Patents by Inventor Mitsuhiro Ino
Mitsuhiro Ino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130095068Abstract: Provided is an imidazolylbenzene compound or salt thereof that controls HCV replication and in addition is particularly capable of strongly controlling HCV replication, and is very effective in the prevention and treatment of HCV infection when used in combination with another agent for treating HCV infection such as Interferon.Type: ApplicationFiled: June 14, 2011Publication date: April 18, 2013Applicant: EISAI R&D MANAGEMENT CO., LTD.Inventors: Mamoru Yanagimachi, Mitsuhiro Ino
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Patent number: 7772249Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.Type: GrantFiled: March 3, 2009Date of Patent: August 10, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Yoshinori Takahashi, Yorihisa Hoshino, Koichi Kikuchi, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Patent number: 7625925Abstract: Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.Type: GrantFiled: June 4, 2007Date of Patent: December 1, 2009Assignee: Eisai R&D Management Co., LtdInventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Publication number: 20090181985Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.Type: ApplicationFiled: March 3, 2009Publication date: July 16, 2009Applicant: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Yoshinori Takahashi, Yorihisa Hoshino, Koichi Kikuchi, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Matsuko Ono, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Publication number: 20080076943Abstract: A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.Type: ApplicationFiled: September 20, 2007Publication date: March 27, 2008Inventors: Shigeki HIBI, Yorihisa HOSHINO, Koichi KIKUCHI, Kogyoku SHIN, Yoshinori TAKAHASHI, Masae FUJISSAWA, Hisashi SHIBATA, Mitsuhiro INO
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Patent number: 7323569Abstract: A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.Type: GrantFiled: October 22, 2003Date of Patent: January 29, 2008Assignee: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kogyoku Shin, Yoshinori Takahashi, Masae Fujisawa, Hisashi Shibata, Mitsuhiro Ino
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Publication number: 20070249663Abstract: Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.Type: ApplicationFiled: June 4, 2007Publication date: October 25, 2007Inventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Patent number: 7285666Abstract: Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.Type: GrantFiled: June 5, 2006Date of Patent: October 23, 2007Assignee: Eisai R&D Management Co., Ltd.Inventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Patent number: 7176216Abstract: A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.Type: GrantFiled: October 21, 2003Date of Patent: February 13, 2007Assignee: Eisai Co., Ltd.Inventors: Shigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kogyoku Shin, Yoshinori Takahashi, Masae Fujisawa, Hisashi Shibata, Mitsuhiro Ino
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Publication number: 20060235011Abstract: A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.Type: ApplicationFiled: October 22, 2003Publication date: October 19, 2006Applicant: Eisai Co.Ltd.Inventors: Shigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kyogyoku Shin, Yoshinori Takahashi, Masae Fujisawa, Hisashi Shibata, Mitsuhiro Ino
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Publication number: 20060217348Abstract: Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.Type: ApplicationFiled: June 5, 2006Publication date: September 28, 2006Inventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Publication number: 20060211696Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.Type: ApplicationFiled: June 1, 2006Publication date: September 21, 2006Inventors: Shigeki HIBI, Yoshinori Takahashi, Yorihisa Hoshino, Koichi Kikuchi, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Patent number: 7091215Abstract: Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.Type: GrantFiled: April 25, 2002Date of Patent: August 15, 2006Assignee: Eisai Co., Ltd.Inventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa
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Patent number: 7078405Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.Type: GrantFiled: February 8, 2002Date of Patent: July 18, 2006Assignee: Eisai Co., Ltd.Inventors: Shigeki Hibi, Yoshinori Takahashi, Yorihisa Hoshino, Koichi Kikuchi, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Hisashi Shibata, Mitsuhiro Ino
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Patent number: 7067714Abstract: A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological action on blood pressure control, transmission of pain, blood sugar level control and so forth by using the animal.Type: GrantFiled: October 26, 2000Date of Patent: June 27, 2006Assignee: Eisai Research InstituteInventors: Mitsuhiro Ino, Norimasa Miyamoto, Eiki Takahashi, Toru Oki, Takashi Yoshinaga, Shinji Hatakeyama, Tetsuhiro Niidome, Kohei Sawada, Yukio Nishizawa, Isao Tanaka
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Patent number: 6995163Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof, wherein R2 is a hydrogen atom, etc.; R3 is a hydrogen atom, etc.; M? represents a hydrogen atom, a halogen atom or a C1-6 alkyl group; R7? represents a hydrogen atom or a C1-6 alkyl group; and W? represents a phenyl group, pyridyl group, thienyl group, or furyl group, each being optionally substituted; and a pharmacologically acceptable salt thereof or hydrates thereof.Type: GrantFiled: August 2, 2004Date of Patent: February 7, 2006Assignee: Eisai Co., Ltd.Inventors: Shigeki Hibi, Yorihisa Hoshino, Tatsuya Yoshiuchi, Kogyoku Shin, Kouichi Kikuchi, Motohiro Soejima, Mutsuko Tabata, Yoshinori Takahashi, Hisashi Shibata, Takayuki Hida, Tetsuya Hirakawa, Mitsuhiro Ino
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Publication number: 20050004159Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR1R2)m— (wherein R1 and R2 are the same as or different from each other and each represents a C1-6 alkyl group etc.), —NR3— (wherein R3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR6R7)p— (wherein R6 and R7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C1-6 alkyl group optionally substituted with a halogen atom, etc.Type: ApplicationFiled: August 2, 2004Publication date: January 6, 2005Inventors: Shigeki Hibi, Yorihisa Hoshino, Tatsuya Yoshiuchi, Kogyoku Shin, Kouichi Kikuchi, Motohiro Soejima, Mutsuko Tabata, Yoshinori Takahashi, Hisashi Shibata, Takayuki Hida, Tetsuya Hirakawa, Mitsuhiro Ino
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Publication number: 20050004147Abstract: The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR1R2)m— (wherein R1 and R2 are the same as or different from each other and each represents a C1-6 alkyl group etc.), —NR3— (wherein R3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR6R7)p— (wherein R6 and R7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C1-6 alkyl group optionally substituted with a halogen atom, etc.Type: ApplicationFiled: August 2, 2004Publication date: January 6, 2005Inventors: Shigeki Hibi, Yorihisa Hoshino, Tatsuya Yoshiuchi, Kogyoku Shin, Kouichi Kikuchi, Motohiro Soejima, Mutsuko Tabata, Yoshinori Takahashi, Hisashi Shibata, Takayuki Hida, Tetsuya Hirakawa, Mitsuhiro Ino
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Publication number: 20040224974Abstract: A compound represented by the formula: 1Type: ApplicationFiled: October 21, 2003Publication date: November 11, 2004Inventors: Shigeki Hibi, Yorihisa Hoshino, Koichi Kikuchi, Kogyoku Shin, Yoshinori Takahashi, Masae Fujisawa, Hisashi Shibata, Mitsuhiro Ino
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Publication number: 20040122039Abstract: Compounds represented by the general formula: 1Type: ApplicationFiled: October 27, 2003Publication date: June 24, 2004Inventors: Shigeki Hibi, Koichi Kikuchi, Yorihisa Hoshino, Motohiro Soejima, Tatsuya Yoshiuchi, Kogyoku Shin, Mutsuko Ono, Yoshinori Takahashi, Hisashi Shibata, Mitsuhiro Ino, Tetsuya Hirakawa