Abstract: A method of forming a gas spacer in a semiconductor device and a semiconductor device including the same are disclosed. In accordance with an embodiment, a method includes forming a gate stack over a substrate; forming a first gate spacer on sidewalls of the gate stack; forming a second gate spacer on sidewalls of the first gate spacer; removing the second gate spacer using an etching process to form a first opening, the etching process being performed at a temperature less than 0° C., the etching process using an etching solution including hydrogen fluoride; and depositing a dielectric layer over the first gate spacer and the gate stack, the dielectric layer sealing a gas spacer in the first opening.

Abstract: An intelligent monitoring system for waste disposal and the method thereof are provided, which include a plurality of operational devices and stages. First, a transportation stage is performed to loading a transport vehicle with a waste so as to transport the waste to a disposal station for further treatment. A camera and a sensor for detecting abnormal conditions are installed any one of the operational devices or installed in the operational path of any one of the operational devices. The camera records the videos of the operational stages, captures the images from the videos and recognizes the images in order to determine whether the abnormal conditions occur in any one of the operational stages. Alternatively, the camera is triggered to capture the images and recognize the images after the abnormal conditions are detected by the sensor in order to determine whether the abnormal conditions actually occur.

Abstract: An electronic device includes a first substrate structure, multiple electronic elements and a second substrate structure. The first substrate structure includes a first substrate. The electronic elements are disposed on the first substrate. The second substrate structure is coupled to the first substrate structure. The second substrate structure includes a second substrate, a protection circuit, a driving circuit and a bonding pad. The protection circuit is disposed on the second substrate. The driving circuit is disposed on the second substrate and configured to drive at least a part of the electronic elements. The bonding pad is disposed on the second substrate. The protection circuit is respectively coupled to the bonding pad and the driving circuit. The electronic device may reduce the damage caused by electrostatic discharge or reduce the impact of the bonding process of the bonding pad on signal conduction.

Abstract: An electrical connection structure is provided. The electrical connection structure includes a through hole, a first pad, a second pad and a conductive bridge. The through hole has a first end and a second end. The first pad at least partially surrounds the first end of the through hole and is electrically connected to a first circuit. The second pad is located at the second end of the through hole and is electrically connected to a second circuit. The conductive bridge is connected to the first pad and second pad through the through hole, thereby making the first and second circuits electrically connected to each other.

Abstract: A probiotic composition for improving an effect of a chemotherapeutic drug of Gemcitabine on inhibiting pancreatic cancer is disclosed in the present disclosure. The probiotic composition comprises an effective amount of Lactobacillus paracasei GMNL-133, an effective amount of Lactobacillus reuteri GMNL-89, and a pharmaceutically acceptable carrier, wherein the Lactobacillus paracasei GMNL-133 was deposited in the China Center for Type Culture Collection on Sep. 26, 2011 under an accession number CCTCC NO. M 2011331, and the Lactobacillus reuteri GMNL-89 was deposited in the China Center for Type Culture Collection on Nov. 19, 2007 under an accession number CCTCC NO. M 207154. A method for improving the effect of the chemotherapeutic drug of Gemcitabine on inhibiting pancreatic cancer is further disclosed in the present disclosure.

Abstract: Methods of cutting gate structures and fins, and structures formed thereby, are described. In an embodiment, a substrate includes first and second fins and an isolation region. The first and second fins extend longitudinally parallel, with the isolation region disposed therebetween. A gate structure includes a conformal gate dielectric over the first fin and a gate electrode over the conformal gate dielectric. A first insulating fill structure abuts the gate structure and extends vertically from a level of an upper surface of the gate structure to at least a surface of the isolation region. No portion of the conformal gate dielectric extends vertically between the first insulating fill structure and the gate electrode. A second insulating fill structure abuts the first insulating fill structure and an end sidewall of the second fin. The first insulating fill structure is disposed laterally between the gate structure and the second insulating fill structure.

Abstract: A thiolation method for modifying nanodiamonds includes steps as follows. A carboxylation step is provided, wherein the nanodiamonds are reacted with an oxidant for generating carboxyl groups on surfaces of the nanodiamonds so as to form carboxylated nanodiamonds. A hydroxylation step is provided, wherein the carboxyl groups of the carboxylated nanodiamonds are transformed into hydroxyl groups so as to transform the carboxylated nanodiamonds into hydroxylated nanodiamonds. A thiolation step is provided. In the thiolation step, the hydroxylated nanodiamonds, a sulfur source and a first acidic substance are mixed and then stirred so as to form a first mixture, the first mixture is added portion-wisely into an alkaline solution so as to form a second mixture, and the second mixture is acidified so as to form an acidified solution having a pH value ranging from 2 to 3, thus the hydroxylated nanodiamonds are transformed into thiolated nanodiamonds.

Abstract: A thiolation method for modifying carbon nanotubes includes steps as follows. A carboxylation step is provided, wherein the carbon nanotubes are reacted with an oxidant for generating carboxyl groups on surfaces of the carbon nanotubes so as to form carboxylated carbon nanotubes. A hydroxylation step is provided, wherein the carboxyl groups are transformed into hydroxyl groups so as to transform the carboxylated carbon nanotubes into hydroxylated carbon nanotubes. A thiolation step is provided, wherein the hydroxylated carbon nanotubes, a sulfur source and a first acidic substance are mixed and then stirred so as to form a first mixture, the first mixture is added portion-wisely into an alkaline solution so as to form a second mixture, and the second mixture is acidified so as to form an acidified solution having a pH value ranging from 2 to 3, thus the hydroxylated carbon nanotubes are transformed into thiolated carbon nanotubes.

Abstract: A thiolation method for modifying nanodiamonds includes steps as follows. A carboxylation step is provided, wherein the nanodiamonds are reacted with an oxidant for generating carboxyl groups on surfaces of the nanodiamonds so as to form carboxylated nanodiamonds. A hydroxylation step is provided, wherein the carboxyl groups of the carboxylated nanodiamonds are transformed into hydroxyl groups so as to transform the carboxylated nanodiamonds into hydroxylated nanodiamonds. A thiolation step is provided. In the thiolation step, the hydroxylated nanodiamonds, a sulfur source and a first acidic substance are mixed and then stirred so as to form a first mixture, the first mixture is added portion-wisely into an alkaline solution so as to form a second mixture, and the second mixture is acidified so as to form an acidified solution having a pH value ranging from 2 to 3, thus the hydroxylated nanodiamonds are transformed into thiolated nanodiamonds.

Abstract: A thiolation method for modifying carbon nanotubes includes steps as follows. A carboxylation step is provided, wherein the carbon nanotubes are reacted with an oxidant for generating carboxyl groups on surfaces of the carbon nanotubes so as to form carboxylated carbon nanotubes. A hydroxylation step is provided, wherein the carboxyl groups are transformed into hydroxyl groups so as to transform the carboxylated carbon nanotubes into hydroxylated carbon nanotubes. A thiolation step is provided, wherein the hydroxylated carbon nanotubes, a sulfur source and a first acidic substance are mixed and then stirred so as to form a first mixture, the first mixture is added portion-wisely into an alkaline solution so as to form a second mixture, and the second mixture is acidified so as to form an acidified solution having a pH value ranging from 2 to 3, thus the hydroxylated carbon nanotubes are transformed into thiolated carbon nanotubes.

Abstract: The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof.

Abstract: Novel compounds which are derivatives of tetra-O-methyl nordihydroguaiaretic acid (NDGA), as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof are provided. These NDGA derivatives have a nitroimidazole moiety and these derivatives show preferential toxicity to hypoxic cells as hypoxic cytotoxins. Their cytotoxicity toward hypoxic cells is a result of abstraction of hydrogen from target molecules by free radicals formed in the reduction of the nitro group. This makes the disclosed compounds an effective anti cancer drug because hypoxic cells are generally considered to be more resistant to anti cancer drugs than normal cells. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including hepatocellular carcinoma, breast cancer and prostate cancer, are also provided.

Abstract: The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof.

Abstract: Novel compounds which are derivatives of tetra-O-methyl nordihydroguaiaretic acid (NDGA), as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof are provided. These NDGA derivatives have a nitroimidazole moiety and these derivatives show preferential toxicity to hypoxic cells as hypoxic cytotoxins. Their cytotoxicity toward hypoxic cells is a result of abstraction of hydrogen from target molecules by free radicals formed in the reduction of the nitro group. This makes the disclosed compounds an effective anti cancer drug because hypoxic cells are generally considered to be more resistant to anti cancer drugs than normal cells. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including hepatocellular carcinoma, breast cancer and prostate cancer, are also provided.

Abstract: Reaction of nordihydroguaiaretic acid with various alkyl chlorides, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1?-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respectively, in 67-83% yields (Scheme 1 and Scheme 2). Among these derivatives, the nitrogen-containing compounds were converted to the corresponding hydrochloride salts. Having good solubility, these NDGA derivatives were found to be stable in aqueous solution. These new compounds exerted potent activities against HIV Tat-regulated transactivation in cos-7 cells. The most active transcription inhibitor compound of this series 5b (P4N, Tetrapiperidino NDGA, meso-2,3-dimethyl-1,4-bis(3,4-[2-(piperidino)ethoxypehnyl])butane tetrakishydrochloride salt) has an IC50 of 0.88 ?M.

Abstract: Reaction of nordihydroguaiaretic acid with various alkyl chlorides, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1?-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respectively, in 67-83% yields (Scheme 1 and Scheme 2). Among these derivatives, the nitrogen-containing compounds were converted to the corresponding hydrochloride salts. Having good solubility, these NDGA derivatives were found to be stable in aqueous solution. These new compounds exerted potent activities against HIV Tat-regulated transactivation in cos-7 cells. The most active transcription inhibitor compound of this series 5b (P4N, Tetrapiperidino NDGA, meso-2,3-dimethyl-1,4-bis(3,4-[2-(piperidino)ethoxyphenyl])butane tetrakishydrochloride salt) has an IC50 of 0.88 ?M.

Abstract: Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections.