Patents by Inventor Mitsuru Kataoka
Mitsuru Kataoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240161925Abstract: A learning device 1X mainly includes a first acquisition means 31X, a second acquisition means 32X, and a learning means 34X. The first acquisition means 31X acquires a partial waveform of electrocardiogram data regarding an electrocardiogram of a subject. The second acquisition means 32X acquires an attention interval, which is used as a basis for a diagnosis of a target disease, in a sequential waveform of the electrocardiogram data. The learning means 34X trains a model configured to diagnose the target disease, based on the partial waveform and the attention interval.Type: ApplicationFiled: October 3, 2023Publication date: May 16, 2024Applicant: NEC CorporationInventors: Yuan LUO, Mitsuru NOMA, Osamu HISAMATSU, Kosuke NISHIHARA, Masahiro KUBO, Hiroaki KATAOKA, Akihiko SHIBANO
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Patent number: 5580893Abstract: Nitroxyalkylamide compounds having the formula: R.sup.1 --(A).sub.n --CONH--B'--ONO.sub.2 wherein R.sup.1 is an optionally substituted furyl, furyloxy, thienyl, thienyloxy, isoxazolyl, phenoxy, phenylthio or 1,4-dibenzodioxanyl, A is a C.sub.1 -C.sub.4 alkylene group; B' is a C.sub.1 -C.sub.4 alkylene group; and n is 0 or 1. The compounds of the present invention have a desirable vasodilator action for collateral vessels and an anti-anginal action, and are useful as therapeutic agents for treating angina pectoris.Type: GrantFiled: July 25, 1994Date of Patent: December 3, 1996Assignee: Sankyo Company, LimitedInventors: Sadao Ishihara, Fujio Saito, Mitsuru Kataoka, Hiroyuki Koike, Shigeki Miyake, Hiroshi Mizuno
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Patent number: 5378689Abstract: Compounds of formula (I): ##STR1## [in which: R.sup.1 is heterocyclic group having 5 or 6 ring atoms, or --NR.sup.7 R.sup.8, where R.sup.7 is alkyl and R.sup.8 is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R.sup.2 is optionally substituted phenyl or naphthyl; R.sup.3 is thiazolyl; R.sup.4 is cyclohexyl or isopropyl; R.sup.5 is alkyl; and R.sup.6 is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof.Type: GrantFiled: July 28, 1993Date of Patent: January 3, 1995Assignee: Sankyo Company, LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Yuichiro Yabe, Hiroyuki Koike, Hidekuni Takahagi, Yasuteru Iijima, Tatsuo Kokubu, Kunio Hiwada
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Patent number: 5378690Abstract: Oligopeptides of formula (I): ##STR1## where R.sup.1 -R.sup.5 are various organic groups, and A represents a group of formula --NH-- or --(CH.sub.2).sub.n --, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.Type: GrantFiled: July 30, 1993Date of Patent: January 3, 1995Assignee: Sankyo Company, LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Yuichiro Yabe, Yasuteru Iijima, Hidekuni Takahagi, Hiroyuki Koike, Tatsuo Kokubu, Kunio Hiwada
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Patent number: 5364844Abstract: Compounds of formula (I): ##STR1## A is a carbon-carbon bond or C.sub.1 -C.sub.3 alkylene; B is imino group or C.sub.1 -C.sub.2 alkylene; R.sup.1 is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, heterocyclic or optionally substituted amino; R.sup.2 is optionally substituted phenyl or optionally substituted naphthyl; R.sup.3 is thiazolyl, isoxazolyl or imidazolyl; R.sup.4 is isopropyl or cyclohexyl; R.sup.5 and R.sup.6 are C.sub.1 -C.sub.4 alkyl, or, together with the carbon atom to which they are attached, C.sub.3 -C.sub.7 cycloalkyl; R.sup.7 is hydrogen, optionally substituted C.sub.1 -C.sub.6 alkyl group; and R.sup.8 is hydrogen or C.sub.1 -C.sub.4 alkyl. These compounds have renin-inhibitory and, hence, hypotensive activities. The invention also provides a method for the treatment or prophylaxis of hypertension induced by failures in the renin-angiotensin system.Type: GrantFiled: August 27, 1992Date of Patent: November 15, 1994Assignee: Sankyo Company, LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Yuichiro Yabe, Hiroyuki Koike, Yasuteru Iijima, Hidekuni Takahagi, Tatsuo Kokubu, Kunio Hiwada
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Patent number: 5273976Abstract: Pharmaceutical compositions and methods for treatment of eye disorders employ ocular hypotensive compounds of the formula (I) ##STR1## wherein R.sup.1 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy; each R.sup.2 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro or carboxy; R.sup.3 is selected from amino, mono-substituted amino, and di-substituted amino; A and B each represents C.sub.1 -C.sub.6 alkylene, X represents --NH-- or --CH.sub.2 -- and n is 1, 2 or 3; and pharmaceutically acceptable salts or esters thereof.Type: GrantFiled: October 22, 1992Date of Patent: December 28, 1993Assignee: Sankyo Company, LimitedInventors: Tomihisa Yokoyama, Masaharu Fukami, Mitsuru Kataoka
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Patent number: 5175161Abstract: Pharmaceutical compositions and methods for treatment of eye disorders employ ocular hypotensive compounds of the formula (I); ##STR1## (wherein: R.sup.1 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;each R.sup.2 is selected from hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro or carboxy;R.sup.3 is selected from heterocyclic, amino, mono-substituted amino, and di-substituted amino,A and B each represents C.sub.1 -C.sub.6 alkylene,X represents --NH-- or --CH.sub.2 --; and n is 1, 2 or 3)or pharmaceutically acceptable salts or esters thereof.Type: GrantFiled: April 3, 1990Date of Patent: December 29, 1992Assignee: Sankyo Company, LimitedInventors: Tomihisa Yokoyama, Masaharu Fukami, Mitsuru Kataoka
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Patent number: 4914093Abstract: Compounds of formula (I): ##STR1## (wherein Q is oxygen or sulfur, the dotted line is a single or double bond, A is alkylene, and R.sup.1 -R.sup.5 are a variety of atoms or organic groups)have excellent ability to potentiate myocardial contractivity and a variety of other properties, and can be used to treat cardiac disorders.Type: GrantFiled: March 16, 1989Date of Patent: April 3, 1990Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Seiji Kumakura, Hiroyuki Koike, Shinsaku Kobayashi
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Patent number: 4898862Abstract: Compounds of formula (I): ##STR1## (in which: R.sup.1 is hydrogen or alkl; R.sup.2 is a variety of groups or atoms; R.sup.3 is optionally substituted hydroxy or --(NH).sub.n --NR.sup.5 R.sup.6, wherein R.sup.5 and R.sup.6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C.sub.1 -C.sub.6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group --QH at the 1-position and a group --CO--CHR.sup.1 --NH--COOR.sup.7 at the 4-position by ring closure and introduction of the group of formula --A--CO--R.sup.3 in any order.Type: GrantFiled: March 16, 1987Date of Patent: February 6, 1990Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Mitsuo Sugiyama, Fujio Saito, Hiroyuki Koike, Takeshi Oshima, Yasuo Simoji, Hitoshi Nagahori
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Patent number: 4660852Abstract: A crash energy absorber mounted on the tip end of steering wheel including a structure including a top plate and a pair of side plates extending substantially perpendicularly to the top plate at the opposite sides of the top plate to define a substantially rectangular space with the top plate, and at least one reinforcement extending diagonally in the space defined by the plate structure. The crash energy absorber absorbs a crash energy applied thereto in any direction so as to relieve crash shock from a driver.Type: GrantFiled: September 3, 1985Date of Patent: April 28, 1987Assignee: Mazda Motor CorporationInventors: Kazuo Katayama, Katumi Ooishi, Toshiake Ogawa, Masaru Batai, Mitsuru Kataoka
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Patent number: 4487781Abstract: 1,1,2-Triiodo-1-propene and 1-bromo-1,2-diiodo-1-propene derivatives having a formyloxy, alkanoyloxy, alkoxycarbonyloxy, alkoxycarbonylalkoxy, phenoxycarbonylalkoxy or benzyloxycarbonylalkoxy group at the 3-position are valuable anti-fungal and preservative agents having good heat and light stability.Type: GrantFiled: August 23, 1982Date of Patent: December 11, 1984Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Kiyoshi Konishi, Mitsuru Kataoka
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Method of preserving organic materials from fungal attack and a composition for use in such a method
Patent number: 4421766Abstract: A variety of organic materials susceptible to fungal attack (especially wood and wood-based materials) can be protected from such attack and fungi growing on such materials can be eradicated by treating them, e.g. by applying to the surfaces or impregnating, with one or more compounds of formula (I): ##STR1## (wherein X represents a halogen atom and R represents a hydroxy group, an alkoxy gorup, a substituted or unsubstituted phenoxy group, an amino group, a mono- or di- alkylamino group, a phenylamino or benzylamino group which is unsubstituted or has one or two substituents on the benzene ring of the phenyl or benzyl moiety, or a 3-halo-2,3-diiodoallyloxy group). An anti-fungal composition contains one or more of these compounds in admixture with a carrier or adjuvant.Type: GrantFiled: January 8, 1982Date of Patent: December 20, 1983Assignee: Sankyo Co., Ltd.Inventors: Yasuhiro Morisawa, Kiyoshi Konishi, Mitsuru Kataoka -
Patent number: 4259350Abstract: Iodopropargyl derivatives of formula:IC.tbd.CCH.sub.2 OR[wherein R represents an alkanoyl group (which may be unsubstituted or have one or more halogen, cyano, substituted or unsubstituted .alpha.Type: GrantFiled: March 13, 1979Date of Patent: March 31, 1981Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Kiyoshi Konishi, Mitsuru Kataoka
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Patent number: 4098893Abstract: Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms.Type: GrantFiled: July 15, 1977Date of Patent: July 4, 1978Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Noritoshi Kitano, Toshiaki Matsuzawa
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Patent number: 4094982Abstract: Pyridine derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen atom, amino group or a group ##STR2## in which R.sub.5 and R.sub.6 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms or R.sub.5 is hydrogen atom and R.sub.6 represents an alkyl group of 1 to 4 carbon atoms, an alkenyl group of 3 or 4 carbon atoms or a benzyl group optionally substituted with halogen, cyano, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms;R.sub.2 represents nitro group, amino group or an alkylamino group of 1 to 3 carbon atoms;R.sub.3 and R.sub.Type: GrantFiled: April 28, 1976Date of Patent: June 13, 1978Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Noritoshi Kitano, Toshiaki Mastuzawa
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Patent number: 4054663Abstract: Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms.Type: GrantFiled: December 11, 1975Date of Patent: October 18, 1977Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Noritoshi Kitano, Toshiaki Matsuzawa
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Patent number: 4053608Abstract: Anticoccidial compositions which comprise as active ingredient pyridine derivatives having the formula ##STR1## wherein R.sub.1 is hydrogen atom, a halomethyl group or methyl group;R.sub.2 is hydrogen atom or an alkyl group of 1-3 carbon atoms;R.sub.3 is hydrogen atom, an alkyl group of 1-3 carbon atoms, allyl group, an alkyl group having 2 or 3 carbon atoms and alkoxy of 1 or 2 carbon atoms as a substituent, an alkyl group having 1-3 carbon atoms and hydroxy as a substituent, an alkanoyl group of 1-18 carbon atoms, a haloacetyl group, an alkenoyl group of 3-11 carbon atoms, an aromatic acyl group, a heterocyclic acyl group, an N-alkylcarbamoyl group of 1-4 carbon atoms in the alkyl moiety or hydroxy group;Provided that when R.sub.2 is said alkyl group of 1-3 carbon atoms, R.sub.3 is said alkyl group of 1-3 carbon atoms and inorganic acid addition salts thereof.Type: GrantFiled: August 7, 1975Date of Patent: October 11, 1977Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Noritoshi Kitano, Toshiaki Matsuzawa
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Patent number: 3983238Abstract: An anticoccidial composition which comprises a compound of the formula ##SPC1##Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 are each hydrogen, an aliphatic acyl group, an aromatic acyl group or a heterocyclic acyl group, and at least R.sub.1 and R.sub.2 is said heterocyclic acyl group; or a salt thereof.The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina.The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.Type: GrantFiled: March 12, 1975Date of Patent: September 28, 1976Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Taiichiro Watanabe, Noritoshi Kitano, Toshiaki Matsuzawa
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Patent number: 3935311Abstract: A composition which comprises a pyridinol derivative of the formula ##SPC1##Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 may be the same or different and each represents a hydrogen atom; a lower alkyl group, an aralkyl group, an aliphatic, an aromatic or a heterocyclic acyl group; an alkoxycarbonyl group; an aralkoxycarbonyl group; an aryloxycarbonyl group; a N-substituted carbonyl group; a N-substituted thiocarbonyl group; a phosphono group; or a salt thereof.The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina.The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.Type: GrantFiled: September 26, 1974Date of Patent: January 27, 1976Assignee: Sankyo Company LimitedInventors: Yasuhiro Morisawa, Mitsuru Kataoka, Taiichiro Watanabe, Noritoshi Kitano, Toshiaki Matsuzawa