Patents by Inventor Mohamed M. A. Awad

Mohamed M. A. Awad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide analogs as irreversible interleukin-1beta protease inhibitors
    Publication number: 20040009923
    Abstract: Disclosed are compounds, compositions and methods for inhibiting interleukin-1&bgr; protease activity, the compounds having the formula (I).
    Type: Application
    Filed: January 16, 2003
    Publication date: January 15, 2004
    Inventors: Roland E. Dolle, Irennegbe K. Osifo, Stanley J. Schmidt, Denton W. Hoyer, Tina Morgan Ross, Prasad V. Chaturvedula, Catherine P. Prouty, Mohamed M.A. Awad, Joseph M. Salvino, James M. Rinker, Eric P. Lodge, Jasbir Singh, Mark A. Ator
  • Biaryl compounds useful as anticancer agents
    Patent number: 6576632
    Abstract: The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: June 10, 2003
    Assignee: Pfizer Inc
    Inventors: Steven W. Goldstein, Kelly P. Longo, James F. Blake, Mohamed M. A. Awad, Kenneth P. Raiche, Kevin W. Kramer
  • Peptide analogs as irreversible interleukin-1&bgr; protease inhibitors
    Patent number: 6576614
    Abstract: Disclosed are compounds, compositions, and methods for inhibiting interleukin-1&bgr; protease activity, wherein the compounds are &agr;-substituted methyl ketones having formula (I) as set forth herein. These compounds are inhibitors of IL-1&bgr; converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: June 10, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Roland E. Dolle, Irennegbe K. Osifo, Stanley J. Schmidt, Denton W. Hoyer, Tina Morgan Ross, Prasad V. Chaturvedula, Catherine P. Prouty, Mohamed M. A. Awad, Joseph M. Salvino, James M. Rinker, Eric P. Lodge, Jasbir Singh, Mark A. Ator
  • Peptide analogs as irreversible interleukin-1.beta. protease inhibitors
    Patent number: 5985838
    Abstract: Disclosed are compounds, compositions and methods for inhi.beta.iting interleukin-1.beta. protease activity, the compounds .alpha.-substituted methyl ketones having the formula (I) set forth herein. These compounds are inhibitors of IL-1.beta. converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: November 16, 1999
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Roland E. Dolle, Irennegbe K. Osifo, Stanley J. Schmidt, Denton W. Hoyer, Tina Morgan Ross, Prasad V. Chaturvedula, Catherine P. Prouty, Mohamed M. A. Awad, Joseph M. Salvino, James M. Rinker, Eric P. Lodge, Jasbir Singh, Mark A. Ator
  • .alpha.-heteroaryloxymethyl ketones as interleukin - 1 .beta. converting enzyme inhibitors
    Patent number: 5677283
    Abstract: Compounds which Inhibit interleukin-1.beta. protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1## wherein n is 0-2; each AA is Independently L-valine or L-alanine;R.sub.1 is selected from the group consisting of N-?4(N,N-dimethylaminomethyl)!benzoyl, N-benzoyloxycarbonyl, N-methyl-N-?4-(pyridyl)methyl!, N-?4-(pyddyl)methyl!carbonyl, N-3-(piperidinopropionyl), N-?4-(morpholinoethoxy)benzoyl, N-2-(quinuclidinyl)carbonyl, N-(3-pyridyl)methoxy carbonyl, N-(2-pyddyl)methoxy carbonyl, N-methyl-N-benzyl carbonyl, N-methyl-N-?2-(4-pyridyl)ethyl!carbonyl, and N-(N-phenylpiperazino) carbonyl; andR.sub.8, R.sub.9 and R.sub.10 are as defined below.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: October 14, 1997
    Assignee: Sanofi
    Inventors: Roland E. Dolle, Jasbir Singh, David A. Whipple, Catherine Prouty, Prasad V. Chaturvedula, Stanley J. Schmidt, Mohamed M. A. Awad, Denton W. Hoyer, Tina Morgan Ross
  • Heteroaryloxymethyl ketones as interleukin-1.beta.converting enzyme inhibitors
    Patent number: 5585357
    Abstract: Compounds which inhibit interleukin-1.beta. protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1## wherein n is 0-2; each AA is independently L-valine or L-alanine; R.sub.1 is selected from the group consisting of N-[4-(N,N-dimethylaminomethyl)]benzoyl, N-benzyloxycarbonyl, N-methyl-N-[4-(pyridyl)methyl], N-[4-(pyridyl)methyl]carbonyl, N-3-(piperidinopropionyl), N-[4-(morpholinoethoxy)benzoyl, N-2-(quinuclidinyl)carbonyl, N-(3-pyridyl)methoxy carbonyl, N-(2-pyridyl)methoxy carbonyl, N-methyl-N-benzyl carbonyl, N-methyl-N-[2-(4-pyridyl)ethyl]carbonyl, and N-(N-phenylpiperazino)carbonyl; and R.sub.8, R.sub.9, R.sub.10 are each independently hydrogen, lower alkyl, halo substituted methyl, carbalkoxy, benzyl, phenyl, or phenyl mono or disubstituted with fluoro, nitro, methoxy, chloro, trifluoromethyl or methanesulfonyl.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: December 17, 1996
    Assignee: Sanofi Winthrop Inc.
    Inventors: Roland E. Dolle, Jasbir Singh, David A. Whipple, Catherine Prouty, Prasad V. Chaturvedula, Stanley J. Schmidt, Mohamed M. A. Awad, Denton W. Hoyer, Tina M. Ross
  • Nonpeptide bradykinin antagonists
    Patent number: 5578601
    Abstract: Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof therefor.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: November 26, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Peter R. Seoane, Joseph M. Salvino, Brent D. Douty, Mohamed M. A. Awad, Roland E. Dolle, David G. Sawutz, David M. Faunce, Wayne T. Houck
  • Nonpeptide bradykinin antagonists
    Patent number: 5510380
    Abstract: Disclosed are nonpeptides having bradykinin antagonist activity of the formulae (I) and (II) ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and methods of treating diseased or pathological conditions using the pharmaceutical compositions.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: April 23, 1996
    Assignee: Sterling Winthrop, Inc.
    Inventors: Peter R. Seoane, Joseph M. Salvino, Brent D. Douty, Mohamed M. A. Awad, Roland E. Dolle, David G. Sawutz, David M. Faunce, Wayne T. Houck