Patents by Inventor Miles W. Carroll

Miles W. Carroll has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vector
    Patent number: 7718627
    Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.
    Type: Grant
    Filed: April 25, 2006
    Date of Patent: May 18, 2010
    Assignee: Oxford Biomedica (UK) Limited
    Inventors: Susan M. Kingsman, Christopher R. Bebbington, Fiona M. Ellard, Miles W. Carroll, Kevin A. Myers
  • Polypeptide
    Patent number: 7666669
    Abstract: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: February 23, 2010
    Assignee: Oxford Biomedica (UK) Limited
    Inventors: Miles W. Carroll, Kevin A. Myers
  • Methods for detecting the differentiation status of cells using 5T4 antigen expression
    Patent number: 7662625
    Abstract: The present invention relates to methods for detecting the differentiation status of stem cells comprising detecting the expression of 5T4 antigen in said stem cells. The present invention also relates to methods for separating populations of undifferentiated or differentiated mammalian stem cells from a mixture of differentiated and undifferentiated stem cells through detection of 5T4 expression.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: February 16, 2010
    Assignee: Cancer Research Technology Limited
    Inventors: Peter L. Stern, Miles W. Carroll, Christopher M. Ward
  • Polypeptide
    Patent number: 7615612
    Abstract: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: November 10, 2009
    Assignee: Oxford Biomedica (UK) Limited
    Inventors: Miles W. Carroll, Kevin A. Myers
  • Polypeptide
    Patent number: 7601698
    Abstract: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: October 13, 2009
    Assignee: Oxford Biomedica (UK) Limited
    Inventors: Miles W. Carroll, Kevin A. Myers
  • CASCADE
    Publication number: 20090191230
    Abstract: The invention provides the use of an enzyme and a prodrug in the manufacture of a medicament for use in inducing an anti-tumour immune response in a human patient.
    Type: Application
    Filed: July 10, 2006
    Publication date: July 30, 2009
    Applicant: Oxford Biomedica (UK) Limited
    Inventors: Richard Harrop, Miles W. Carroll, Susan M. Kingsman
  • Antibodies
    Patent number: 7514546
    Abstract: The use of an ScFv Ab (ScFv Ab) capable of recognizing a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: April 7, 2009
    Assignee: Oxford BioMedica (UK) Ltd.
    Inventors: Susan Mary Kingsman, Christopher R. Bebbington, Miles W. Carroll, Fiona M. Ellard, Kevin A. Myers
  • VECTOR SYSTEM
    Publication number: 20080175819
    Abstract: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.
    Type: Application
    Filed: August 6, 2007
    Publication date: July 24, 2008
    Applicant: Oxford BioMedica (UK) Limited
    Inventors: Alan J. Kingsman, Christopher R. Bebbington, Miles W. Carroll, Fiona M. Ellard, Susan M. Kingsman, Kevin A. Myers
  • Vector system
    Patent number: 7276488
    Abstract: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: October 2, 2007
    Assignee: Oxford Biomedica (UK) Limited
    Inventors: Alan J. Kingsman, Christopher R. Bebbington, Miles W. Carroll, Fiona M. Ellard, Susan M. Kingsman, Kevin A. Myers
  • Method of eukaryotic expression cloning of disease associated molecules
    Publication number: 20040096864
    Abstract: The present invention describes a method for identifying a target disease associated molecule (DAM) comprising: generating an expression library from DNA or RNA derived from a cell expressing the DAM; transfecting the library into a eukaryotic host cell; and screening the expression library with a screen comprising a binding partner to identify DNA clones expressing the target DAM. The library may produced by inserting the cDNA library into a virus based vector, such as a pox viral vector with a minimal viral genome.
    Type: Application
    Filed: December 16, 2003
    Publication date: May 20, 2004
    Inventors: Miles W. Carroll, Susan M. Kingsman
  • Vector system
    Publication number: 20030083290
    Abstract: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.
    Type: Application
    Filed: January 29, 2002
    Publication date: May 1, 2003
    Inventors: Alan J. Kingsman, Christopher R. Bebbington, Miles W. Carroll, Fiona M. Ellard, Susan M. Kingsman, Kevin A. Myers