Patents by Inventor Mitsuaki Tsunakawa
Mitsuaki Tsunakawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6424980Abstract: An integrated retrieval scheme retrieves data involved in a plurality of semi-structured documents scattering over open networks and collects the required information item by item from the semi-structured documents through a unified interface without regard to differences in the document structures, presentation styles, and elements of the semi-structured documents. The search scheme receives a query consisting of search items and search conditions from a user.Type: GrantFiled: June 9, 1999Date of Patent: July 23, 2002Assignee: Nippon Telegraph and Telephone CorporationInventors: Yuichi Iizuka, Mitsuaki Tsunakawa, Toshihiro Nagasue, Takashi Hoshino, Hiroki Machihara
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Patent number: 5919671Abstract: The present invention relates to the novel antitumor antibiotic designated BMS-199687 and to its preparation. The compound is obtained by culturing a new strain of Actinomadura ferruginea. BMS-199687 demonstrates antitumor activity in standard antitumor animal model systems.Type: GrantFiled: February 13, 1998Date of Patent: July 6, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Mitsuaki Tsunakawa, Li-Ping Chang, Stephen W. Mamber, Isia Bursuker, Robert Hugill
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Patent number: 5811440Abstract: The present invention relates to the novel antitumor antibiotic designated BMS-199687 and to its preparation. The compound is obtained by culturing a new strain of Actinomadura ferruginea. BMS-199687 demonstrates antitumor activity in standard antitumor animal model systems.Type: GrantFiled: April 2, 1997Date of Patent: September 22, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Mitsuaki Tsunakawa, Li-Ping Chang, Stephen W. Mamber, Isia Bursuker, Robert Hugill
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Patent number: 5639735Abstract: Hayumicin compounds, obtainable by cultivation of a strain of Actinomadura sp. designated ATCC 55432, and analogs of these compounds. The novel compounds have antitumor as well as antibiotic, particularly antibacterial, activity.Type: GrantFiled: September 19, 1994Date of Patent: June 17, 1997Assignee: Bristol-Myers Squibb CompanyInventors: Rolf Menzel, Scott T. Taylor, Mitsuaki Tsunakawa, Keiichi Numata, Tamotsu Furumai
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Patent number: 5466450Abstract: A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.Type: GrantFiled: July 20, 1993Date of Patent: November 14, 1995Assignee: Bristol-Myers Squibb Co.Inventors: Mitsuaki Tsunakawa, Tetsuro Yamasaki, Koji Tomita, Osamu Tenmyo
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Patent number: 5286649Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.Type: GrantFiled: January 10, 1992Date of Patent: February 15, 1994Assignee: Bristol-Myers Squibb Co.Inventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
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Patent number: 5256646Abstract: A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.Type: GrantFiled: July 27, 1990Date of Patent: October 26, 1993Assignee: Bristol-Myers Squibb CompanyInventors: Mitsuaki Tsunakawa, Tetsuro Yamasaki, Koji Tomita, Osamu Tenmyo
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Patent number: 5124150Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.Type: GrantFiled: March 11, 1991Date of Patent: June 23, 1992Assignee: Bristol-Myers Squibb Co.Inventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
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Patent number: 5110960Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.Type: GrantFiled: October 1, 1990Date of Patent: May 5, 1992Assignee: Bristol-Myers CompanyInventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
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Patent number: 5098708Abstract: Production of an antiviral antibiotic complex, BU-3889V and its bioactive components A.sub.1, A.sub.2, A.sub.3, D.sub.1, D.sub.2 and D.sub.3, by fermentation of a BU-3889V producing strain of the new microorganism Amycolatopsis orientalis ATCC-53884 is disclosed. Complex BU-3889V is recovered and the components separated by the use of ion exchange chromatography techniques. The bioactive components are characterized by their physico-chemical characterizing properties. The products have been found to be effective to inhibit viruses including herpes simplex virus, human immunodeficiency virus (HIV) and influenza virus.Type: GrantFiled: July 6, 1990Date of Patent: March 24, 1992Assignee: Bristol-Myers Squibb CompanyInventors: Masataka Konishi, Mitsuaki Tsunakawa, Osamu Tenmyo, Takeo Miyaki, Toshikazu Oki
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Patent number: 4990497Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.Type: GrantFiled: June 15, 1989Date of Patent: February 5, 1991Inventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
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Patent number: 4935362Abstract: A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K7331-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.Type: GrantFiled: March 30, 1987Date of Patent: June 19, 1990Assignee: Bristol-Myers CompanyInventors: Mitsuaki Tsunakawa, Masataka Konishi, Takeo Miyaki
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Patent number: 4870165Abstract: Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.Type: GrantFiled: November 2, 1987Date of Patent: September 26, 1989Assignee: Bristol-Myers CompanyInventors: Toshikazu Oki, Kyoichiro Saitoh, Kozo Tomatsu, Koji Tomita, Masataka Konishi, Takeo Miyaki, Mitsuaki Tsunakawa, Maki Nishio
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Patent number: 4792545Abstract: Boholmycin antibiotic is prepared by fermentation of Streptomyces hygroscopicus H617-25 (ATCC No. 53240) in a nutrient medium preferably comprising glycerol, bacto-liver, cornsteep liquor, ammonium sulfate, sodium chloride and calcium carbonate. The antibiotic and pharmaceutically acceptable salts and hydrates thereof and compositions containing these are effective against Gram-positive, Gram-negative and acid-fast bacteria and against bacterial strains which are resistant to previously known aminoglycoside antibiotics and are useful to treat bacterial infections in mammals.Type: GrantFiled: January 8, 1986Date of Patent: December 20, 1988Assignee: Bristol-Myers CompanyInventors: Kyoichiro Saitoh, Mitsuaki Tsunakawa, Masataka Konishi, Takeo Miyaki
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Patent number: 4683230Abstract: A new antitumor antibiotic designated herein as BMY-28121 is produced by fermentation of Streptomyces albus strain K731-113 (ATCC 39897). BMY-28121, which may be recovered from the fermentation broth in either its natural free hydroxy form (BMY-28121A) or methyl ether form (BMY-28121B), inhibits gram-positive bacteria and anaerobes and inhibits the growth of mammalian tumors such as P-388 leukemia, L-1210 leukemia and B16 melanoma.Type: GrantFiled: February 25, 1985Date of Patent: July 28, 1987Assignee: Bristol-Myers CompanyInventors: Mitsuaki Tsunakawa, Masataka Konishi, Takeo Miyaki
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Patent number: 4504580Abstract: Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.Type: GrantFiled: June 23, 1983Date of Patent: March 12, 1985Assignee: Bristol-Myers CompanyInventors: Minoru Hanada, Mitsuaki Tsunakawa, Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi
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Patent number: 4468386Abstract: Antibiotic Bu-2659 complex, containing components A, B, C, D and E, is produced by cultivation of Streptomyces hygroscopicus Strain No. J296-21, ATCC No. 39150.Type: GrantFiled: August 19, 1982Date of Patent: August 28, 1984Assignee: Bristol-Myers CompanyInventors: Minoru Hanada, Mitsuaki Tsunakawa, Koji Tomita, Hiroshi Tsukiura, Hiroshi Kawaguchi