Patents by Inventor Minoru Fujimoto
Minoru Fujimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11527392Abstract: A precursor ion selection processing unit (22) sequentially selects precursor ions having different mass-to-charge ratios, and causes an MS/MS spectrum data acquisition processing unit (23) to acquire MS/MS spectrum data corresponding to each precursor ion. The precursor ion selection processing unit (22) sequentially selects the precursor ion having a mass-to-charge ratio which is not included in a predetermined range with respect to a mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired.Type: GrantFiled: May 29, 2018Date of Patent: December 13, 2022Assignee: SHIMADZU CORPORATIONInventors: Minoru Fujimoto, Hideki Yamamoto
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Publication number: 20220356265Abstract: The purpose of the present invention is to produce a chimeric antigen receptor (CAR) specific to glypican-1 (GPC-1) and to treat squamous cell carcinoma with genetically modified cells capable of expressing the CAR. The present invention provides: a chimeric antigen receptor for use in the treatment and/or prevention of squamous cell carcinoma, said chimeric antigen receptor comprising an extracellular domain capable of binding to GPC-1, a transmembrane domain and one or multiple intracellular domains, wherein at least one of the intracellular domains is an intracellular domain containing a primary cytosolic signaling sequence or an intracellular domain containing both a primary cytosolic signaling sequence and a secondary cytosolic signaling sequence; a genetically modified cell capable of expressing the chimeric antigen receptor; and a cell preparation containing the cell.Type: ApplicationFiled: June 22, 2022Publication date: November 10, 2022Applicants: Keio University, Iwate Medical UniversityInventors: Tomonori YAGUCHI, Kenji MORII, Yutaka KAWAKAMI, Daiki KATO, Tetsuji NAKA, Satoshi SERADA, Minoru FUJIMOTO
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Patent number: 11370845Abstract: The purpose of the present invention is to produce a chimeric antigen receptor (CAR) specific to glypican-1 (GPC-1) and to treat squamous cell carcinoma with genetically modified cells capable of expressing the CAR. The present invention provides: a chimeric antigen receptor for use in the treatment and/or prevention of squamous cell carcinoma, said chimeric antigen receptor comprising an extracellular domain capable of binding to GPC-1, a transmembrane domain and one or multiple intracellular domains, wherein at least one of the intracellular domains is an intracellular domain containing a primary cytosolic signaling sequence or an intracellular domain containing both a primary cytosolic signaling sequence and a secondary cytosolic signaling sequence; a genetically modified cell capable of expressing the chimeric antigen receptor; and a cell preparation containing the cell.Type: GrantFiled: June 24, 2016Date of Patent: June 28, 2022Assignees: Keio University, NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITYInventors: Tomonori Yaguchi, Kenji Morii, Yutaka Kawakami, Daiki Kato, Tetsuji Naka, Satoshi Serada, Minoru Fujimoto
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Publication number: 20210340275Abstract: The present invention relates to an esophageal cancer marker and application thereof. The present invention relates to: a marker that includes Glypican-1 or an expression product thereof, or a fragment or derivative thereof, and serves to identify esophageal cancer; a detection agent that includes a substance that binds to Glypican-1 or an expression product thereof; and a composition that includes a Glypican-1 inhibitor and serves to prevent or treat esophageal cancer. Herein, Glypican-1 can be SEQ ID NO: 1 (nucleic acid sequence) or SEQ ID NO: 2 (amino acid sequence), or an equivalent thereof.Type: ApplicationFiled: June 30, 2021Publication date: November 4, 2021Inventors: Tetsuji Naka, Satoshi Serada, Minoru Fujimoto, Masayoshi Toyoura, Yuji Shoya
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Publication number: 20210305034Abstract: A precursor ion selection processing unit (22) sequentially selects precursor ions having different mass-to-charge ratios, and causes an MS/MS spectrum data acquisition processing unit (23) to acquire MS/MS spectrum data corresponding to each precursor ion. The precursor ion selection processing unit (22) sequentially selects the precursor ion having a mass-to-charge ratio which is not included in a predetermined range with respect to a mass-to-charge ratio of the precursor ion for which the MS/MS spectrum data has already been acquired.Type: ApplicationFiled: May 29, 2018Publication date: September 30, 2021Applicant: Shimadzu CorporationInventors: Minoru FUJIMOTO, Hideki YAMAMOTO
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Patent number: 10890562Abstract: Under the control of an analysis control unit (5), a mass spectrometer unit (2) performs a product-ion scan measurement for a target component in a target sample within a time range where the component is introduced. It also performs a scan measurement over an m/z range including the m/z of an ion originating from a standard component within the same segment of time. A mass correction information calculator (42) calculates mass correction information from measured and theoretical values of the m/z of the ion originating from the standard component observed on an MS spectrum obtained by the scan measurement. Using the mass correction information, a mass corrector (43) corrects the m/z of each ion peak originating from the target component observed on an MS/MS spectrum obtained by the product-ion scan measurement performed within the same cycle as the scan measurement concerned.Type: GrantFiled: October 7, 2015Date of Patent: January 12, 2021Assignee: SHIMADZU CORPORATIONInventors: Hideki Yamamoto, Tohru Shiohama, Hiroaki Kozawa, Atsushige Ikeda, Minoru Fujimoto
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Publication number: 20200308299Abstract: Provided is a novel anti-Glypican-1 antibody and a method for using the same. Provided is an anti-Glypican-1 antibody having an intracellular invasion activity which has never been observed in conventional anti-Glypican-1 antibodies. By taking advantage of the intracellular invasion activity of the antibody according to the present invention, the present invention is usable for various therapeutic purposes beyond the scope of the conventional assumption. Also provided is a composition for preventing or treating Glypican-1 positive cancer, said composition comprising a complex of a substance capable of binding to Glypican-1 (for example, an anti-Glypican-1 antibody) with a drug having a cytotoxic activity.Type: ApplicationFiled: April 27, 2018Publication date: October 1, 2020Inventors: Tetsuji Naka, Satoshi Serada, Minoru Fujimoto
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Publication number: 20190023781Abstract: According to the present disclosure there are provided compositions and methods for treating malignant tumors, including an anti-LSR (lipolysis stimulated lipoprotein receptor) antibody that comprises the presently disclosed antibody heavy and light chain complementarity determining region (CDR) sequences, or an antigen-binding fragment thereof, or a functional equivalent thereof. Further provided for treating an LSR-positive malignancy is an LSR antagonist or an LSR inhibitor such as a nucleic acid. Therapeutic administration of the anti-LSR antibody to a subject having an LSR-positive malignant tumor is also described.Type: ApplicationFiled: October 3, 2018Publication date: January 24, 2019Inventors: Tetsuji Naka, Satoshi Serada, Minoru Fujimoto, Masayoshi Toyoura, Yuji Shoya
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Patent number: 10174111Abstract: According to the present disclosure there are provided compositions and methods for treating malignant tumors, including an anti-LSR (lipolysis stimulated lipoprotein receptor) antibody that comprises the presently disclosed antibody heavy and light chain complementarity determining region (CDR) sequences, or an antigen-binding fragment thereof, or a functional equivalent thereof. Further provided for treating an LSR-positive malignancy is an LSR antagonist or an LSR inhibitor such as a nucleic acid. Therapeutic administration of the anti-LSR antibody to a subject having an LSR-positive malignant tumor is also described.Type: GrantFiled: December 25, 2014Date of Patent: January 8, 2019Assignee: National University Corporation Kochi UniversityInventors: Tetsuji Naka, Satoshi Serada, Minoru Fujimoto, Masayoshi Toyoura, Yuji Shoya
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Publication number: 20180362658Abstract: The present invention relates to an esophageal cancer marker and application thereof. The present invention relates to: a marker that includes Glypican-1 or an expression product thereof, or a fragment or derivative thereof, and serves to identify esophageal cancer; a detection agent that includes a substance that binds to Glypican-1 or an expression product thereof; and a composition that includes a Glypican-1 inhibitor and serves to prevent or treat esophageal cancer. Herein, Glypican-1 can be SEQ ID NO: 1 (nucleic acid sequence) or SEQ ID NO: 2 (amino acid sequence), or an equivalent thereof.Type: ApplicationFiled: August 14, 2018Publication date: December 20, 2018Inventors: Tetsuji Naka, Satoshi Serada, Minoru Fujimoto, Masayoshi Toyoura, Yuji Shoya
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Publication number: 20180284065Abstract: Under the control of an analysis control unit (5), a mass spectrometer unit (2) performs a product-ion scan measurement for a target component in a target sample within a time range where the component is introduced. It also performs a scan measurement over an m/z range including the m/z of an ion originating from a standard component within the same segment of time. A mass correction information calculator (42) calculates mass correction information from measured and theoretical values of the m/z of the ion originating from the standard component observed on an MS spectrum obtained by the scan measurement. Using the mass correction information, a mass corrector (43) corrects the m/z of each ion peak originating from the target component observed on an MS/MS spectrum obtained by the product-ion scan measurement performed within the same cycle as the scan measurement concerned.Type: ApplicationFiled: October 7, 2015Publication date: October 4, 2018Applicant: SHIMADZU CORPORATIONInventors: Hideki YAMAMOTO, Tohru SHIOHAMA, Hiroaki KOZAWA, Atsushige IKEDA, Minoru FUJIMOTO
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Patent number: 10077316Abstract: The present invention relates to an esophageal cancer marker and application thereof. The present invention relates to: a marker that includes Glypican-1 or an expression product thereof, or a fragment or derivative thereof, and serves to identify esophageal cancer; a detection agent that includes a substance that binds to Glypican-1 or an expression product thereof; and a composition that includes a Glypican-1 inhibitor and serves to prevent or treat esophageal cancer. Herein, Glypican-1 can be SEQ ID NO: 1 (nucleic acid sequence) or SEQ ID NO: 2 (amino acid sequence), or an equivalent thereof.Type: GrantFiled: December 25, 2014Date of Patent: September 18, 2018Assignee: National University Corporation, Kochi UniversityInventors: Tetsuji Naka, Satoshi Serada, Minoru Fujimoto, Masayoshi Toyoura, Yuji Shoya
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Publication number: 20180230230Abstract: The purpose of the present invention is to produce a chimeric antigen receptor (CAR) specific to glypican-1 (GPC-1) and to treat squamous cell carcinoma with genetically modified cells capable of expressing the CAR. The present invention provides: a chimeric antigen receptor for use in the treatment and/or prevention of squamous cell carcinoma, said chimeric antigen receptor comprising an extracellular domain capable of binding to GPC-1, a transmembrane domain and one or multiple intracellular domains, wherein at least one of the intracellular domains is an intracellular domain containing a primary cytosolic signaling sequence or an intracellular domain containing both a primary cytosolic signaling sequence and a secondary cytosolic signaling sequence; a genetically modified cell capable of expressing the chimeric antigen receptor; and a cell preparation containing the cell.Type: ApplicationFiled: June 24, 2016Publication date: August 16, 2018Inventors: Tomonori Yaguchi, Kenji Morii, Yutaka Kawakami, Daiki Kato, Tetsuji Naka, Satoshi Serada, Minoru Fujimoto
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Patent number: 9611475Abstract: Provided are a novel prophylactic and/or therapeutic drug for an inflammatory disease and a method for searching for the same. A prophylactic and/or therapeutic agent for an inflammatory disease that comprises a substance capable of inhibiting the expression or function of leucine rich alpha 2 glycoprotein (LRG). A method of screening for an anti-inflammatory substance using LRG or an LRG-expressing cell, wherein the inhibition of the expression or function of LRG is used as an index.Type: GrantFiled: April 11, 2014Date of Patent: April 4, 2017Assignee: National Institutes of Biomedical Innovation, Health and NutritionInventors: Tetsuji Naka, Minoru Fujimoto, Satoshi Serada
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Publication number: 20170066836Abstract: The present invention relates to an esophageal cancer marker and application thereof. The present invention relates to: a marker that includes Glypican-1 or an expression product thereof, or a fragment or derivative thereof, and serves to identify esophageal cancer; a detection agent that includes a substance that binds to Glypican-1 or an expression product thereof; and a composition that includes a Glypican-1 inhibitor and serves to prevent or treat esophageal cancer. Herein, Glypican-1 can be SEQ ID NO: 1 (nucleic acid sequence) or SEQ ID NO: 2 (amino acid sequence), or an equivalent thereof.Type: ApplicationFiled: December 25, 2014Publication date: March 9, 2017Inventors: Tetsuji NAKA, Satoshi SERADA, Minoru FUJIMOTO, Masayoshi TOYOURA, Yuji SHOYA
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Publication number: 20170051056Abstract: The present invention makes it possible to obtain a novel therapeutic drug for malignant tumors. Specifically, the present invention provides a therapeutic drug for malignant tumors, said drug including an anti-LSR (lipolysis stimulated lipoprotein receptor) antibody or an antigen-binding fragment thereof, or a functional equivalent thereof, or an LSR inhibitor such as a nucleic acid. Said inhibitor uses a therapeutic drug for malignant tumors, said drug including an anti-LSR antibody, or an antigen-binding fragment thereof or a functional equivalent thereof. The inhibitor may also be an LSR antagonist. The abovementioned therapeutic drug may be administered to patients in whom the onset of an LSR-positive malignant tumor is judged to have occurred.Type: ApplicationFiled: December 25, 2014Publication date: February 23, 2017Inventors: Tetsuji NAKA, Satoshi SERADA, Minoru FUJIMOTO, Masayoshi TOYOURA, Yuji SHOYA
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Patent number: 9576005Abstract: A search system includes a storage device and a search server. The storage device stores an index database storing an index encrypted with an index key and the index key encrypted with a user key and associated with the encrypted index and stores a document database storing a document encrypted with a document key and the document key encrypted with the user key and associated with the encrypted document. The search server extracts a term for search from a requested search query, decrypts the encrypted index key with a user key which belongs to a user requesting the search query, encrypts the extracted term with the decrypted index key without storing the decrypted index key in a non-transitory storage device, searches the index database with the index encrypted using the encrypted first term, and sends a search result to a terminal.Type: GrantFiled: February 24, 2016Date of Patent: February 21, 2017Assignee: Hitachi Solutions, Ltd.Inventors: Minoru Fujimoto, Yoshiki Sameshima
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Patent number: 9548193Abstract: In a scan measurement in which a mass scan is repeated across a predetermined mass range, when a voltage is returned from a termination voltage of one scan to an initiation voltage for the next scan, an undershoot or other drawbacks occur to destabilize the voltage value. Therefore, an appropriate waiting time is required. Conventionally, this waiting time has been set to be constant regardless of the analysis conditions. On the other hand, in the quadrupole mass spectrometer according to the present invention, the mass difference ?M between the scan termination mass and the scan initiation mass is computed based on the specified mass range, and a different settling time is set in accordance with this mass difference. When the mass difference ?M is small and hence requires only a short voltage stabilization time, a relatively short settling time is set. This shortens the cycle period of the mass scan, which increases the temporal resolution.Type: GrantFiled: May 26, 2008Date of Patent: January 17, 2017Assignee: SHIMADZU CORPORATIONInventors: Kazuo Mukaibatake, Shigenobu Nakano, Minoru Fujimoto
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Publication number: 20160299924Abstract: A search system includes a storage device and a search server. The storage device stores an index database storing an index encrypted with an index key and the index key encrypted with a user key and associated with the encrypted index and stores a document database storing a document encrypted with a document key and the document key encrypted with the user key and associated with the encrypted document. The search server extracts a term for search from a requested search query, decrypts the encrypted index key with a user key which belongs to a user requesting the search query, encrypts the extracted term with the decrypted index key without storing the decrypted index key in a non-transitory storage device, searches the index database with the index encrypted using the encrypted first term, and sends a search result to a terminal.Type: ApplicationFiled: February 24, 2016Publication date: October 13, 2016Inventors: Minoru FUJIMOTO, Yoshiki SAMESHIMA
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Publication number: 20160083725Abstract: Provided are a novel prophylactic and/or therapeutic drug for an inflammatory disease and a method for searching for the same. A prophylactic and/or therapeutic agent for an inflammatory disease that comprises a substance capable of inhibiting the expression or function of leucine rich alpha 2 glycoprotein (LRG). A method of screening for an anti-inflammatory substance using LRG or an LRG-expressing cell, wherein the inhibition of the expression or function of LRG is used as an index.Type: ApplicationFiled: April 11, 2014Publication date: March 24, 2016Applicant: National Institute of Biomedical Innovation, Health and NutritionInventors: Tetsuji Naka, Minoru Fujimoto, Satoshi Serada