Abstract: A perfusive tissue phantom is disclosed. An example tissue phantom includes a chamber with fluid inlets disposed on a first side and fluid outlets disposed on a second side spaced apart from the first side. The tissue phantom also includes a hydrogel region connected to at least one of the fluid inlets and including a permeable hydrogel with structural characteristics that simulate a type of tissue. The tissue phantom also includes a microfluidic conduit coupled to at least one of the fluid inlets. The microfluidic conduit is a flexible, semi-permeable fiber that simulates a blood vessel. The structural characteristics of the permeable hydrogel may include a selected density, porosity, rigidity and dimension that approximate a target density, porosity, rigidity and dimension of interstitial space of the type of tissue.

Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.

Abstract: Examples of the disclosure data enable interactions of a user with an object to be used to improve the classification of the object in mediated reality applications. In examples of the disclosure LiDAR data is obtained from a mediated reality device. The mediated reality device is used by a user and the LiDAR data includes data points representing at least part of an object. Position data relating to a position of the user's hand relative to the object is obtained and interaction data indicating how the user's hand is interacting with the object is also obtained. At least some of the interaction data is obtained from an electromyography device coupled to the user. The position data is used to map the interaction data to the LiDAR data to enable the interaction data to be used to classify the object.

Abstract: An apparatus comprising: multiple exterior electrodes; and means for controlling input electrical signals provided to a sub-set of the multiple exterior electrodes to control a three-dimensional location in a body of a subject where the input electrical signals combine to selectively stimulate at least first sensational receptors of the body.

Abstract: Examples of the disclosure relate to systems and apparatus that enable a pain profile to be generated. The apparatus comprises means for enabling stimulation of a biological sample using a plurality of electrical stimulating signals. The plurality of electrical stimulating signals comprise different values for one or more parameters and respective electrical stimulating signals are configured to cause a respective change in the biological sample wherein the respective change is optically detectable. The apparatus is also configured to enable measuring of the optically detectable changes caused by the electrical stimulating signals. The optically detectable changes can be measured by using one or more optical devices to detect the optically detectable changes. The measurements obtained by the one or more optical devices and the corresponding values for the one or more parameters of the electrical stimulating signals can be used to generate a pain profile for the biological sample.

Abstract: Examples of the disclosure relate to apparatus, methods and computer programs for identifying characteristics of biological samples. The apparatus can comprise means for obtaining a plurality of multi-dimensional and multi-layered datasets from a biological sample and dividing the plurality of multi-dimensional and multi-layered datasets into a plurality of sections wherein each section comprises at least one feature. The means are also for filtering, for at least a subset of the sections, the plurality of multi-dimensional and multi-layered datasets to select features of interest, comparing the selected features of interest to a plurality of reference features and making one or more associations between two or more selected features of interest to identify one or more characteristics of the biological sample.

Abstract: Examples of the disclosure relate to an apparatus for providing electrical input signals to a biological sample so as to provide a plurality of corresponding electrical output signals. The apparatus is configured so that the electrical output electrical signals have passed through the biological sample. This means that the electrical output signals comprise of information about the properties of the biological sample. In examples of the disclosure, the electrical input signal can be controlled so that the electrical output signals comprise of general features and sub-features that enable characteristics of the biological sample to be identified. The use of these general features and sub-features can enable the characteristics to be identified without creating a reconstruction of the biological sample.

Abstract: Examples of the disclosure relate to an apparatus for analysing fluid samples. The apparatus is sized and shaped so that it can fit into an input port of an electronic device. The input port could be an existing port of the electronic device such as an input port for a memory card or a charger. The electronic device can be configured with a heat transfer means so that, when the apparatus is inserted into the electronic device, heat from the electronic device can be used to control the temperature of a fluid sample within the apparatus. This can enable the reaction conditions within the apparatus to be controlled.

Abstract: A perfusive tissue phantom is disclosed. An example tissue phantom includes a chamber with fluid inlets disposed on a first side and fluid outlets disposed on a second side spaced apart from the first side. The tissue phantom also includes a hydrogel region connected to at least one of the fluid inlets and including a permeable hydrogel with structural characteristics that simulate a type of tissue. The tissue phantom also includes a microfluidic conduit coupled to at least one of the fluid inlets. The microfluidic conduit is a flexible, semi-permeable fiber that simulates a blood vessel. The structural characteristics of the permeable hydrogel may include a selected density, porosity, rigidity and dimension that approximate a target density, porosity, rigidity and dimension of interstitial space of the type of tissue.

Abstract: Examples of the disclosure relate to apparatus, methods and computer programs for analysis of biological samples. The apparatus comprising means for: obtaining a model representing electrical properties of a biological sample where the biological sample comprises a plurality of different cell types and the model comprises a plurality of different sub-circuits where the sub-circuits represent individual structures within cells of the biological sample such that the sub-circuits have electrical properties corresponding to the electrical properties of the cells; using the obtained model to determine expected output signals obtained in response to an electrical signal provided between two or more electrodes positioned on the biological sample; and using the expected output signals to adjust one or more settings of the electrodes.

Abstract: Examples of the disclosure relate to systems and methods for analysing cellular samples. The systems can comprise apparatus comprising means for providing a stimulating signal to a cellular sample wherein the stimulating signal stimulates the cellular sample so as to modify one or more electrical properties of the cellular sample and providing a plurality of electrical input signals having a plurality of different frequencies to the cellular sample. The apparatus can also comprise means for receiving electrical output signals from the cellular sample where the electrical output signals correspond to the electrical input signals and the values of the electrical output signals are determined by the modified electrical properties of the cellular sample; and enabling spectroscopic analysis of the electrical output signals to identify a type of cell in the cellular sample from the modified electrical properties.

Abstract: The application relates to an apparatus which comprises at least one portion of artificial skin (103) and a plurality of sensors (105) dispersed within the at least one portion of artificial skin (103). The plurality of sensors (105) have at least one physical property which is configured to be modified when the plurality of sensors (105) are exposed to a parameter such that the modification of the physical property can be detected by an external detector (211). The application also relates to detection systems comprising such apparatus.

Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.

Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.

Abstract: An electrode apparatus comprising: a substrate, the substrate comprising: a first microfluidic channel; a second microfluidic channel; and at least one conduit extending between the first microfluidic channel and the second microfluidic channel; wherein the first microfluidic channel and the at least one conduit comprise electrically conductive material, and wherein the second microfluidic channel is exposed to the external environment and configured to absorb liquid by capillary action.

Abstract: Systems and methods for cell electroporation and molecular delivery using an intelligent, feedback controlled, microscale electroporation system for transfecting single cells.

Abstract: Smart phones capable of detecting electrical impedances of and providing electronic pulse stimuli to acupuncture points located on a human body are disclosed. An example smart phone is equipped with a hardware diagnosis module and a hardware treatment module that function based on the principle of holography of protruding parts of the human body, in addition to having regular smart phone functions. The diagnosis module may receive electrical impedance data detected from protruding parts of a human body and determine the type of illness according to the analog electrical impedance data. The treatment module may generate electronic pulse stimuli on acupoints located on the human body (such as ears, hands and feet), thereby performing electronic acupuncture treatment. The example smart phone may also detect blood pressure, heart rate, blood oxygen value and blood glucose values of the human body.

Abstract: Smart phones capable of detecting electrical impedances of and providing electronic pulse stimuli to acupuncture points located on a human body are disclosed. An example smart phone is equipped with a hardware diagnosis module and a hardware treatment module that function based on the principle of holography of protruding parts of the human body, in addition to having regular smart phone functions. The diagnosis module may receive electrical impedance data detected from protruding parts of a human body and determine the type of illness according to the analog electrical impedance data. The treatment module may generate electronic pulse stimuli on acupoints located on the human body (such as ears, hands and feet), thereby performing electronic acupuncture treatment. The example smart phone may also detect blood pressure, heart rate, blood oxygen value and blood glucose values of the human body.