Abstract: The present disclosure relates to bioactive peptides, compositions, production processes and uses of bioactive peptides based on snake venom as anti-tumoral agents. The disclosed bioactive peptides are synthesized based on the C-terminal of the Crotoxin B and its derivatives. The disclosed peptides demonstrate a lessened toxic effect and an elevated anti-tumoral activity against tumor cells, but specifically against triple-negative breast cancer cells, as compared to current standard care. Therefore, the disclosed bioactive snake venom peptides derived from Crotoxin are for the modulation of cellular proliferation, apoptosis, necrosis and the cycle progression of the tumor cells, especially in the triple negative breast cancer cells, presenting a suitable alternative for the sole or complementary treatment of patients with aggressive solid tumors.

Abstract: Electrostimulation processes and equipment used in the control of pelvic pain of different etiologies, particularly, pain resulting from dysmenorrhea and endometriosis, the process predicting the development of an electrostimulation protocol wherein variation of the intensity of the electric pulses is performed in a random manner to reduce the physiological phenomenon of nerve fiber accommodation upon stimuli. A portable electrostimulation device includes a double bandage formed by two sheets, each including a central portion and two side flaps, a compartment between the central portions housing the electronic module of the apparatus, the side flaps of the top sheet housing the respective electrodes having respective gel layers protected by removable protective sheets which include respective fastening strips.

Abstract: Process and electrostimulation equipment employed in controlling pains of various etiologies, the process predicting the development of an electrostimulation protocol in which the variation of electrical pulses intensity is performed in a random fashion, respecting the limits of stimulation efficiency, in order to reduce the physiological phenomenon of nerve fiber accommodation to the stimuli, the electrostimulation portable equipment, having of a bandage, and having a central electronic module and two lateral flaps, which contain the respective electrodes covered by gel layers removable protective sheets. The module houses the internal components and the electric circuit equipment, power battery, which is a coin-shaped lithium-ion battery. The equipment includes power source, step-up regulator, micro controller, power supply seal, boost source, H-bridge, and electrode output, and switch off module.

Abstract: Process and electrostimulation equipment employed in the control of headaches, said process predicting the development of an electrostimulation protocol in which the variation of electric pulse variation is made in a random manner to reduce the physiological phenomenon of nerve fiber accommodation upon stimuli; portable electrostimulation equipment, formed by an electrostimulation set and support is provided, the former consisting of a cylindrical compartment housing an electric circuit board and disposable coin-shaped lithium-ion battery, model CR20XX, in whose back face there are recesses, which house the respective electrodes, suitably covered by respective gel layers protected by removable protective sheets; the electrostimulation set being engaged with the medial longitudinal groove of the support, which configures the rail along which aid set is moved; the following internal components are also provided: Power source module, step-up regulator module, micro controller module, power supply seal module, bo

Abstract: Process and equipment for muscular performance recovery in patients in general, specifically, ones practicing physical activity and athletes, the process providing the serial application of electrical pulses, transcutaneously, following stimulation steps: vasodilation, recovery and untightening phases. Equipment includes an electronic module containing monolithic cabinet having a body with two halves containing a mounted printed circuit board carrying the electronic circuit and the microcontroller, a power supply having a battery, whose external lower face houses a main electrode, and, with two electric conductor cables with satellite electrodes extending from a distal side, the electrodes having self-adhesive gel plates. An adjustable strip secures the equipment around a user's limb. A control panel has a power button and two intensity selection buttons.

Abstract: The present utility model relates to the assembly arrangement for a bandage holding a portable small-scale transcutaneous electrical nerve stimulator device.

Abstract: The present utility model relates to the assembly arrangement for a bandage holding a portable small-scale transcutaneous electrical nerve stimulator device.