Patents by Inventor Mitsugu Hachisu
Mitsugu Hachisu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6451800Abstract: An objective of the present invention is to provide compounds having integrin &agr;v&bgr;3 antagonistic activity, GP IIb/IIIa antagonistic activity, and/or human platelet aggregation inhibitory activity, and therapeutic agents for treating integrin &agr;v&bgr;3-mediated diseases and for inhibiting platelet aggregation. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein A represents a five- to seven-membered heterocyclic ring containing two nitrogen atoms or the like; X and Z represent CH or a nitrogen atom; R4 and R5 represent alkyl, halogen or the like; Q represents >C=O, >CH2 or the like; R6 represents H, alkyl, aralkyl or the like; R7 represents H, alkynyl or the like; R8 represents H, substituted amino or the like; R9 represents H or alkyl; m is 0 to 5; n is 0 to 4; p is 2 or 3; and q is 0 or 1.Type: GrantFiled: July 28, 2000Date of Patent: September 17, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Keiichi Ajito, Shoichi Murakami, Minoru Ishikawa, Mikio Yamamoto, Dai Kubota, Shuichi Gomi, Mitsugu Hachisu, Kiyoaki Katano
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Patent number: 6420558Abstract: An objective of the present invention is to provide compounds having integrin &agr;v&bgr;3 antagonistic activity, cell adhesion inhibitory activity, GP IIb/IIIa antagonistic activity, and/or human platelet aggregation inhibitory activity, and, therapeutic agents for treating cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases and the like and for inhibiting platelet aggregation.Type: GrantFiled: October 10, 2000Date of Patent: July 16, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Minoru Ishikawa, Shoichi Murakami, Mikio Yamamoto, Dai Kubota, Mitsugu Hachisu, Kiyoaki Katano, Keiichi Ajito
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Patent number: 6063779Abstract: An objective of the present invention is to provide a compound that has antiarrhythmic activity. The present invention provides a compound of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each represent H, halogen or lower alkyl which may be substituted by halogen; A represents H, C3-6 cycloalkyl, phenyl which may be substituted by halogen, nitro, or lower alkoxy, a 5-membered or 6-membered heterocyclic ring which may contain N and/or S, --NR.sup.3 R.sup.4 (wherein R.sup.3 and R.sup.4 each represent H or lower alkyl which may be substituted by phenyl), or COR.sup.5 (wherein R.sup.5 represents OH, amino or lower alkoxy); Q represents S or O; m represents 0-18; and n represents 0-2, and pharmaceutically acceptable salts and solvates thereof.Type: GrantFiled: May 15, 1998Date of Patent: May 16, 2000Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kiyoaki Katano, Takahiko Satoh, Tomoko Soneda, Naoko Kamitoh, Kazuyuki Fujishima, Mitsugu Hachisu
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Patent number: 5232947Abstract: New N,N-di-alkyl- or alkenyl-substituted derivatives of oxamic acid of which the two alkyl or alkenyl groups are different from each other are now produced and found to exhibit the cerebral protective effect against cerebral anoxia in the brain of a mammalian animal, including human, and to be useful as an agent for improving or ameliorating the damaged or disturbed functions of the brain. Some known N,N-di-alkyl-substituted derivatives of oxamic acid or which the two alkyl groups are identical to each other are now also found to have similar, cerebral protective effect against cerebral anoxia and to be useful as an agent for improving the damaged functions of the brain.Type: GrantFiled: September 4, 1991Date of Patent: August 3, 1993Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasuo Sato, Shinsuke Katoh, Kunio Atsumi, Mitsugu Hachisu, Seiji Shibahara
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Patent number: 5206384Abstract: A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.Type: GrantFiled: September 4, 1991Date of Patent: April 27, 1993Assignees: Zaidan Hojin Biseibutsu Kagaku Kai, Meiji Seika Kaisha Ltd.Inventors: Seiji Shibahara, Yoshiyuki Koyama, Shigeharu Inoue, Mitsugu Hachisu, Shinichi Kondo, Takaaki Aoyagi, Tomio Takeuchi
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Patent number: 5132454Abstract: A method of inhibiting the abnormal postnatal axial growth of the eye of a maturing animal during conditions ordinarily leading to said abnormal growth, which comprises (1) determining the neurochemical present in the retina of said eye, e.g., dopamine, the concentration of which is reduced during said conditions, and (2) administering to said eye during postnatal maturation effective amounts of said neurochemical, its agonist or its antagonist.Type: GrantFiled: February 28, 1991Date of Patent: July 21, 1992Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasuo Sato, Shinsuke Kato, Takako Taniguchi, Kunio Atsumi, Mitsugu Hachisu, Seiji Shibahara
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Patent number: 5066677Abstract: Novel N-(dialkylaminoalkyl)-substituted derivatives or N-(dialkylaminoalkyl)-N-alkyl-substituted derivatives of oxamic acid are now synthetized and found to exhibit the cerebral protective effect against cerebral anoxia in brain of a mammalian animal, including human, and to be useful as an agent for improving or ameliorating the damaged or disturbed functions of the brain.Type: GrantFiled: July 6, 1990Date of Patent: November 19, 1991Assignee: Meiji Seika Kaisha, Ltd.Inventors: Yasuo Sato, Shinsuke Kato, Takako Taniguchi, Kunio Atsumi, Mitsugu Hachisu, Seiji Shibahara
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Patent number: 4929633Abstract: As new compounds are provided a class of derivatives of actinonin represented by the general formula ##STR1## where R is a hydrogen or a lower alkyl group, which can exhibit the enzyme-inhibitory activities to a limited range of peptidases and show a remarkable enzyme-specificity, and which are effective to treat a cycloheximide-induced experimental amnesia in mice and are expectable to be useful to treat an amnesia in a mammalian animal, including human.Type: GrantFiled: June 8, 1988Date of Patent: May 29, 1990Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Meiji Seika Kaisha, Ltd.Inventors: Seiji Shibahara, Yukiko Takahashi, Yuji Matsuhashi, Mitsugu Hachisu, Shinichi Kondo, Tomio Takeuchi, Takaaki Aoyagi
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3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives and an analgesic agent comprising the same
Patent number: 4719231Abstract: New 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives are now provided, which exhibit analgesic activity and are effective to enhance the analgesia induced by a known analgesic compound, ]D-ala.sup.2,met.sup.5 ]-enkephalin (DAME).Type: GrantFiled: May 20, 1985Date of Patent: January 12, 1988Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Mitsugu Hachisu, Masao Hirayama, Shinjiro Murata, Shunzo Fukatsu -
Patent number: 4474764Abstract: New 3-N-acyl derivatives of 3-amino-2-hydroxy-4-phenylbutanoic acid are provided, which exhibit analgesic activity and are affective to enhance the morphine analgesia.Type: GrantFiled: September 28, 1982Date of Patent: October 2, 1984Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Mitsugu Hachisu, Kenji Kawamura, Shunzo Fukatsu, Yasuharu Sekizawa
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Patent number: 4418070Abstract: A 5-phenylthiazole derivative represented by the formula: ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a hydroxyl group, an amino group or a mercapto group, or a pharmaceutically acceptable salt thereof shows a cardiac effect and a low toxicity to a human or animal with little influence on atrium rhythms.Type: GrantFiled: February 4, 1982Date of Patent: November 29, 1983Assignee: Meiji Seika Kabushiki KaishaInventors: Tsuneo Okonogi, Shunzo Fukatsu, Mitsugu Hachisu, Hiroko Kawashima, Keiko Shitoh, Yasuharu Sekizawa
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Patent number: 4395402Abstract: A new analgesic agent is now provided, which comprises as the active ingredient 3-amino-2-hydroxy-4-phenylbutanoic acid and some related compounds thereof. These compounds have now found to be effective as inhibitor against enkephalinase and as an agent for enhancing analgesic activity of morphine.Type: GrantFiled: September 21, 1981Date of Patent: July 26, 1983Assignee: Zaidan Hojin Biseibutsu Kagaku Kankyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Mitsugu Hachisu, Kenji Kawamura, Shunzo Fukatsu, Yasuharu Sekizawa
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Patent number: 4229448Abstract: 5-Substituted picolinic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents a straight or branched chain halogen-substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R.sub.3 and R.sub.4, when taken together, represent a polymethylene chain; and R.sub.Type: GrantFiled: March 23, 1979Date of Patent: October 21, 1980Assignee: Meuji Seika Kaisha Ltd.Inventors: Yasuharu Sekizawa, Takashi Tsuruoka, Mitsugu Hachisu, Masaji Sezaki, Masashi Miyamoto, Uichi Shibata, Kazuko Mizutani, Shigeharu Inouye, Takemi Koeda, Keizo Shimomura, Taro Niida
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Patent number: 4198416Abstract: 5-Alkoxy-picolinic esters represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and R.sub.1 represents an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms or an acetyl group; a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an alkoxyalkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an indanyl group; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc.Type: GrantFiled: September 22, 1978Date of Patent: April 15, 1980Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takemi Koeda, Takashi Tsuruoka, Uichi Shibata, Hiroyasu Asaoka, Mitsugu Hachisu, Osamu Itoh, Yasuharu Sekizawa, Shigeharu Inouye, Taro Niida
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Patent number: 4189489Abstract: 5-Alkoxy-picolinic acids and the salts and the esters thereof represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and M represents a hydrogen atom; a calcium atom; a sodium atom; a potassium atom; an aluminum atom; an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as a chlorine, bromine, iodine, etc., atom); a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc.Type: GrantFiled: September 30, 1977Date of Patent: February 19, 1980Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takemi Koeda, Takashi Tsuruoka, Uichi Shibata, Hiroyasu Asaoka, Mitsugu Hachisu, Osamu Itoh, Yasuharu Sekizawa, Shigeharu Inouye, Taro Niida