Abstract: A light-emitting diode and a manufacturing method thereof are provided. The manufacturing method includes following steps. First, an LED wafer is provided. The LED wafer includes a substrate and a light-emitting semiconductor stacking structure positioned on the surface of the substrate. The light-emitting semiconductor stacking structure includes a first type semiconductor layer, an active layer, and a second type semiconductor layer from a side of the substrate. Second, dicing lanes are defined on the upper surface of the LED wafer. Third, dicing is performed along the dicing lanes of the substrate using a laser. The laser is focused on the lower surface of the substrate to form a surface hole and focused inside the substrate to form an internal hole. The diameter of the surface hole is greater than the diameter of the internal hole. Fourth, the LED wafer is separated into LED chips along the dicing lanes.

Abstract: Disclosed are a computer-implemented method, a system, and a computer program product for system-level tunable parameter identification. Performance characteristic data for an application to be tuned can be obtained by one or more processing units. At least one system-level tunable parameter for the application to be tuned can be identified by one or more processing units based on the obtained performance characteristic data for the application to be tuned and a pattern between training performance characteristic data and a set of training system-level parameter-related correlation coefficients. The set of training system-level parameter-related correlation coefficients can be respective correlation coefficients of system-level tunable parameters with respect to at least one performance metric.

Abstract: This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment.

Abstract: Aspects of the present disclosure relate to converting between structured and tabular data formats. Data can be received in a tabular format. An array can be built for each of a plurality of objects within the data in the tabular format, each object corresponding to at least one identified header of the identified headers. A data row can be parsed using at least one of the built arrays and data within the data row can be added to the structured format in a specific location based characteristics indicated in the at least one array. Data can also be converted from the structured format into the tabular format using the built arrays.

Abstract: A computer-implemented method, system, and computer program product are provided for optimization with domain knowledge requirements. The method includes receiving, by a processor device, domain knowledge requirements for a target system. The method also includes defining, by a domain knowledge manager, a status of the domain knowledge employing a factor responsive to the domain knowledge. The method additionally includes computing, by an effective metric generator, effective performance metrics responsive to the status of the domain knowledge requirements and real performance metrics. The method further includes generating, by an optimization engine, a target system configuration responsive to the effective performance metrics and the real performance metrics. The method also includes improving the target system by changing a state of a function in the target system responsive to the target system configuration.

Abstract: A light source module including a substrate, a first copper trace, a second copper trace, a third copper trace, a first light emitting unit, and a second light emitting unit is provided. The second light emitting unit is electrically connected to the first light emitting unit. The first light emitting unit and the second light emitting unit are disposed in parallel along a first direction and respectively have a positive electrode and a negative electrode opposite to each other in a second direction, which is perpendicular to the first direction. The negative electrode of the first light emitting unit is connected to the first copper trace, the positive electrode of the second light emitting unit is connected to the second copper trace, and the positive electrode of the first light emitting unit and the negative electrode of the second light emitting unit are connected to the third copper trace.

Abstract: A light source module including a ceramic substrate, copper traces, light emitting units, and heat conductive columns is provided. The first heat conductive column and the second heat conductive column correspond to the first light emitting unit and the second light emitting unit respectively. The negative electrode of the first light emitting unit is connected to the first copper trace, the positive electrode of the second light emitting unit is connected to the second copper trace, and the positive electrode of the first light emitting unit and the negative electrode of the second light emitting unit are connected to the third copper trace. An end of the first heat conductive column is connected to the positive electrode of the first light emitting unit, and an end of the second heat conductive column is connected to the negative electrode of the second light emitting unit.

Abstract: A light source module including a ceramic substrate, copper traces, light emitting units, and heat conductive columns is provided. The first heat conductive column and the second heat conductive column correspond to the first light emitting unit and the second light emitting unit respectively. The negative electrode of the first light emitting unit is connected to the first copper trace, the positive electrode of the second light emitting unit is connected to the second copper trace, and the positive electrode of the first light emitting unit and the negative electrode of the second light emitting unit are connected to the third copper trace. An end of the first heat conductive column is connected to the positive electrode of the first light emitting unit, and an end of the second heat conductive column is connected to the negative electrode of the second light emitting unit.

Abstract: This invention relates to methods and compositions for treating central nervous system (CNS) disorders with cognitive impairment. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating central nervous system (CNS) disorders with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), amnestic MCI (aMCI), Age-Associated Memory Impairment (AAMI), Age Related Cognitive Decline (ARCD), dementia, Alzheimer's Disease(AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrphic lateral sclerosis and cancer-therapy-related cognitive impairment.

Abstract: A light source module is provided. The light source module includes a metal substrate, a ceramic substrate, a heat conducting element, and a light emitting unit. The metal substrate has a surface. The ceramic substrate is disposed on the surface of the metal substrate, and the ceramic substrate has an upper surface. The heat conducting element partially covers the upper surface of the ceramic substrate and the surface of the metal substrate. The light emitting unit is disposed on the upper surface of the ceramic substrate. When the light emitting unit emits light, a portion of the heat generated by the light emitting unit is conducted from the ceramic substrate to the metal substrate via the heat conducting element.

Abstract: This disclosure is related to aromatic compounds of formula (I), and methods of their use in treating medical conditions associated with Heat Shock Protein-90 (HSP90), e.g., cancer. Compounds of formula (I) have the following structure: Also disclosed are pharmaceutical compositions comprising compounds of formula (I).

Abstract: Disclosed is hydroxamic acid compounds of Formula (I) set forth herein. Also disclosed are a pharmaceutical composition containing such a compound and a method of using the compound for treating a condition associated with histone deacetylase 6.

Abstract: The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an acetylcholinesterase inhibitor (AChEI) or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In particular, it relates to the use of a combination of an SV2A inhibitor and an AChEI in treating a central nervous system disorder with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrophic lateral sclerosis (ALS), and cancer-therapy-related cognitive impairment.

Abstract: This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognitive impairment or are at risk thereof, including, without limitation, subjects having or at risk for Mild Cognitive Impairment (MCI), Age-related Cognitive Decline (ARCD) or Age-Associated Memory Impairment (AAMI).

Abstract: The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.

Abstract: An artificial intelligence (AI) platform to support workflow version process control. One or more workflows corresponding to one or more workflow engines are monitored. A neural network is employed to capture a relationship associated with a detected change in the monitored workflows. The neural network is leveraged to identify and assess an impact of the detected change to one or more additional workflows. Responsive to the assessment, the impacted workflow engines are optimized. The optimization includes automatically mapping and encoding changes corresponding to the impacted workflow. The one or more workflows containing the encoded changes are then executed.

Abstract: The invention relates to the use of Indoline derivatives, and their effective dose in the prevention and/or treatment of fibrosis diseases. The compound can effectively prevent and/or treat a fibrosis disease without cytotoxicity or genotoxicity.

Abstract: Method and apparatus for reducing resource consumption in container image management. Embodiments include receiving directory information and checksum information corresponding to a plurality of files of a container image. Embodiments include determining, based on the directory information and the checksum information, whether each file of the plurality of files is present in a repository. For each respective file of the plurality of files that is determined to be present in the repository, embodiments include updating a file list for the container image to indicate a respective location in the repository of the respective file. For each given file of the plurality of files that is determined not to be present in the repository, embodiments include storing the given file at a given location in the repository and updating the file list for the container image to indicate the given location in the repository of the given file.

Abstract: Aspects of the present disclosure relate to converting between structured and tabular data formats. Data can be received in a tabular format. An array can be built for each of a plurality of objects within the data in the tabular format, each object corresponding to at least one identified header of the identified headers. A data row can be parsed using at least one of the built arrays and data within the data row can be added to the structured format in a specific location based characteristics indicated in the at least one array. Data can also be converted from the structured format into the tabular format using the built arrays.

Abstract: The present disclosure provides a computer-implemented method, computer system and computer program product for application containerization. According to the computer-implemented method, an application to be containerized can be traced. Information obtained in the tracing can be analyzed to determine one or more features of the application. An image template for the application can be created based on the one or more features. Then, a container image for the application can be built based on the image template.