Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: The operating system for a construction machine gives advice on efficient operation to an operator. A specified state value relating to the operational condition of the construction machine, for example, the hydraulic oil pressure or engine speed, is detected (S101), and the frequency distribution of the state value in prescribed time intervals is calculated (S102). The variable range of the state value is classified into plural regions beforehand, and different target values are pre-set for each these regions. For each region, the frequency distribution is compared with the target value (S104, 106, 108, 110, 112), and as a result of the comparison, a applicable message is selected from the prescribed messages and output (S105, 107, 109, 111, 113). The output message may also be selected according to the combination of the comparison results for the plural state values such as the hydraulic oil pressure and engine speed.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion. Also provided are crystalline forms of FR901228, e.g., type A and type B crystalline forms of FR901228.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion. Also provided are crystalline forms of FR901228, e.g., type A and type B crystalline forms of FR901228.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: To provide a construction machine capable of encouraging an operator to perform the driving and the operation for enhancing fuel efficiency. The construction machine includes information providing means 30 to notify the operator of the information such as the operation and/or an operational method or the like to enhance the fuel efficiency. The present construction machine provides the information by monitor display on a monitor screen 26 that is provided in an operator's cabin 11. When operating machine levers 19 and 20 are positioned at a neutral position, if an engine 40 has the idle revolution number not less than a predetermined time, the information providing means 30 provides the information such as the operation or the like to enhance the fuel efficiency.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: Construction machinery is capable of prompting an operator to control or operate the machinery to improve fuel consumption. The fuel consumption per time or the fuel consumption per work amount is measured, and an image showing a difference between the measured fuel consumption per time and a set fuel consumption per time or between the measured fuel consumption per work amount and a set fuel consumption per work amount is displayed on a display device (30). When the measured fuel consumption per time is larger than the preset fuel consumption per time or the measured fuel consumption per work amount is larger than the set fuel consumption per work amount, an indication for prompting the operator to improve the fuel consumption is displayed on the display device (30).

Abstract: The operating system for a construction machine gives advice on efficient operation to an operator. A specified state value relating to the operational condition of the construction machine, for example, the hydraulic oil pressure or engine speed, is detected (S101), and the frequency distribution of the state value in prescribed time intervals is calculated (S102). The variable range of the state value is classified into plural regions beforehand, and different target values are pre-set for each these regions. For each region, the frequency distribution is compared with the target value (S104, 106, 108, 110, 112), and as a result of the comparison, a applicable message is selected from the prescribed messages and output (S105, 107, 109, 111, 113). The output message may also be selected according to the combination of the comparison results for the plural state values such as the hydraulic oil pressure and engine speed.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.

Abstract: To provide a construction machine capable of encouraging an operator to perform the driving and the operation for enhancing fuel efficiency. The construction machine includes information providing means 30 to notify the operator of the information such as the operation and/or an operational method or the like to enhance the fuel efficiency. The present construction machine provides the information by monitor display on a monitor screens 26 that is provided in an operator's cabin 11. When operating machine levers 19 and 20 are positioned at a neutral position, if an engine 40 has the idle revolution number not less than a predetermined time, the information providing means 30 provides the information such as the operation or the like to enhance the fuel efficiency.

Abstract: Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant.

Abstract: A construction machine capable of notifying an operator or the like of an energy saving state such that an engine thereof stops irrespective of the operator's will. The construction machine, wherein its engine is controlled to be in an energy saving state when an operator leaves from an operator's seat and no work is performed, includes various display devices for displaying the energy saving state. The various display devices include a display lamp that is capable of being recognized from the outside of the machine, and a monitor screen that is provided in an operator's cabin as a monitor display.