Abstract: A bone biopsy instrument kit includes a hollow body having a socketed forward end to receive one of several hollow, disposable needles. A chuck holds a needle in place on the body, and the rear end of the body has a recess for receiving a bushing into which a stylet is threaded for extending through the body and the needle as desired. The stylet serves as an obturator closing the needle for passing through soft tissue to the bone, then the body is used to drive the needle into the bone to a depth that can be checked by reinserting the obturator. The removed specimen material is set inside the disposable needle, and then another stylet with a blunt end is used to extrude the specimen from the needle for diagnosis.