Patents by Inventor Minoru Kidokoro

Minoru Kidokoro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICRORNA-CONTROLLED RECOMBINANT VACCINIA VIRUS AND USE THEREOF
    Publication number: 20130071430
    Abstract: It is intended to provide a vaccinia virus that specifically proliferates in a cancer cell and destroys the cancer cell and to provide use of the virus in cancer treatment. The present invention provides a microRNA-controlled vaccinia virus, in which a target sequence of a microRNA less expressed in a cancer cell than in a normal cell is inserted in a 3? untranslated region of B5R gene associated with viral proliferation in a vaccinia virus, wherein the microRNA-controlled vaccinia virus specifically proliferates in the cancer cell and has an oncolytic property that destroys the cancer cell.
    Type: Application
    Filed: March 15, 2011
    Publication date: March 21, 2013
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Takafumi Nakamura, Mina Hikichi, Hideaki Tahara, Hisatoshi Shida, Minoru Kidokoro
  • Highly safe smallpox vaccine virus and vaccinia virus vector
    Patent number: 7638132
    Abstract: Objects of the present invention are to generate vaccine strains that undergo reversion (atavism) with difficulty and to provide smallpox vaccines with higher safety. The vaccine viruses are deficient in a part or the whole of the B5R gene of a vaccinia viral strain, LC16m8 or LC16mO, and produce no B5R gene products having normal functions. The vaccine viruses can be used as smallpox vaccines or vectors capable of expressing foreign genes. Hence, smallpox vaccines and vaccinia virus vectors are provided that produce no B5R gene products having normal functions due to reverse mutation.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: December 29, 2009
    Assignee: National University Corporation Hokkaido University
    Inventors: Hisatoshi Shida, Minoru Kidokoro
  • Recombinant virus and use thereof
    Publication number: 20090214587
    Abstract: The present invention provides a recombinant virus which is efficacious and highly safe in preventing the onset of SARS infection and a vaccine for SARS coronavirus containing the same. The recombinant virus of the invention can express a SARS coronavirus gene.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 27, 2009
    Applicants: Post Genome Institute Co., Ltd., The Chemo-Sero-Therapeutic Research Institute
    Inventors: Michinori Kohara, Kyosuke Mizuno, Hisatoshi Shida, Kouji Matsushima, Koichi Morita, Minoru Kidokoro, Yukie Sameshima
  • Highly Safe Smallpox Vaccine Virus and Vaccinia Virus Vector
    Publication number: 20070298054
    Abstract: Objects of the present invention are to generate vaccine strains that undergo reversion (atavism) with difficulty and to provide smallpox vaccines with higher safety. The vaccine viruses are deficient in a part or the whole of the B5R gene of a vaccinia viral strain, LC16m8 or LC16mO, and produce no B5R gene products having normal functions. The vaccine viruses can be used as smallpox vaccines or vectors capable of expressing foreign genes. Hence, smallpox vaccines and vaccinia virus vectors are provided that produce no B5R gene products having normal functions due to reverse mutation.
    Type: Application
    Filed: December 5, 2003
    Publication date: December 27, 2007
    Applicant: Hokkaido Technology Licensing Office Co., Ltd.
    Inventors: Hisatoshi Shida, Minoru Kidokoro