Patents by Inventor Mohamed H. Sayegh

Mohamed H. Sayegh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE ENCODING A MULTIDRUG-RESISTANCE HUMAN P-GLYCOPROTEIN HOMOLOGUE ON CHROMOSOME 7P15-21 AND USES THEREOF
    Publication number: 20090162873
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell s susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Application
    Filed: November 19, 2008
    Publication date: June 25, 2009
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • TARGETING ABCB5 FOR CANCER THERAPY
    Publication number: 20090117117
    Abstract: The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.
    Type: Application
    Filed: April 11, 2008
    Publication date: May 7, 2009
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Natasha Y. Frank, Mohamed H. Sayegh
  • Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-2 and uses thereof
    Patent number: 7465554
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: December 16, 2008
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
    Patent number: 6846883
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: January 25, 2005
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof
    Publication number: 20020037522
    Abstract: The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
    Type: Application
    Filed: June 5, 2001
    Publication date: March 28, 2002
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Markus H. Frank, Mohamed H. Sayegh
  • Treatment of allograft rejection with anti-angiogenic agents
    Publication number: 20010014663
    Abstract: The invention relates a method of inhibiting allograft rejection in a subject with an organ transplant. The method comprises administering an effective amount of one or more anti-angiogenic agents to a subject alone or in combination with one or more immunosuppressive agents. The invention provides new and improved methods of inhibiting allograft rejection.
    Type: Application
    Filed: January 17, 2001
    Publication date: August 16, 2001
    Inventors: David M. Briscoe, Karen Moulton, Mohamed H. Sayegh
  • Treatment of chronic allograft rejection with anti-angiogenic agents
    Patent number: 6218361
    Abstract: The invention relates a method of inhibiting chronic allograft rejection in a subject with an organ transplant. The method comprises administering an effective amount of one or more anti-angiogenic agents to a subject alone or in combination with one or more immunosuppressive agents. The invention provides new and improved methods of inhibiting allograft rejection.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: April 17, 2001
    Assignee: Children's Medical Center Corporation
    Inventors: David M. Briscoe, Karen Moulton, Mohamed H. Sayegh