Abstract: A sample processing device for a microchip, including: a sample vessel for packing a sample therein; and a reaction vessel which is continuous with the sample vessel through a channel, and to which the sample is sequentially delivered to be packed and mixed therein, in which the sample is repeatedly delivered between the sample vessel and the reaction vessel through the channel so that the sample is stirred and mixed.

Abstract: For heating or cooling a sample contained in a vessel portion through a heat transfer member held in contact with the vessel portion, there is used the vessel portion, which has a part formed of an elastic member, expands and contracts for injection and discharge of the sample, is closed other than a connecting port with a channel connected to the vessel, and expands and contracts for injection and discharge of the sample. The vessel portion expands correspondingly to the injection when the sample is injected through an inflow path serving as the channel into the vessel portion contracting in a non-contacting state with the heat transfer member. A predetermined amount of sample is injected into the vessel portion so as to expand the vessel portion, and the vessel portion comes into contact with the heat transfer member. The vessel portion is heated or cooled through the heat transfer member.

Abstract: Compressed gas is supplied from above to a specimen vessel having an open top. Transfer channels to reaction vessels are provided under a microchip and transfer channels extending from the reaction vessels are provided on the microchip. Transfer element is provided outside the microchip so as to supply the compressed gas from a member (cover) holding the microchip.

Abstract: A processing unit (2) of an active learning system calculates the degree of similarity of data for which the label value is unknown with respect to data for which the label value is known by using a first data selection section 26, and iterates at least on cycle of the active learning cycle that selects the data to be learned next based on the calculated degree of similarity, to thereby enable finding of the desired data needed for learning a rule more efficiently than a random selection. Thereafter, the processing unit (2) learns a rule based on the data for which the label value is known, and applies the learned rule to a set of unknown data for which the label value is unknown, to shift another active learning cycle that selects the data to be learned next.

Abstract: In order to carry out a learning in which newly acquired data is taken to be more important than data previously accumulated, a function is provided which sets a weight for learning data based on an acquisition order of the learning data. Furthermore, in order to carry out a learning which reflects data acquired in the last cycle and a result with respect to the data, a function is provided which feeds back a result of a learning in the last cycle to a rule and sets a weight for learning data based on a relation between a label of data and a prediction value.

Abstract: An individual identification method for identifying an individual by analyzing a DNA sample through electrophoresis, comprises: a first analysis step of analyzing an identifier-attached DNA sample which is given an identifier for an individual; a step of storing a result obtained by analyzing the identifier-attached DNA sample together with a corresponding identifier in a database; a second analysis step of analyzing a new sample which is a DNA sample subjected to individual identification with an accuracy lower than the accuracy when the identifier-attached DNA sample is analyzed, and using the result as a new sample analysis result; and a step of searching the database based on the new sample analysis result.

Abstract: A proteome analysis method includes using a tandem type mass spectrometer to calculate bond dissociation energy by using molecular simulation, using the bond dissociation energy to obtain prediction information including a cleavage pattern of a peptide and/or peak positions in a mass spectrum and/or the intensity ratio of the mass spectrum, and identifying a protein by using the prediction information and experiment information.

Abstract: It is intended to provide a method for immobilizing, onto a column carrier, a compound having a sulfo group or a compound to which a sulfo group can be added. The method comprises immobilizing the compound onto the column carrier using a linker comprising: a sulfo group-binding group capable of forming a bond with the sulfo group in the compound; and a carrier-binding group capable of forming a bond with a group present on the surface of the column carrier.

Abstract: A liquid sample (104) introduced in a main flow passage (101) is held in a dam portion (105), and a trigger liquid (106) is filled in a trigger flow passage (102). In this state, the trigger liquid (106) is further introduced at desired timing into the trigger flow passage (102) so that the front end portion of the level of the trigger liquid (106) is advanced and the front end portion is brought to be into contact with the dam portion (105). This causes the liquid sample (104) to move to the right (downstream side) in the figure, resulting in the liquid sample (104) flowing out to the downstream side of the main flow passage (101). This means that the trigger liquid (106) provides priming to realize a liquid switch.

Abstract: A learning data memory unit stores a set of learning data that are composed of a plurality of descriptors and a plurality of labels. When positive cases, in which the values of desired labels are desired values, are few in number or nonexistent in the learning data memory unit, a control unit rewrites the values of desired labels to values of other similar labels to generate provisional positive cases. An active learning unit uses the provisional positive cases and negative cases to learn rules, applies these learned rules to a set of candidate data that are stored in a candidate data memory unit in which desired labels are unknown to predict the resemblance of each item of candidate data to positive cases, and based on these prediction results, selects and supplies data that are to be learned next from an input/output device.

Abstract: A liquid sample (104) introduced in a main flow passage (101) is held in a dam portion (105), and a trigger liquid (106) is filled in a trigger flow passage (102). In this state, the trigger liquid (106) is further introduced at desired timing into the trigger flow passage (102) so that the front end portion of the level of the trigger liquid (106) is advanced and the front end portion is brought to be into contact with the dam portion (105). This causes the liquid sample (104) to move to the right (downstream side) in the figure, resulting in the liquid sample (104) flowing out to the downstream side of the main flow passage (101). This means that the trigger liquid (106) provides priming to realize a liquid switch.

Abstract: A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.

Abstract: Individual components are separated with a high concentration and accurately, from a sample containing components-to-be-separated. The separation apparatus includes a channel through which a sample containing components-to-be-separated moves; and gateway portions partitioning the separation channel into a plurality of compartments. The separation apparatus further includes an external force imposing unit, which imposes external force to the components-to-be-separated so as to allow them to move through the channel. The external force imposing unit is configured so as to alternately repeatedly execute a first external force imposing pattern by which the external force is imposed in the forward direction of the channel, and a second external force imposing pattern by which the external force is imposed in the direction opposite to the forward direction along the channel. This makes it possible to fractionate the components-to-be-separated into any of the compartments.

Abstract: A sample reservoir (205) in which a sample (213) is introduced is sealed by a septum (207). On piercing the septum (207) by an injection needle, the sample reservoir (205) is communicated with the outer atmosphere, and then the sample (213) is delivered from the channel 203 to the water absorbing portion (209).

Abstract: A channel (103) is formed in a substrate (101) and a drying area (107) comprising a plurality of pillars (105) is formed in one end of the channel (103). A cover (109) is formed over the channel (103), except the area above the drying area (107). When a sample is introduced into the channel (103), it is guided to the drying area (107) by capillary phenomenon. The drying area (107) is heated by a heater (111) to evaporate the solvent for concentrating and drying the solute.

Abstract: A channel (103) is formed in a substrate (101), and a portion of the channel (103) is provided with a separating portion (107). A number of pillars are formed in the separating portion (107), and an adsorptive substance layer having an adsorptive substance, which exhibits a specific interaction for a specific substance, immobilized on the surface thereof, is formed. Once a sample is introduced into the channel (103), the specific substance is adsorbed on the adsorptive substance layer to be separated from other components. After washing the inside of the channel (103) with a buffer solution, the specific substance is desorbed from the adsorptive substance layer by flowing a eluting solution through the channel (103) and the specific substance is recovered.

Abstract: An input receiving unit receives a query to a database from a user, creates a user query for searching information in accordance with the query of the user. A query generating unit generates a database query for actually searching in accordance with the user query or a re-search query for re-searching information. A searching unit executes a search of information in accordance with the database query. A condition setting unit has an analyzing condition and an output condition. An analyzing unit analyzes an information searching result in accordance with the analyzing condition supplied from the condition setting unit. An output control unit outputs an information analyzing result as output information in accordance with the output condition supplied from the condition setting unit, creates the re-search query by using the information analyzing result, and supplies the re-search query to the query generating unit.

Abstract: The method of displaying sequences of the present invention adds visual characteristics in accordance with the mutations and/or similarities in a plurality of similar nucleotide sequences or amino acid sequences. These visual characteristics are added to regions of mutation and/or regions of similarity, and further, are added in accordance with the degree of mutation and/or similarity and in accordance with the frequency of mutation in the regions of mutation. In addition, nucleotide sequences are converted to amino acid sequences, and the visual characteristics are added based on amino acid information that includes the names or properties of amino acids that correspond to codons of the regions of mutation. Links are provided to information that relates to a plurality of similar nucleotide sequences or amino acid sequences. The homology search method of the present invention uses this sequence display method to display search results.

Abstract: A proteome analysis method and a proteome analysis system, which identifies proteins by using a mass spectrometer, in particular, which has the high accuracy and the high throughput, by using predicted results of bond cleavage parts by a molecular simulation method such as an MO method, are provided. Further, at the method and the system, even when the number of samples for identification is small, the number of times of its experiment can be decreased, and peak values buried under noise in a mass spectrum are added. And at the system, even when a new protein, which has not been registered in a protein sequence database, can be identified.

Abstract: In a neural network assembly for use in pattern recognition, a memory region memorizes reference patterns along with their categories. A pattern associator neural network is connected to the memory region and is trained in accordance with a back-propagation training algorithm in a training phase of operation to correctly recognize the reference patterns according to the categories. An adaptive input region is connected to the neural network, supplied with roughly segmented patterns as input patterns, and trained in a recognition phase of operation following the training phase. and correctly processes the input patterns into processed patterns which the neural network can correctly recognize according to the categories. Preferably, the assembly is operable in the training phase as comprising the memory region, the neural network, and a controlling part which is connected to the memory region and the neural network to train the neural network.