Abstract: The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human interleukin-5 receptor ? chain and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

Abstract: A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through ?-bond in a complex N-glycoside-linked sugar chain than its parent cell, and a process for producing an antibody composition using the cell.

Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Abstract: A process for producing an antibody composition using a cell, which comprises using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through &agr;-bond in a complex N-glycoside-linked sugar chain, and a cell used for the process.

Abstract: A cell in which the activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body is more decreased or deleted than its parent cell; a process for producing an antibody composition using the cell; a transgenic non-human animal or plant or the progenies thereof, in which genome is modified so as to have a decreased or deleted activity of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body; a process for producing an antibody composition from the animal or plant; and a medicament comprising the antibody composition.

Abstract: A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through &agr;-bond in a complex N-glycoside-linked sugar chain than its parent cell, and a process for producing an antibody composition using the cell.

Abstract: The present invention provides an antibody composition which specifically binds to CD20 and comprises an antibody molecule which has complex N-glycoside-linked sugar chains bound to the Fc region; a process for producing the antibody composition; and a medicament comprising the antibody composition.

Abstract: The present invention provides a physiologically active peptide, a DNA encoding the peptide, an antibody which recognizes the peptide, and application methods thereof useful in screening and developing a therapeutic agent for diseases which accompany infection and inflammation, diseases which accompany abnormal differentiation and proliferation of smooth muscle cells, diseases which accompany abnormal activation of fibroblasts, diseases which accompany abnormal activation of a synovial tissue, diseases which accompany disorder of pancreatic &bgr; cells, diseases which accompany abnormality of osteoblasts or osteoclasts, diseases which accompany abnormal activation of immunocytes, diseases which accompany disorder of a blood vessel, diseases of an eye based on angiogenesis, diseases which accompany neopla, diseases in which linkage to gene regions of a major histocompatibility antigen is confirmed, and the like.

Abstract: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.

Abstract: The present invention provides a water dispersed resin composition for flocking that is capable of flocking piles on polyolefin substrates without performing a primer treatment. The water dispersed resin composition has been improved in at least one property selected from the coatability of the resin composition, the adhesion between a coating formed therefrom and a substrate, the abrasion resistance of a flocked film formed therewith and the pile retention of the coating. The water dispersed resin composition for flocking comprises a resin composition comprising a copolymer obtained by polymerizing a monomer mixture comprising: component (A): CH2═C(R1)—COO—R2, wherein R1 is a hydrogen atom or a methyl group, R2 is a monocyclic alkyl group; and other unsaturated monomers; and component (B): a resin composition of chlorinated polyolefin.

Abstract: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Abstract: A cordless automatic answering telephone set includes a base station that guides terminal-designation-call codes of the base station and a mobile station associated with the base station, and each of base station and the mobile station can send outgoing messages and record incoming messages. The cordless automatic answering telephone is superior in that the privacy of the user of each of the base and mobile stations can be protected, and the user of each of the base and mobile stations can utilize a selective response function for making a response only to a special person who knows the control signal.

Abstract: A mulcher having a roll of film, a ridger for making a planting ridge to be covered by the film, means for keeping the film taut over the ridge while soil is placed on the film edges, and the film roll is rollably supported to insure dispensing of the film from a fixed position throughout the mulching.

Abstract: A mirror and shutter rebound preventing mechanism in a lens shutter type single-lens reflex camera having a shutter release lever for preliminarily closing a shutter. A shutter blade release ring with a release ring pin follows the shutter release lever and a shutter rebound prevention lever follows the release ring pin. A mirror lifting plate includes pins to drive the two levers. The mirror lifting plate drives the shutter release lever and shutter bound preventing lever before a mirror is lifted. The mirror lifting plate has a protrusion which holds the mirror when the mirror is lowered.

Abstract: A film stop position adjusting mechanism with a stop lever (3) having a stop pawl (3a) engaged with a ratchet gear (2) and adapted to stop the feeding of a film. A ratchet releasing lever (7) holds the stop lever (3) at a release position, with the ratchet releasing lever having a bent portion (7a) and an extended portion (7b). A locking lever (11) has a step (11a) which engages the bent portion (7a) of the ratchet releasing lever to lock the ratchet releasing lever (7). A detection lever has a protrusion (15a) which is inserted into a perforation of the film to detect a film stop position, and an arm (15b) having a straight edge substantially perpendicular to a film feeding direction. The locking lever (11) is provided with an eccentric pin (10) whose position can be adjusted by rotation. The eccentric pin (10) is engaged with an arm (15b) of the detection lever adapted to detect a film stop position by inserting the protrusion (15a) into a film perforation.

Abstract: A metallized plastic molded product is provided which comprises a plastic substrate, a base coat layer, a dry metallic film layer, an inter coat layer and a top coat layer, characterized in that said inter coat layer is a cured ultraviolet curing composition comprising 5-80% by weight of a resin containing 5-50% by weight of repeating unit represented by the formula I: ##STR1## wherein R.sub.1 is H or CH.sub.3, R.sub.2 is H or C.sub.1-8 alkyl, and R.sub.3 is C.sub.1-8 alkyl, and having a molecular weight of 4,000-200,000 and 20-95% by weight of a compound having polymerizable unsaturated groups and said top coat layer is a cured ultraviolet curing composition comprising 40-90% by weight of a urethane modified polyvinyl compound and 10-60% by weight of a polyvinyl compound having a molecular weight of 170-1,000 and having at least two polymerizable unsaturated groups in one molecule. A method for producing the product is also provided.