Patents by Inventor Milan Mrksich
Milan Mrksich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7172905Abstract: A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula: Surf-L—Q—T, where —T comprises a reactant ligand, and Surf- designates where the moiety attaches to the surface. The substrate can be made into a protein chip by the reaction of a reactant ligand and a fusion polypeptide, where the fusion polypeptide includes a capture polypeptide moiety which corresponds to the reactant ligand.Type: GrantFiled: August 7, 2001Date of Patent: February 6, 2007Assignee: The University of ChicagoInventors: Milan Mrksich, Christian Hodneland
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Publication number: 20070009668Abstract: The invention provides methods and apparatus for encapsulating particles. An inverted selective withdrawal technique is employed. Two immiscible fluids are added to a container, a first fluid is an aqueous pre-polymer solution with a crosslinking reagent and a second fluid is denser highly viscous fluid. A selective withdrawal tube pulls particles suspended in the first fluid through the second fluid. The particles retain a thin coating of the first fluid. The coated particles are then subjected to a crosslinking process where the pre-polymer solution of the first fluid surrounding the particles is converted into a hydrogel capsule.Type: ApplicationFiled: November 18, 2004Publication date: January 11, 2007Inventors: Jason Wyman, Marc Garfinkel, Sidney Nagel, Milan Mrksich, William Dillmore
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Publication number: 20060138083Abstract: The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface.Type: ApplicationFiled: September 8, 2005Publication date: June 29, 2006Inventors: Declan Ryan, Babak Amirparviz, Vincent Linder, Vincent Semetey, Samuel Sia, Jing Su, Milan Mrksich, George Whitesides
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Patent number: 6972196Abstract: Alkanethiols of formula (1) and the enantiomers of the alkanethiol of formula (1): HS-L-Q-T??(1), and disulfides of formula (3) and the enantiomers of the disulfide of formula (3): T-Q-L S-S-J??(3), where -T is a moiety of formula (2) R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.Type: GrantFiled: October 11, 2000Date of Patent: December 6, 2005Assignee: Arch Development CorporationInventors: Milan Mrksich, Yan-Yeung Luk
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Publication number: 20050255582Abstract: Alkanethiols of formula (1) and the enantimomers of the alkanethiol of formula (1): HS-L-Q-T??(1), and disulfides of formula (3) and the enantimomers of the disulfide of formula (3): T-Q-L-S—S-J??(3), where -T is a moiety of formula (2) R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.Type: ApplicationFiled: May 6, 2005Publication date: November 17, 2005Inventors: Milan Mrksich, Yan-Yeung Luk
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Publication number: 20040178523Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface.Type: ApplicationFiled: October 1, 2003Publication date: September 16, 2004Applicant: President and Fellows of Harvard CollegeInventors: Enoch Kim, Younan Xia, Milan Mrksich, Rebecca J. Jackman, Xiao-Mei Zhao, Stephen P. Smith, Mara G. Prentiss, George M. Whitesides, Christian Marzolin
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Publication number: 20040159633Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding.Type: ApplicationFiled: February 11, 2004Publication date: August 19, 2004Applicant: President & Fellows of Harvard UniversityInventors: George M. Whitesides, Younan Xia, James L. Wilbur, Rebecca J. Jackman, Enoch Kim, Mara G. Prentiss, Milan Mrksich, Amit Kumar, Christopher B. Gorman, Hans Biebuyck, Karl K. Berggren
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Patent number: 6764768Abstract: An alkanethiol of formula (1): HS—L—Q1—T—Q2—M—G—Z (1), may for a SAM. Under application of a potential to the surface, the leaving group —Z is released.Type: GrantFiled: February 28, 2001Date of Patent: July 20, 2004Assignee: Arch Development CorporationInventors: Milan Mrksich, Christian Hodneland
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Method of forming articles including waveguides via capillary micromolding and microtransfer molding
Patent number: 6752942Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface.Type: GrantFiled: October 30, 2001Date of Patent: June 22, 2004Assignee: President and Fellows of Harvard CollegeInventors: Enoch Kim, Younan Xia, Milan Mrksich, Rebecca J. Jackman, Xiao-Mei Zhao, Stephen P. Smith, Mara G. Prentiss, George M. Whitesides, Christian Marzolin -
Patent number: 6660192Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface.Type: GrantFiled: August 9, 2000Date of Patent: December 9, 2003Inventors: Enoch Kim, Younan Xia, Milan Mrksich, Rebecca J. Jackman, Xiao-Mei Zhao, Stephen P. Smith, Mara G. Prentiss, George M. Whitesides, Christian Marzolin
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Publication number: 20030119054Abstract: A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface.Type: ApplicationFiled: August 7, 2001Publication date: June 26, 2003Inventors: Milan Mrksich, Christian Hodneland
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Patent number: 6558665Abstract: Particles such as islet cells are encapsulated by a method that forms a coating of uniform thickness that conforms to the size and shape of the particles. Two substantially immiscible liquids of different densities are provided in a container as upper and lower liquids such that an interface exists between the liquids. The upper liquid is less dense and has a greater viscosity than the lower liquid which is a coating liquid containing particles to be encapsulated. A tube is positioned in the upper liquid such that an orifice of the tube is above the interface. A pump connected to the tube sucks liquid through the tube at a rate sufficient to form a spout containing substantially the lower liquid extending between the interface and the tube orifice. The spout has maximum diameter at the interface and decreases in diameter as the spout approaches the tube orifice.Type: GrantFiled: May 18, 2000Date of Patent: May 6, 2003Assignee: Arch Development CorporationInventors: Itai Cohen, Sidney Nagel, Horacio Rilo, Milan Mrksich
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Patent number: 6518168Abstract: A technique for creating patterns of material deposited on a surface involves forming a self-assembled monolayer in a pattern on the surface and depositing, via chemical vapor deposition or via sol-gel processing, a material on the surface in a pattern complementary to the self-assembled monolayer pattern. The material can be a metal, metal oxide, or the like. The surface can be contoured, including trenches or holes, the trenches or holes remaining free of self-assembled monolayer while the remainder of the surface is coated. When exposed to deposition conditions, metal or metal oxide is deposited in the trenches or holes, and remaining portions of the article surface remain free of deposition. The technique finds particular use in creation of conductive metal pathways selectively within holes passing from one side of a substrate to another.Type: GrantFiled: November 2, 1998Date of Patent: February 11, 2003Assignees: President and Fellows of Harvard College, Board of Trustees of the University of IllinoisInventors: Paul G. Clem, Noo-Li Jeon, Milan Mrksich, Ralph G. Nuzzo, David A. Payne, George M. Whitesides, Younan Xia
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Publication number: 20020119305Abstract: An alkanethiol of formula (1):Type: ApplicationFiled: February 28, 2001Publication date: August 29, 2002Inventors: Milan Mrksich, Christian Hodneland
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Method of forming articles including waveguides via capillary micromolding and microtransfer molding
Publication number: 20020066978Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface.Type: ApplicationFiled: October 30, 2001Publication date: June 6, 2002Inventors: Enoch Kim, Younan Xia, Milan Mrksich, Rebecca J. Jackman, Xiao-Mei Zhao, Stephen P. Smith, Mara G. Prentiss, George M. Whitesides, Christian Marzolin -
Method of forming articles including waveguides via capillary micromolding and microtransfer molding
Patent number: 6355198Abstract: Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or nonplanar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface.Type: GrantFiled: January 8, 1998Date of Patent: March 12, 2002Assignee: President and Fellows of Harvard CollegeInventors: Enoch Kim, Younan Xia, Milan Mrksich, Rebecca J. Jackman, Xiao-Mei Zhao, Stephen P. Smith, Mara G. Prentiss, George M. Whitesides, Christian Marzolin -
Patent number: 6180239Abstract: Improved method of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding.Type: GrantFiled: July 8, 1996Date of Patent: January 30, 2001Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Younan Xia, James L. Wilbur, Rebecca J. Jackman, Enoch Kim, Mara G. Prentiss, Milan Mrksich, Amit Kumar, Christopher B. Gorman, Hans Biebuyck, Karl K. Berggren
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Patent number: 5900160Abstract: Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding.Type: GrantFiled: July 9, 1996Date of Patent: May 4, 1999Assignee: President and fellows of Harvard CollegeInventors: George M. Whitesides, Younan Xia, James L. Wilbur, Rebecca J. Jackman, Enoch Kim, Mara G. Prentiss, Milan Mrksich, Amit Kumar, Christopher B. Gorman, Hans Biebuyck, Karl K. Berggren