Abstract: A microparticle dispersion liquid manufacturing apparatus 10 includes a controller 11, a light source 12, an irradiation optical system 13, and a container 14. A solid object 1 is contained in and a solvent 2 is injected into an interior of the container 14 to enable attainment of a state where the solid object 1 is in contact with the solvent 2. The light source 12 repeatedly outputs pulsed light. By repeatedly irradiating the solvent 2 with the pulsed light from the light source 12, expansion and contraction of the solvent 2 is made to occur repeatedly at the irradiated portion, thereby generating a pressure wave in the solvent 2, and the pressure wave is made to act on the solid object 1 to finely pulverize the solid object 1 and thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent.

Abstract: A method and an apparatus enabling manufacture of a microparticle dispersion liquid at high efficiency in a short time while suppressing drug degradation, etc., are provided. In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent in a container 13. In a fixing step following the dissolving step, the organic solvent, contained in a solution, is eliminated by evaporation, a pellet-form residue 1 is obtained by the organic solvent elimination, and the residue 1 is fixed on an inner wall of the container 13. In a water injecting step following the fixing step, water 2 is injected into an interior of the container 13.

Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.

Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.

Abstract: A microparticle dispersion liquid manufacturing apparatus 10 includes a controller 11, a light source 12, an irradiation optical system 13, and a container 14. A solid object 1 is contained in and a solvent 2 is injected into an interior of the container 14 to enable attainment of a state where the solid object 1 is in contact with the solvent 2. The light source 12 repeatedly outputs pulsed light. By repeatedly irradiating the solvent 2 with the pulsed light from the light source 12, expansion and contraction of the solvent 2 is made to occur repeatedly at the irradiated portion, thereby generating a pressure wave in the solvent 2, and the pressure wave is made to act on the solid object 1 to finely pulverize the solid object 1 and thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent.

Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues are obtained by the organic solvent removal, and the residues are fixed on respective bottom surfaces of a plurality of locations of a container. In a water injecting step, water is injected into each of a plurality of recesses of the container. In an irradiating step, laser light L, emitted from a light irradiating unit, is irradiated simultaneously or successively on the residues fixed on the respective bottom surfaces of the recesses of the container, and the residues are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured.

Abstract: In a dissolving step, in a container 13, a poorly soluble drug and a dispersion stabilizer (polyvinylpyrrolidone and sodium lauryl sulfate) are dissolved in a volatile organic solvent. In a solid composition forming step following the dissolving step, the organic solvent contained in the solution is removed by evaporation, and by the organic solvent removal, a solid composition 1 is obtained as a residue, and the solid composition 1 becomes fixed on the inner wall of the container 13. In a water injecting step following the solid composition forming step, water 2 is injected into the interior of the container 13. In a microparticle dispersion liquid preparing step following the water injecting step, laser light L emitted from a laser light source 11 is irradiated on the solid composition 1 fixed on the inner wall of the container 13 and optical energy is thereby applied to the solid composition 1.

Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.

Abstract: A to-be-treated body, which contains raw material particles 5 of a substance and with which a solvent 4 of a to-be-treated liquid 2 is made solid, is used, and a laser light source 10, which supplies a laser light of a predetermined wavelength to a treatment chamber 3 that contains the to-be-treated body, is provided to arrange a production apparatus 1A. The laser light from the laser light source 10 is illuminated onto the to-be-treated body to microparticulate the substance in solvent 4. As the to-be-treated body of solid form, a solidified body 6, with which water 4 is solidified by a cooling device 50 and the solidified state is maintained by a thermally insulating layer 30, may be used. Or, as the to-be-treated body, a gel body, with which the solvent is gelled, may be used. The substance can thereby microparticulated efficiently by photo-pulverization.

Abstract: With this invention, in a nanoparticle production method, wherein nanoparticles are produced by irradiating a laser light irradiation portion 2a of a to-be-treated liquid 8 with a laser light, in which suspended particles are suspended, to pulverize the suspended particles in laser light irradiation portion 2a, laser light irradiation portion 2a of to-be-treated liquid 8 is cooled. In this case, by the cooling of to-be-treated liquid 8, the respective suspended particles are cooled in their entireties. When the portion 2a of this to-be-treated liquid 8 is irradiated with the laser light, the laser light is absorbed at the surfaces of the suspended particles at portion 2a. Since to-be-treated liquid 8 is cooled during this process, significant temperature differences arise between the interiors and surfaces of the suspended particles and between the surfaces of the suspended particles and the to-be-treated liquid at laser light irradiation portion 2a, and highly efficient nanoparticulation is realized.

Abstract: An apparatus 1A for processing carbon nanotubes (CNTs) includes: a processing chamber 3 for housing to-be-processed liquid 2 with CNT raw material 5 to be fragmented being suspended in a solvent 4; and a pulse irradiation light source 10 for applying pulse light having a predetermined wavelength for fragmentation of the CNTs in the solvent 4 to the to-be-processed liquid 2 housed in the processing chamber 3. This achieves a method and apparatus for processing carbon nanotubes that can fragment CNTs efficiently, and carbon nanotube dispersion liquid and carbon nanotube powder produced by the same.

Abstract: An apparatus 1A for processing carbon nanotubes (CNTs) includes: a processing chamber 3 for housing to-be-processed liquid 2 with CNT raw material 5 to be fragmented being suspended in a solvent 4; and a pulse irradiation light source 10 for applying pulse light having a predetermined wavelength for fragmentation of the CNTs in the solvent 4 to the to-be-processed liquid 2 housed in the processing chamber 3. This achieves a method and apparatus for processing carbon nanotubes that can fragment CNTs efficiently, and carbon nanotube dispersion liquid and carbon nanotube powder produced by the same.

Abstract: A production apparatus which includes: a treatment chamber, containing a to-be-treated liquid, made up of water, which is a solvent, and raw material particles of a substance; a laser light source, illuminating laser light for microparticulation onto the to-be-treated liquid; an ultrasonic transducer, irradiating ultrasonic waves for preventing aggregation of microparticles; and a controlling device, controlling the laser light illumination by the laser light source and the ultrasonic wave irradiation by the ultrasonic transducer. A vibration amplitude of the treatment chamber is monitored by means of a microphone and a vibration amplitude measuring device to set the frequency of the ultrasonic waves to a resonance vibration frequency. A microparticle production method and production apparatus that enable substances to be microparticulated efficiently by photo-pulverization, and microparticles are thus realized.

Abstract: A method and an apparatus enabling manufacture of a microparticle dispersion liquid at high efficiency in a short time while suppressing drug degradation, etc., are provided. In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent in a container 13. In a fixing step following the dissolving step, the organic solvent, contained in a solution, is eliminated by evaporation, a pellet-form residue 1 is obtained by the organic solvent elimination, and the residue 1 is fixed on an inner wall of the container 13. In a water injecting step following the fixing step, water 2 is injected into an interior of the container 13.

Abstract: In a dissolving step, in a container 13, a poorly soluble drug and a dispersion stabilizer (polyvinylpyrrolidone and sodium lauryl sulfate) are dissolved in a volatile organic solvent. In a solid composition forming step following the dissolving step, the organic solvent contained in the solution is removed by evaporation, and by the organic solvent removal, a solid composition 1 is obtained as a residue, and the solid composition 1 becomes fixed on the inner wall of the container 13. In a water injecting step following the solid composition forming step, water 2 is injected into the interior of the container 13. In a microparticle dispersion liquid preparing step following the water injecting step, laser light L emitted from a laser light source 11 is irradiated on the solid composition 1 fixed on the inner wall of the container 13 and optical energy is thereby applied to the solid composition 1.

Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.

Abstract: With this invention, in a nanoparticle production method, wherein nanoparticles are produced by irradiating a laser light irradiation portion 2a of a to-be-treated liquid 8 with a laser light, in which suspended particles are suspended, to pulverize the suspended particles in laser light irradiation portion 2a, laser light irradiation portion 2a of to-be-treated liquid 8 is cooled. In this case, by the cooling of to-be-treated liquid 8, the respective suspended particles are cooled in their entireties. When the portion 2a of this to-be-treated liquid 8 is irradiated with the laser light, the laser light is absorbed at the surfaces of the suspended particles at portion 2a. Since to-be-treated liquid 8 is cooled during this process, significant temperature differences arise between the interiors and surfaces of the suspended particles and between the surfaces of the suspended particles and the to-be-treated liquid at laser light irradiation portion 2a, and highly efficient nanoparticulation is realized.

Abstract: The present invention relates to a fluorescence measuring apparatus having a structure enabling fluorescence measurement of a microvolume sample to be made readily in a short time. The fluorescence measuring apparatus comprises a pumping light source, a pipette device, a tip, attached to the pipette device, and a fluorescence detection system. The pipette device is arranged from a pipette and a pipette adapter having a pumping light introducing structure for introducing pumping light into an internal space, and a fluorescent sample taken in from a suction inlet is held at a front end of the tip. The pumping light from the pumping light source is irradiated onto the fluorescent sample at the front end of the tip via the internal space of the pipette adapter by means of the pumping light introducing structure, and fluorescence is emitted from the fluorescent sample. The fluorescence detection system receives at least a part of the fluorescence generated as a result of this pumping light irradiation.

Abstract: A to-be-treated body, which contains raw material particles 5 of a substance and with which a solvent 4 of a to-be-treated liquid 2 is made solid, is used, and a laser light source 10, which supplies a laser light of a predetermined wavelength to a treatment chamber 3 that contains the to-be-treated body, is provided to arrange a production apparatus 1A. The laser light from the laser light source 10 is illuminated onto the to-be-treated body to microparticulate the substance in solvent 4. As the to-be-treated body of solid form, a solidified body 6, with which water 4 is solidified by a cooling device 50 and the solidified state is maintained by a thermally insulating layer 30, may be used. Or, as the to-be-treated body, a gel body, with which the solvent is gelled, may be used. The substance can thereby microparticulated efficiently by photo-pulverization.

Abstract: A production apparatus 1A includes: a treatment chamber 3, containing a to-be-treated liquid 2, made up of water 4, which is a solvent, and raw material particles 5 of a substance; a laser light source 10, illuminating laser light for microparticulation onto the to-be-treated liquid 2; an ultrasonic transducer 20, irradiating ultrasonic waves for preventing aggregation of microparticles; and a controlling device 15, controlling the laser light illumination by the laser light source 10 and the ultrasonic wave irradiation by the ultrasonic transducer 20. A vibration amplitude of the treatment chamber 3 is monitored by means of a microphone 30 and a vibration amplitude measuring device 35 to set the frequency of the ultrasonic waves to a resonance vibration frequency. A microparticle production method and production apparatus that enable substances to be microparticulated efficiently by photo-pulverization, and microparticles are thereby realized.