Patents by Inventor Mireille Sebbag

Mireille Sebbag has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides modulating the activity of macrophages, useable for the treatment of rheumatoid arthritis
    Patent number: 9388226
    Abstract: The invention relates to citrulline peptides with anti-inflammatory properties. The invention also relates to an in vitro model for activation of macrophages, induced by immune complexes between specified IgG of rheumatoid arthritis and their citrulline targets.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: July 12, 2016
    Assignee: Universite Paul Sabatier
    Inventors: Cyril Clavel, Mireille Sebbag, Maria Leonor Nogueira, Guy Serre
  • Citrulline peptides derived from fibrin and recognized by rheumatoid arthritis specific autoantibodies, and the use thereof
    Patent number: 9249208
    Abstract: The invention relates to novel citrulline peptides derived from fibrin ? and ? chains which are recognizable by specific citrulline antiprotein autoantibodies (AAPC) of a rheumatoid arthritis (PR) and to the use thereof for detecting the presence of said specific PR AAPC in a biological sample.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: February 2, 2016
    Assignee: Biomerieux
    Inventors: Guy Serre, Mireille Sebbag
  • CITRULLINE PEPTIDES DERIVED FROM FIBRIN AND RECOGNIZED BY RHEUMATOID ARTHRITIS SPECIFIC AUTOANTIBODIES, AND THE USE THEREOF
    Publication number: 20130028922
    Abstract: The invention relates to novel citrulline peptides derived from fibrin ? and ? chains which are recognizable by specific citrulline antiprotein autoantibodies (AAPC) of a rheumatoid arthritis (PR) and to the use thereof for detecting the presence of said specific PR AAPC in a biological sample.
    Type: Application
    Filed: June 5, 2012
    Publication date: January 31, 2013
    Applicant: BIOMERIEUX
    Inventors: Guy Serre, Mireille Sebbag
  • Method for detecting rheumatoid arthritis-specific autoantibodies
    Patent number: 8241856
    Abstract: A method for detecting anti-filaggrin-autoantibodies specific to rheumatoid arthritis in a biological sample, by providing a filaggrin with no citrulline residues (FNC) having an arginine residue or a filaggrin peptide with no citrulline residues (PFNC) having an arginine residue. Also provided are a citrulline-containing filaggrin (FC) having the peptide sequence of the FNC where some arginine residues have been converted to citrulline residues or a citrulline-containing peptide (PFC) having the peptide sequence of the PFNC, where at least one arginine residue has been converted to a citrulline residue. The sample is contacted with the FNC or PFNC and the FC or PFC, and the resulting immune complexes are detected and quantified, with a value XNC and XC, respectively. Anti-filaggrin-autoantibodies specific to rheumatoid arthritis are determined to be present in the biological sample if the value of XC is greater than the value of XNC.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: August 14, 2012
    Assignee: Biomerieux
    Inventors: Brigitte Incaurgarat, Michel Jolivet, Odile Letourneur, Maria Léonor Nogueira, Mireille Sebbag, Guy Serre, Christian Vincent
  • Citrulline peptides derived from fibrin and recognized by rheumatoid arthritis specific autoantibodies, and the use thereof
    Patent number: 8207299
    Abstract: The invention relates to novel citrulline peptides derived from fibrin ? and ? chains which are recognizable by specific citrulline antiprotein autoantibodies (AAPC) of a rheumatoid arthritis (PR) and to the use thereof for detecting the presence of said specific PR AAPC in a biological sample.
    Type: Grant
    Filed: November 3, 2005
    Date of Patent: June 26, 2012
    Assignee: Biomerieux
    Inventors: Guy Serre, Mireille Sebbag
  • Peptides Modulating the Activity of Macrophages, Useable for the Treatment of Rheumatoid Arthritis
    Publication number: 20090298778
    Abstract: The invention relates to citrulline peptides with anti-inflammatory properties. The invention also relates to an in vitro model for activation of macrophages, induced by immune complexes between specified IgG of rheumatoid arthritis and their citrulline targets.
    Type: Application
    Filed: May 3, 2007
    Publication date: December 3, 2009
    Applicant: Universite Paul Sabatier
    Inventors: Cyril Clavel, Mireille Sebbag, Maria Leonor Nogueira, Guy Serre
  • CITRULLINE PEPTIDES DERIVED FROM FIBRIN AND RECOGNIZED BY RHEUMATOID ARTHRITIS SPECIFIC AUTOANTIBODIES, AND THE USE THEREOF
    Publication number: 20090028885
    Abstract: The invention relates to novel citrulline peptides derived from fibrin ? and ? chains which are recognisable by specific citrulline antiprotein autoantibodies (AAPC) of a rheumatoid arthritis (PR) and to the use thereof for detecting the presence of said specific PR AAPC in a biological sample.
    Type: Application
    Filed: November 3, 2005
    Publication date: January 29, 2009
    Inventors: Guy Serre, Mireille Sebbag
  • Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
    Patent number: 7445903
    Abstract: The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: November 4, 2008
    Assignee: Biomerieux SA
    Inventors: Guy Serre, Mireille Sebbag
  • Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
    Publication number: 20070009507
    Abstract: The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
    Type: Application
    Filed: January 26, 2006
    Publication date: January 11, 2007
    Applicant: UNIVERSITE PAUL SABATIER-TOULOUSE III
    Inventors: Guy Serre, Mireille Sebbag
  • Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis
    Patent number: 7022485
    Abstract: The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: April 4, 2006
    Assignee: Universite Paul Sabatier
    Inventors: Guy Serre, Mireille Sebbag
  • Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis
    Patent number: 6890720
    Abstract: The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filaggrin unit or of a related molecule, in which an arginine radical has been substituted by a citrulline radical. The invention also concerns the use of this antigen for diagnosing rheumatoid polyarthritis.
    Type: Grant
    Filed: September 1, 1997
    Date of Patent: May 10, 2005
    Assignee: Biomerieux
    Inventors: Guy Serre, Elisabeth Girbal-Neuhauser, Christian Vincent, Michel Simon, Mireille Sebbag, Pascal Dalbon, Colette Jolivet-Reynaud, Michel Arnaud, Michel Jolivet
  • Method for detecting rheumatoid arthritis-specific autoantibodies
    Publication number: 20040241767
    Abstract: The invention concerns a method for detecting rheumatoid arthritis-specific autoantibodies, in a biological sample suspected of containing said autoantibodies and other autoantibodies not specific of rheumatoid arthritis, comprising the following steps: providing filaggrin (FNC) or a citrulline-containing filaggrin derivative (FNC) or a filaggrin peptide (PFNC) comprising at least an arginine residue and said citrulline-containing filaggrin (FC) or said citrulline-containing filaggrin derivative (FC) or said citrulline-containing peptide (PFC); contacting said biological sample with said filaggrin (FNC) or said filaggrin derivative (FNC) or said peptide (PFNC) and said filaggrin (FC) or said filaggrin derivative (FC) or said peptide (PFC) in conditions suitable for the formation of immune complexes with the autoantibodies; detecting and quantifying the immune complexes formed between the autoantibodies or the other antibodies present in the sample and said filaggrin (FNC) or said filaggrin derivative (FNC) or
    Type: Application
    Filed: January 20, 2004
    Publication date: December 2, 2004
    Inventors: Brigitte Incaurgarat, Michel Jolivet, Odile Letourneur, Maria Leonor Nogueira, Mireille Sebbag, Guy Serre, Christian Vincent