Patents by Inventor Mitchell F. Brin

Mitchell F. Brin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Injection paradigm for administration of botulinum toxins
    Patent number: 10406213
    Abstract: Methods for treating a patient suffering from a medication overuse headache disorder are provided. The methods comprise administering to a patient suffering from a medication overuse disorder a Clostridial toxin. The toxin is administered to the frontalis, corrugator, procerus, occipitalis, temporalis, trapezius and cervical paraspinal muscles of the patient.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: September 10, 2019
    Assignee: Allergan, Inc.
    Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
  • BOTULINUM TOXIN CELL BINDING DOMAIN POLYPEPTIDES AND METHODS OF USE FOR SKIN REJUVENATION
    Publication number: 20190185523
    Abstract: A polypeptide having an amino acid sequence corresponding to a binding domain of a botulinum toxin is described. The polypeptide modulates expression of genes involved in, for example, collagen production and extra cellular matrix organization, and finds use, therefore in modulating skin quality attributes such as elasticity, firmness etc. Moreover, the polypeptide inhibits lipogenesis in specialized cells and finds use, therefore, in reducing skin oiliness, which is frequently observed in skin tissue afflicted with large pores and acne. Nucleic acids encoding the polypeptide, as well as vectors, host cells, and systems comprising the nucleic acids, are further described.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Inventors: Birgitte PS Jacky, Amy Brideau-Andersen, Hui You, Shiazah Z. Malik, Donald E. Frail, Mitchell F. Brin
  • BOTULINUM TOXIN CELL BINDING DOMAIN POLYPEPTIDES AND METHODS OF USE FOR TREATMENTS OF FIBROSIS ASSOCIATED DISORDERS
    Publication number: 20190185837
    Abstract: A polypeptide having an amino acid sequence corresponding to a binding domain of a botulinum toxin is described. The polypeptide modulates expression of genes involved in, for example, collagen production and extra cellular matrix organization, and finds use, therefore in treating or reducing the occurrence of a disease such as a disease of the ECM, a connective or epithelial tissue disease, an endothelial disease or a fibrotic disease, e.g., a fibrotic disease of the ECM, connective tissue, or endothelium. Nucleic acids encoding the polypeptide, as well as vectors, host cells, and systems comprising the nucleic acids, are further described.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 20, 2019
    Inventors: Birgitte PS Jacky, Amy Brideau-Andersen, Hui You, Donald E. Frail, Mitchell F. Brin
  • INJECTION PARADIGM FOR ADMINISTRATION OF BOTULINUM TOXINS
    Publication number: 20190060423
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Application
    Filed: October 29, 2018
    Publication date: February 28, 2019
    Inventors: Andrew M. Blumenfeld, Mitchell F. Brin
  • METHODS FOR TREATING HEADACHE
    Publication number: 20190038726
    Abstract: A headache can be treated more effectively by co-administration of a botulinum toxin and a triptan drug to a patient and/or the effectiveness of a triptan medication can be increased. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of where a patient experiences or is predisposed to experience pain or a headache.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 7, 2019
    Inventors: Catherine C. Turkel, Mitchell F. Brin
  • DISSOLVING FILM FOR DELIVERY OF AN ACTIVE AGENT
    Publication number: 20190000935
    Abstract: A biodegradable film comprising a therapeutically effective amount of a Clostridial neurotoxin is described. Methods for treating rhinitis and for treating a symptom of rhinitis by administering the biodegradable film to the nasal cavity are also described.
    Type: Application
    Filed: June 28, 2018
    Publication date: January 3, 2019
    Inventors: Mitchell F. Brin, Patrick M. Hughes, Guang Wei Lu
  • Injection paradigm for administration of botulinum toxins
    Patent number: 10111938
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: October 30, 2018
    Assignee: Allergan, Inc.
    Inventors: Andrew M. Blumenfeld, Mitchell F. Brin
  • Methods for treating headache
    Patent number: 10092631
    Abstract: A headache can be treated more effectively by co-administration of a botulinum toxin and a triptan drug to a patient and/or the effectiveness of a triptan medication can be increased. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of where a patient experiences or is predisposed to experience pain or a headache.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: October 9, 2018
    Assignee: Allergan, Inc.
    Inventors: Catherine C. Turkel, Mitchell F. Brin
  • Methods for treatment of incontinence associated with sexual activity
    Patent number: 10034923
    Abstract: The invention provides compositions and methods for treating incontinence associated with sexual activity.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: July 31, 2018
    Assignee: Allergan, Inc.
    Inventor: Mitchell F. Brin
  • Injection Paradigm For Administration Of Botulinum Toxins
    Publication number: 20180028624
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Application
    Filed: September 18, 2017
    Publication date: February 1, 2018
    Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
  • Injection paradigm for administration of botulinum toxins
    Patent number: 9764011
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: September 19, 2017
    Assignee: Allergan, Inc.
    Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
  • METHODS FOR TREATING HEADACHE
    Publication number: 20170128552
    Abstract: A headache can be treated more effectively by co-administration of a botulinum toxin and a triptan drug to a patient and/or the effectiveness of a triptan medication can be increased. The botulinum toxin can be botulinum toxin type A and the botulinum toxin can be administered to or to the vicinity of where a patient experiences or is predisposed to experience pain or a headache.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 11, 2017
    Inventors: Catherine C. Turkel, Mitchell F. Brin
  • METHODS FOR TREATMENT OF INCONTINENCE ASSOCIATED WITH SEXUAL ACTIVITY
    Publication number: 20170042984
    Abstract: The invention provides compositions and methods for treating incontinence associated with sexual activity.
    Type: Application
    Filed: October 28, 2016
    Publication date: February 16, 2017
    Inventor: Mitchell F. Brin
  • Methods for treatment of incontinence associated with sexual activity
    Patent number: 9480732
    Abstract: The invention provides compositions and methods for treating incontinence associated with sexual activity.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: November 1, 2016
    Assignee: Allergan, Inc.
    Inventor: Mitchell F. Brin
  • INJECTION PARADIGM FOR ADMINISTRATION OF BOTULINUM TOXINS
    Publication number: 20160263202
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Application
    Filed: March 11, 2016
    Publication date: September 15, 2016
    Inventors: Andrew M. Blumenfeld, Mitchell F. Brin
  • INJECTION PARADIGM FOR ADMINISTRATION OF BOTULINUM TOXINS
    Publication number: 20160175409
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Application
    Filed: March 1, 2016
    Publication date: June 23, 2016
    Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
  • Methods of treating urogenital-neurological disorders using modified Clostridial toxins
    Patent number: 9370548
    Abstract: The present specification discloses modified Clostridial toxins, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such modified Clostridial toxins and compositions.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: June 21, 2016
    Assignee: Allergan, Inc.
    Inventors: Mitchell F. Brin, Joseph Francis, Kei Roger Aoki
  • Injection paradigm for administration of botulinum toxins
    Patent number: 9279001
    Abstract: Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a fixed site/fixed dose and an optional follow the pain variable dosage and injection site paradigm is disclosed for optimizing clinical effectiveness of botulinum toxin administration for patients suffering headache, particularly chronic migraine.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: March 8, 2016
    Assignee: Allergan, Inc.
    Inventors: Catherine C. Turkel, Sheena K. Aurora, Mitchell F. Brin
  • METHODS FOR TREATMENT OF INCONTINENCE ASSOCIATED WITH SEXUAL ACTIVITY
    Publication number: 20160008441
    Abstract: The invention provides compositions and methods for treating incontinence associated with sexual activity.
    Type: Application
    Filed: September 25, 2015
    Publication date: January 14, 2016
    Inventor: Mitchell F. Brin
  • Methods for treatment of incontinence associated with sexual activity
    Patent number: 9144600
    Abstract: The invention provides compositions and methods for treating incontinence associated with sexual activity.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: September 29, 2015
    Assignee: Allergan, Inc.
    Inventor: Mitchell F. Brin