount of a lignan which is hydroxymatairesinol.Type: GrantFiled: November 26, 2001Date of Patent: March 7, 2006Assignee: Hormos Nutraceutical Oy Ltd.Inventors: Markku Ahotupa, John Eriksson, Lauri Kangas, Mikko Unkila, Janne Komi, Merja Perälä, Helena Korte
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Publication number: 20050249857Abstract: An inclusion complex of a lignan or lignan ester with a cyclodextrin. Also disclosed are food products, dietary supplements and pharmaceutical compositions containing the complex.Type: ApplicationFiled: June 24, 2003Publication date: November 10, 2005Inventors: Tomi Jarvinen, Pekka Jarho, Mikko Unkila, Mervi Hiilovaara
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Publication number: 20050176742Abstract: Thiophenepyrimidinone compounds and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring inhibition of 17?-hydroxysteroid dehydrogenase enzymes.Type: ApplicationFiled: December 15, 2004Publication date: August 11, 2005Applicants: Solvay Pharmaceuticals B.V., Solvay Pharmaceuticals GmbHInventors: Leena Hirvelae, Nina Johansson, Pasi Koskimies, Olli Pentikaeinen, Tommi Nyroenen, Tiina Salminen, Mark Johnson, Pekka Lehtovuori, Pauli Saarenketo, Bartholomeus Van Steen, Heinrich-Hubert Thole, Mikko Unkila, Josef Messinger, Johanna Kiviniemi, Lila Pirkkala, Bettina Husen
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Publication number: 20050169947Abstract: A topical formulation which includes a lignan or lignan ester in a dermatologically acceptable vehicle. The formulation can be either a cosmetic formulation or a pharmaceutical formulation.Type: ApplicationFiled: May 15, 2003Publication date: August 4, 2005Inventors: Helena Korte, Veli-Matti Lehtola, Mikko Unkila, Mervi Hiilovaara-Jeigo, Markku Ahotupa
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Publication number: 20050101541Abstract: Novel phenolic esters of lignans, and pharmaceutical compositions, dietary supplements, and food products containing these esters.Type: ApplicationFiled: January 21, 2003Publication date: May 12, 2005Inventors: Patrik Eklund, Mervi Hiilovaara-Teijo, Arja Kalapudas, Lauri Kangas, Anna Lindholm, Rainer Sjoholm, Marja Sodervall, Mikko Unkila
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Publication number: 20030144216Abstract: Methods for prevention of cancers, precancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person suffering from coeliac disease, based on administering of a lignan to the person. A method for increasing the level of enterolactone or another metabolite of a lignan in a person's serum is also disclosed, where the person suffers from coeliac disease, thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in the person, based on administering of a lignan to the person.Type: ApplicationFiled: January 25, 2002Publication date: July 31, 2003Inventor: Mikko Unkila
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Publication number: 20030100514Abstract: This invention relates to a method of inhibiting the overactivity of phagocytes or lymphocytes in an individual by administering to said individual an effective amount of a lignan, whereinType: ApplicationFiled: November 26, 2001Publication date: May 29, 2003Inventors: Markku Ahotupa, John Eriksson, Lauri Kangas, Mikko Unkila, Janne Komi, Merja Perala, Helena Korte