Abstract: A method for determining a calibration factor in Doppler flowmetry velocity measurements in the living eye includes imaging the eye with Doppler flowmetry and processing data to obtain blood velocity, volume, and flow maps using Doppler flowmetry formulas that provide velocity as a mean frequency expressed in Hz, and volume and flow in arbitrary units. A selected blood vessel is probed with Doppler OCT to measure the absolute velocity of blood at that location expressed in mm/s to determine a calibration factor used to convert the velocity measured with Doppler flowmetry expressed in Hz to velocity expressed in mm/s.

Abstract: A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at least a portion of an imaging path.

Abstract: A product critical temperature during freeze drying is determined. The product is imaged using optical coherence tomography (“OCT”). The product is freeze dried while the temperature of the product is measured. The product critical temperature is the temperature at which a product structure event occurs during freeze drying.

Abstract: A product critical temperature during freeze drying is determined. The product is imaged using optical coherence tomography (“OCT”). The product is freeze dried while the temperature of the product is measured. The product critical temperature is the temperature at which a product structure event occurs during freeze drying.

Abstract: An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first imaging beam for the SLO mode and a first detection device configured to receive a first signal associated with a first image of a retina of an eye. The second optical module for the OCT mode includes a second source adapted to provide a second imaging beam for the OCT mode and a second detection device configured to receive a second signal associated with a second image of the retina.

Abstract: A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at least a portion of an imaging path.

Abstract: An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first imaging beam for the SLO mode and a first detection device configured to receive a first signal associated with a first image of a retina of an eye. The second optical module for the OCT mode includes a second source adapted to provide a second imaging beam for the OCT mode and a second detection device configured to receive a second signal associated with a second image of the retina.

Abstract: A retinal imaging device includes an optical system configured to (i) scan a portion of the retina of the eye with a line of light, (ii) descan reflected light from the scanned portion of the retina, and (iii) provide output light in a line focus configuration. The device includes a detection device including a linear array of asymmetric pixels having at least a 2:1 ratio of length to width, a detection device with multiple adjacent linear arrays, and/or a detection device using a time delay and integration (TDI) architecture.

Abstract: A product critical temperature during freeze drying is determined. The product is imaged using optical coherence tomography (“OCT”). The product is freeze dried while the temperature of the product is measured. The product critical temperature is the temperature at which a product structure event occurs during freeze drying.

Abstract: A first optical module scans a portion of an eye with a line of light, descans reflected light from the scanned portion of the eye and confocally provides output light in a line focus configuration. A detection device detects the output light and images the portion of the eye. A second optical module detects an optical distortion and corrects the optical distortion in the line of light scanned on the portion of the eye.

Abstract: Epithelial cancer screening can include a staining tissue with a cancer targeting agent, identifying a potentially cancerous lesion using fluorescence imaging, and imaging the potentially cancerous lesion for a cancer diagnosis using optical coherence tomography.

Abstract: An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first imaging beam for the SLO mode and a first detection device configured to receive a first signal associated with a first image of a retina of an eye. The second optical module for the OCT mode includes a second source adapted to provide a second imaging beam for the OCT mode and a second detection device configured to receive a second signal associated with a second image of the retina.

Abstract: A system, arrangement, computer-accessible medium and process are provided for determining information associated with at least one portion of an anatomical structure. For example, an interference between at least one first radiation associated with a radiation directed to the anatomical structure and at least one second radiation associated with a radiation directed to a reference can be detected. Three-dimensional volumetric data can be generated for the at least one portion as a function of the interference. Further, the information can be determined which is at least one geometrical characteristic and/or at least one intensity characteristic of the portion based on the volumetric data.

Abstract: A first optical module scans a portion of an eye with a line of light, descans reflected light from the scanned portion of the eye and confocally provides output light in a line focus configuration. A detection device detects the output light and images the portion of the eye. A second optical module detects an optical distortion and corrects the optical distortion in the line of light scanned on the portion of the eye.

Abstract: A system, arrangement, computer-accessible medium and process are provided for determining information associated with at least one portion of an anatomical structure. For example, an interference between at least one first radiation associated with a radiation directed to the anatomical structure and at least one second radiation associated with a radiation directed to a reference can be detected. Three-dimensional volumetric data can be generated for the at least one portion as a function of the interference. Further, the information can be determined which is at least one geometrical characteristic and/or at least one intensity characteristic of the portion based on the volumetric data.

Abstract: Systems, arrangements and methods for separating an electromagnetic radiation and obtaining information for a sample using an electromagnetic radiation are provided. In particular, the electromagnetic radiation can be separated into at least one first portion and at least one second portion according to at least one polarization and at least one wave-length of the electromagnetic radiation. The first and second separated portions may be simultaneously detected. Further, a first radiation can be obtained from the sample and a second radiation may be obtained from a reference, and the first and second radiations may be combined to form a further radiation, with the first and second radiations being associated with the electro-magnetic radiation. The information is provided as a function of first and second portions of the further radiations that have been previously separated and can be analyzed to extract birefringent information characterizing the sample.