Patents by Inventor Ming-Bo Wang
Ming-Bo Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220275381Abstract: The present invention relates to new double stranded RNA (dsRNA) structures and their use in modulating flowering in plants. The present invention also relates to methods of modulating the time of plant flowering.Type: ApplicationFiled: August 3, 2020Publication date: September 1, 2022Inventors: Jonathan Paul ANDERSON, Ming Bo WANG, Neil Andrew SMITH, Christopher Andrew HELLIWELL, Stephen Mark SWAIN
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Publication number: 20210269800Abstract: The present invention relates to new double stranded RNA (dsRNA) structures and their use in gene silencing.Type: ApplicationFiled: August 2, 2019Publication date: September 2, 2021Inventors: Neil Andrew SMITH, Ming Bo WANG, Daai ZHANG, Timothy James DORAN, Mark TIZARD, Annapurna Devi ALLU, Ian Kevin GREAVES, Lingling GAO, Jonathan Paul ANDERSON, Robert DE FEYTER
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Publication number: 20200263174Abstract: The present invention relates to new double stranded RNA (dsRNA) structures and their use in gene silencing.Type: ApplicationFiled: September 17, 2018Publication date: August 20, 2020Inventors: Neil Andrew SMITH, Ming-Bo WANG, Timothy James DORAN, Mark TIZARD, Annapurna Devi ALLU, Ian Kevin GREAVES, Lingling GAO, Jonathan Paul ANDERSON, Daai ZHANG, Robert DE FEYTER
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Patent number: 10190127Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.Type: GrantFiled: July 7, 2017Date of Patent: January 29, 2019Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Peter Waterhouse, Ming-Bo Wang
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Publication number: 20180179549Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.Type: ApplicationFiled: July 7, 2017Publication date: June 28, 2018Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter Waterhouse, Ming-Bo Wang
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Patent number: 9885038Abstract: Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through different processing pathways. Also provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to different nucleic acids, but which are processed into short interfering RNA molecules through different processing pathways.Type: GrantFiled: March 17, 2015Date of Patent: February 6, 2018Assignee: Commonwealth Scientific & Industrial Research OrganisationInventors: Ming-Bo Wang, Peter Waterhouse
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Patent number: 9708621Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.Type: GrantFiled: July 15, 2016Date of Patent: July 18, 2017Assignee: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Peter Michael Waterhouse, Ming-Bo Wang
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Publication number: 20170114354Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.Type: ApplicationFiled: September 8, 2016Publication date: April 27, 2017Applicant: Commonwealth Scientific & Industrial Research OrganisationInventors: Peter Michael Waterhouse, Ming Bo Wang, Michael Wayne Graham
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Publication number: 20160355833Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.Type: ApplicationFiled: July 15, 2016Publication date: December 8, 2016Inventors: Peter Michael Waterhouse, Ming-Bo Wang
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Patent number: 9441239Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.Type: GrantFiled: March 1, 2006Date of Patent: September 13, 2016Assignee: Commonwealth Scientific & Industrial Research OrganisationInventors: Peter Michael Waterhouse, Ming-Bo Wang, Michael Wayne Graham
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Patent number: 9399777Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.Type: GrantFiled: April 22, 2011Date of Patent: July 26, 2016Assignee: Commonwealth Scientific & Industrial Research OrganisationInventors: Peter Michael Waterhouse, Ming-Bo Wang
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Publication number: 20150259682Abstract: Provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to the same nucleic acid, but which are processed into short interfering RNA molecules through different processing pathways. Also provided are methods and means to obtain improved gene silencing of target nucleic acids whereby at least two inhibitory RNA molecules are provided which are targeted to different nucleic acids, but which are processed into short interfering RNA molecules through different processing pathways.Type: ApplicationFiled: March 17, 2015Publication date: September 17, 2015Inventors: Ming-Bo WANG, Peter WATERHOUSE
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Patent number: 8716557Abstract: Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant RNAi construct that provides for the inhibition of expression of ?1,3-fucosyltransferase (FucT) and ?1,2-xylosyltransferase (XylT) in a plant. Use of these RNAi constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a “humanized” N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the G0 glycoform, are also provided.Type: GrantFiled: January 17, 2007Date of Patent: May 6, 2014Assignee: Synthon Biopharmaceuticals B.V.Inventors: Lynn F. Dickey, Kevin M. Cox, Charles G. Peele, Ming-Bo Wang
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Patent number: 8598332Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.Type: GrantFiled: April 7, 1999Date of Patent: December 3, 2013Assignee: Bayer CropScience N.V.Inventors: Peter Michael Waterhouse, Ming-Bo Wang, Michael Wayne Graham, Neil A. Smith
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Patent number: 8334374Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.Type: GrantFiled: May 17, 2012Date of Patent: December 18, 2012Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter Michael Waterhouse, Ming-Bo Wang
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Publication number: 20120276086Abstract: The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the grown of CD30+ cells, such as tumor cells, are also provided.Type: ApplicationFiled: April 18, 2012Publication date: November 1, 2012Applicants: MEDAREX, INC., BIOLEX THERAPEUTICS, INC.Inventors: Amelia Nancy BLACK, David B. PASSMORE, Mohan SRINIVASAN, Lynn F. DICKEY, Kevin M. COX, Charles G. PEELE, Ming-Bo WANG
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Publication number: 20120270315Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specifc RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.Type: ApplicationFiled: May 17, 2012Publication date: October 25, 2012Inventors: Peter Michael Waterhouse, Ming-Bo Wang
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Publication number: 20120210469Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells, particularly in plant cells, by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated target-specific RNA is provided by transcription of a chimeric gene comprising a promoter, a DNA region encoding the target-specific RNA, a self-splicing ribozyme and a DNA region involved in 3? end formation and polyadenylation.Type: ApplicationFiled: April 22, 2011Publication date: August 16, 2012Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter Michael WATERHOUSE, Ming-Bo Wang
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Patent number: 8183217Abstract: Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eukaryotic cells by providing aberrant, preferably unpolyadenylated, target-specific RNA to the nucleus of the host cell. Preferably, the unpolyadenylated, target-specific RNA is provided by transcription of a chimeric gene comprising a promoter and a DNA region encoding the target-specific RNA.Type: GrantFiled: July 13, 2005Date of Patent: May 22, 2012Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Peter Michael Waterhouse, Ming-Bo Wang
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Publication number: 20110231955Abstract: Methods and means are provided to increase the efficiency of gene silencing when using dsRNA sequences which have a stem length shorter than about 200 base pairs by providing chimeric genes encoding such dsRNA sequences with a promoter recognized by DNA dependent RNA polymerase III comprising all cis-acting promoter elements which interact with DNA dependent RNA polymerase III.Type: ApplicationFiled: January 3, 2011Publication date: September 22, 2011Applicant: Commonwealth Scientific and Industrial Research OrganisationInventors: Ming Bo WANG, Christopher A. HELLIWELL, Peter M. WATERHOUSE