Patents by Inventor Miwako Asanuma

Miwako Asanuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for analyzing biomolecules using Raman spectroscopy
    Patent number: 10338078
    Abstract: The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: July 2, 2019
    Assignee: Japan Science and Technology Agency
    Inventors: Mikiko Sodeoka, Jun Ando, Miwako Asanuma, Kosuke Dodo, Katsumasa Fujita
  • Method and Apparatus for Analyzing Biomolecules Using Raman Spectroscopy
    Publication number: 20150192590
    Abstract: The present invention provides an apparatus having a sample separation unit, a Raman spectroscopy unit, and a mass spectrometry unit. The present invention further provides a method for specifying a biomolecule and a method for identifying the binding site of the biomolecule and the low-molecular-weight compound, comprising a combination of Raman spectroscopy and mass spectrometry. The present invention further provides a surface-enhanced Raman spectroscopy method with improved sensitivity.
    Type: Application
    Filed: August 13, 2013
    Publication date: July 9, 2015
    Applicant: Japan Science and Technology Agency
    Inventors: Mikiko SODEOKA, Jun ANDO, Miwako ASANUMA, Kosuke DODO, Katsumasa FUJITA
  • Methods of preparing samples for MALDI mass spectrometry and reagent compositions for the same
    Patent number: 7928367
    Abstract: A simple and efficient method of preparing a sample in the measurement according to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) capable of inhibiting any ion suppression by impurities, such as inorganic salts and surfactants, contained in the sample. An analyte and matrix molecules are co-crystallized in the presence of porous microparticles. Preferably, this co-crystallization is carried out by bringing the analyte, matrix molecules and porous microparticles into contact with each other on a target plate and thereafter drying the mixture. The porous microparticles consist of an ion exchanger having an average particle diameter of not more than 50 ?m, preferably a strongly basic anion exchanger.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: April 19, 2011
    Assignee: Riken
    Inventors: Hiroshi Hirota, Miwako Asanuma, Seketsu Fukuzawa, Shigeyuki Yokoyama
  • METHODS OF PREPARING SAMPLES FOR MALDI MASS SPECTROMETRY AND REAGENT COMPOSITIONS FOR THE SAME
    Publication number: 20080067343
    Abstract: A simple and efficient method of preparing a sample in the measurement according to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) capable of inhibiting any ion suppression by impurities, such as inorganic salts and surfactants, contained in the sample. An analyte and matrix molecules are co-crystallized in the presence of porous microparticles. Preferably, this co-crystallization is carried out by bringing the analyte, matrix molecules and porous microparticles into contact with each other on a target plate and thereafter drying the mixture. The porous microparticles consist of an ion exchanger having an average particle diameter of not more than 50 ?m, preferably a strongly basic anion exchanger.
    Type: Application
    Filed: July 2, 2007
    Publication date: March 20, 2008
    Applicant: RIKEN
    Inventors: Hiroshi HIROTA, Miwako ASANUMA, Seketsu FUKUZAWA, Shigeyuki YOKOYAMA