Patents by Inventor Mitsuru Shiraishi
Mitsuru Shiraishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20060100197Abstract: The present invention provides a compound represented by the formula: wherein R1 is a 5- or 6-membered ring which may be substituted; R3 is a hydrogen atom, a lower alkyl group or a lower alkoxy group; Z1 is a 5- or 6-membered aromatic ring; Z2 is a group represented by -Z2a-W2-Z2b wherein Z2a and Z2b are each O, S(O)m (wherein m is 0, 1 or 2), an imino group, or a bond; and W2 is an alkylene chain which may be substituted; n is an integer of 0 to 4; Y is O, S(O)p (wherein p is 0, 1 or 2), CH2 or NR4 (wherein R4 is a hydrogen atom, a hydrocarbon group, a heterocyclic group, or an acyl group); and R2 is (1) an amino group, in which the nitrogen atom is converted to quaternary ammonium or oxide, (2) a nitrogen-containing heterocyclic group which may contain a sulfur atom or an oxygen atom as a ring-constituting atom, in which the nitrogen atom may be converted to a quaternary ammonium or an oxide, and the like, or a salt thereof.Type: ApplicationFiled: February 5, 2004Publication date: May 11, 2006Applicant: Takeda Pharmaceutical Company LimitedInventors: Mitsuru Shiraishi, Katsuji Aikawa, Naoyuki Kanzaki, Masanori Baba
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Publication number: 20050245537Abstract: It is intended to provide preventives/remedies for graft-versus-host disease and/or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis. The above object can be achieved by preventives/remedies for graft-versus-host disease and/or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis characterized by containing a specific compound having a CCR (CC chemokine receptor) antagonism.Type: ApplicationFiled: April 23, 2003Publication date: November 3, 2005Inventors: Noboru Tsuchimori, Yuji Iizawa, Mitsuru Shiraishi, Yoshihiro Sugihara
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Patent number: 6936602Abstract: Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally Substituted hetero-alicyclic group.Type: GrantFiled: June 15, 2000Date of Patent: August 30, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Yoshio Aramaki, Naoyuki Kanzaki, Osamu Nishimura
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Publication number: 20050154016Abstract: It is intended to provide a novel drug which exhibits an excellent effect of preventing HIV infection in transfusing blood and using a blood preparation. This object can be achieved by a preventive for HIV infection in transfusing blood and using a blood prepartion characterized by containing a compound having an antagonism to a CC chemokine receptor (preferably antagonism to CCR5 and/or CCR2).Type: ApplicationFiled: April 17, 2003Publication date: July 14, 2005Inventors: Katsunori Takashima, Yuji Iizawa, Mitsuru Shiraishi, Yoshihiro Sugihara, Masanori Baba
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Publication number: 20040259876Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof.Type: ApplicationFiled: January 23, 2004Publication date: December 23, 2004Inventors: Mitsuru Shiraishi, Masanori Baba, Katsuji Aikawa, Naoyuki Kanzaki, Masaki Seto, Yuji Iizawa
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Publication number: 20040235822Abstract: The present invention provides a novel benzazepine derivative represented by formula: 1Type: ApplicationFiled: February 5, 2004Publication date: November 25, 2004Inventors: Mitsuru Shiraishi, Masanori Baba, Masaki Seto, Yoshio Aramaki, Naoyuki Kanzaki, Naoki Miyamoto, Yuji Iizawa
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Patent number: 6706732Abstract: A nasal preparation comprising a compound represented by the formula: wherein Ring A is an optionally substituted 5- or 6-membered aromatic heterocyclic ring, Ring B is an optionally substituted 5- or 6-membered aromatic homocyclic or heterocyclic ring, R1 is a hydrogen atom, a hydroxyl group or a lower alkyl group, and n is 0 or 1, which has an Na—H exchange inhibiting activity, or a salt thereof exhibits excellent bioabsorbability and an Na—H exchange inhibiting activity superior to that of an oral preparation, thus being useful as a prophylactic and/or therapeutic agent for ischemic heart diseases such as myocardial infarct and arrhythmia.Type: GrantFiled: November 28, 2001Date of Patent: March 16, 2004Assignee: Takeda Chemical Industries, Ltd.Inventors: Masafumi Misaki, Shigeyuki Takada, Mitsuru Shiraishi, Shoji Fukumoto
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Patent number: 6655244Abstract: A centering apparatus for centering a disk about a center member such as a shaft or hub includes a plurality of pairs of actuator units. The actuator units of each of the pairs faces each other through the disk. Each of the actuator units has a member which moves linearly and can come into contact with the disk.Type: GrantFiled: June 18, 1999Date of Patent: December 2, 2003Assignee: Fujitsu LimitedInventors: Mitsuru Shiraishi, Koichi Oikawa, Hitoshi Komoriya, Yutaka Nakamura, Takao Hirahara
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Patent number: 6627651Abstract: Compounds of general formula (1) R1—X1—W—X2—Z1—Z2—R2 or salts thereof, exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1 is an optionally substituted five- or six-membered ring group; X1 is a free valency or the like; W is a divalent group represented by, e. g., general formula (2) (wherein A and B are each an optionally substituted five- to seven-membered ring; E1 and E4 are each optionally substituted carbon or the like; E2 and E3 are each oxygen or the like; and a and b are each a single bond or a double bond); X2 is a divalent group constituting a straight chain moiety; Z1 is a divalent cyclic group or the like; Z2 is a free valency or the like; and R2 is optionally substituted amino or the like.Type: GrantFiled: November 2, 2001Date of Patent: September 30, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Masaki Seto, Naoyuki Kanzaki, Osamu Nishimura
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Patent number: 6413947Abstract: This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an, optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.Type: GrantFiled: September 13, 2000Date of Patent: July 2, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Takahito Kitayoshi, Yoshio Aramaki, Susumu Honda, Tsuneo Oda
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Patent number: 6376536Abstract: This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is —CH2—, —S— or —O—; and R2, R3 and R4 are independently an optionally substituted aliphatic hydrocarbon group or an optionally substituted alicyclic heterocyclic ring group, and being effective for the prevention and treatment of infectious disease of HIV.Type: GrantFiled: May 26, 2000Date of Patent: April 23, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Yoshio Aramaki, Osamu Nishimura, Naoyuki Kanzaki
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Publication number: 20020029667Abstract: A centering apparatus for centering a disk about a center member such as a shaft or hub includes a plurality of pairs of actuator units. The actuator units of each of the pairs faces each other through the disk. Each of the actuator units has a member which moves linearly and can come into contact with the disk.Type: ApplicationFiled: June 18, 1999Publication date: March 14, 2002Inventors: MITSURU SHIRAISHI, KOICHI OIKAWA, HITOSHI KOMORIYA, YUTAKA NAKAMURA, TAKAO HIRAHARA
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Patent number: 6350749Abstract: The present invention is to provide a compound of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optionally substituted 5- to 6-membered aromatic heterocyclic ring, R1 is a hydrogen atom, a hydroxy group or a lower alkyl group, and n is 0 or 1, or a salt thereof, which is effective for the prevention or treatment of ischemic cardiac disease, etc., and which is useful as an agent for preventing or treating ischemic cardiac disease, etc. such as myocardial infarction, arrhythmia, etc.Type: GrantFiled: August 8, 2000Date of Patent: February 26, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Shoji Fukumoto, Keiji Kusumoto
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Patent number: 6276149Abstract: In an air conditioner having a refrigerant circuit in which a compressor, a four-way switching valve, an outdoor-side heat exchanger, an expansion valve, and an indoor-side heat exchanger are connected in succession via pipes, the interior of an enclosed vessel of a compressor, which contains a refrigerant compressing section and an electric motor, is divided airtightly into a refrigerant discharge chamber and an electric motor chamber, two refrigerant flow path pipes are provided on the electric motor chamber side, and these refrigerant flow path pipes are appropriately switched to the refrigerant discharge side and the refrigerant suction side of the compressor via the four-way switching valve, whereby one compressor can be used as an internal high pressure type or an internal low pressure type.Type: GrantFiled: January 24, 2001Date of Patent: August 21, 2001Assignee: Fujitsu General LimitedInventors: Masashi Katayama, Makoto Araki, Masaki Fujino, Jyunya Tanaka, Motonobu Furukawa, Akira Shimada, Shuji Takeda, Hiroki Tomoda, Mitsuru Shiraishi, Keiichi Nakamura, Takefumi Inagaki
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Patent number: 6268354Abstract: This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof.Type: GrantFiled: September 13, 2000Date of Patent: July 31, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Osamu Nishimura, Masanori Baba, Hidekazu Sawada, Naoyuki Kanzaki, Ken-ichi Kuroshima, Mitsuru Shiraishi, Yoshio Aramaki
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Publication number: 20010001923Abstract: In an air conditioner having a refrigerant circuit in which a compressor, a four-way switching valve, an outdoor-side heat exchanger, an expansion valve, and an indoor-side heat exchanger are connected in succession via pipes, the interior of an enclosed vessel of a compressor, which contains a refrigerant compressing section and an electric motor, is divided airtightly into a refrigerant discharge chamber and an electric motor chamber, two refrigerant flow path pipes are provided on the electric motor chamber side, and these refrigerant flow path pipes are appropriately switched to the refrigerant discharge side and the refrigerant suction side of the compressor via the four-way switching valve, whereby one compressor can be used as an internal high pressure type or an internal low pressure type.Type: ApplicationFiled: January 24, 2001Publication date: May 31, 2001Inventors: Masashi Katayama, Makoto Araki, Masaki Fujino, Jyunya Tanaka, Motonobu Furukawa, Akira Shimada, Shuji Takeda, Hiroki Tomoda, Mitsuru Shiraishi, Keiichi Nakamura, Takefumi Inagaki
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Patent number: 6235771Abstract: This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5 and R6 are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5 and R6 may bind to each other to form a cyType: GrantFiled: March 27, 2000Date of Patent: May 22, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Masanori Baba, Masaki Seto, Naoyuki Kanzaki, Osamu Nishimura
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Patent number: 6202428Abstract: In an air conditioner having a refrigerant circuit in which a compressor, a four-way switching valve, an outdoor-side heat exchanger, an expansion valve, and an indoor-side heat exchanger are connected in succession via pipes, the interior of an enclosed vessel of a compressor, which contains a refrigerant compressing section and an electric motor, is divided airtightly into a refrigerant discharge chamber and an electric motor chamber, two refrigerant flow path pipes are provided on the electric motor chamber side, and these refrigerant flow path pipes are appropriately switched to the refrigerant discharge side and the refrigerant suction side of the compressor via the four-way switching valve, whereby one compressor can be used as an internal high pressure type or an internal low pressure type.Type: GrantFiled: September 13, 1999Date of Patent: March 20, 2001Assignee: Fujitsu General LimitedInventors: Masashi Katayama, Makoto Araki, Masaki Fujino, Jyunya Tanaka, Motonobu Furukawa, Akira Shimada, Shuji Takeda, Hiroki Tomoda, Mitsuru Shiraishi, Keiichi Nakamura, Takefumi Inagaki
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Patent number: 6172061Abstract: This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof.Type: GrantFiled: December 17, 1998Date of Patent: January 9, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Osamu Nishimura, Masanori Baba, Hidekazu Sawada, Naoyuki Kanzaki, Ken-ichi Kuroshima, Mitsuru Shiraishi, Yoshio Aramaki
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Patent number: 6166006Abstract: This invention is to provide a compound of the formula: ##STR1## wherein R.sup.1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R.sup.2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.Type: GrantFiled: December 17, 1998Date of Patent: December 26, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuru Shiraishi, Takahito Kitayoshi, Yoshio Aramaki, Susumu Honda, Tsuneo Oda