Patents by Inventor Mireille Krier

Mireille Krier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISUBSTITUTED ALKYNE DERIVATIVES
    Publication number: 20230052586
    Abstract: The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.
    Type: Application
    Filed: December 20, 2019
    Publication date: February 16, 2023
    Inventors: Timo Heinrich, Carl Petersson, Mireille Krier, Andrzej Gondela, Michal Mikolaj Galezowski, Charles-Henry Robert Yves Fabritius, Mateusz Oktawian Nowak, Marcin Krol
  • Boronic acid derivatives
    Patent number: 10669289
    Abstract: Compounds of formula (I) are inhibitors of LMP7 and can be employed, inter alia, for the treatment of an autoimmune disorder or hematological malignancies.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: June 2, 2020
    Assignee: MERCK PATENT GMBH
    Inventors: Markus Klein, Oliver Schadt, Philipp Haselmayer, Mireille Krier
  • 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives
    Patent number: 10179777
    Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: January 15, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Dieter Dorsch, Alfred Jonczyk, Mireille Krier
  • Cyclic amides as MetAP-2 inhibitors
    Patent number: 10093623
    Abstract: Described are cyclic amide compounds of the formula (I): in which R1, R3, R5, R6, R7, R, X and Y have the meanings as described. The compounds are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: October 9, 2018
    Assignee: MERCK PATENT GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
  • BORONIC ACID DERIVATIVES
    Publication number: 20180179232
    Abstract: Compounds of formula (I) are inhibitors of LMP7 and can be employed, inter alia, for the treatment of an autoimmune disorder or hematological malignancies.
    Type: Application
    Filed: October 1, 2015
    Publication date: June 28, 2018
    Inventors: MARKUS KLEIN, OLIVER SCHADT, PHILIPP HASELMAYER, MIREILLE KRIER
  • 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES
    Publication number: 20180099947
    Abstract: Compounds of the formula I in which W, R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of ALK1, AL2 and ALK5, and can be employed for the treatment of diseases such as cancer.
    Type: Application
    Filed: March 22, 2016
    Publication date: April 12, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Dieter DORSCH, Alfred JONCZYK, Mireille KRIER
  • Bicyclic heteroaromatic compounds
    Patent number: 9249140
    Abstract: Compounds of the formula I, in which X1, X2, X3, X4, X5, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumors.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: February 2, 2016
    Assignee: MERCK PATENT GMBH
    Inventors: Timo Heinrich, Felix Rohdich, Christina Esdar, Mireille Krier, Hartmut Greiner
  • BICYCLIC HETEROAROMATIC COMPOUNDS
    Publication number: 20150218155
    Abstract: Compounds of the formula I, in which X1, X2, X3, X4, X5, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.
    Type: Application
    Filed: July 26, 2012
    Publication date: August 6, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Timo Heinrich, Felix Rohdich, Christina Esdar, Mireille Krier, Hartmut Greiner
  • CYCLIC AMIDES AS METAP-2 INHIBITORS
    Publication number: 20150031670
    Abstract: Compounds of the formula (I), in which R1, R3, R5, R6, R7, R, X and Y have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Application
    Filed: March 21, 2013
    Publication date: January 29, 2015
    Applicant: MERCK PATENT GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Manja Friese-Hamim, Jeyaprakashnarayanan Seenisamy
  • Pyrrolidone derivatives for use as MetAP-2 inhibitors
    Patent number: 8846694
    Abstract: Compounds of the formula (I), in which R, X, Y, Z, R3 and R4 have the meanings indicated in claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: September 30, 2014
    Assignee: Merck Patent GmbH
    Inventors: Timo Heinrich, Mireille Krier, Thorsten Knoechel, Alfred Jonczyk, Frank Zenke, Holger Enderle
  • Heterocyclic compounds as metap-2 inhibitors
    Patent number: 8546406
    Abstract: Compounds of the formula I, in which D, X, Y, Z, R and R1 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: October 1, 2013
    Assignee: Merck Patent GmbH
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Kai Schiemann
  • 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer
    Patent number: 8530650
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: September 10, 2013
    Assignee: MERCK PATENT GmbH
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier
  • NOVEL HETEROCYCLIC COMPOUNDS AS METAP-2 INHIBITORS
    Publication number: 20110281859
    Abstract: Compounds of the formula I, in which D, X, Y, Z, R and R1 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Application
    Filed: December 22, 2009
    Publication date: November 17, 2011
    Applicant: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Timo Heinrich, Frank Zenke, Mireille Krier, Kai Schiemann
  • Novel pyrrolidone derivatives for use as MetAP-2 inhibitors
    Publication number: 20110263561
    Abstract: Compounds of the formula (I), in which R, X, Y, Z, R3 and R4 have the meanings indicated in claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.
    Type: Application
    Filed: May 13, 2009
    Publication date: October 27, 2011
    Applicant: Merck Patent GmbH
    Inventors: Timo Heinrich, Mireille Krier, Thorsten Knoechel, Alfred Jonczyk, Frank Zenke, Holger Enderle
  • 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER
    Publication number: 20110237583
    Abstract: The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.
    Type: Application
    Filed: November 3, 2009
    Publication date: September 29, 2011
    Inventors: Kai Schiemann, Melanie Schultz, Wolfgang Staehle, Ingo Kober, Dirk Wienke, Mireille Krier