Patents by Inventor Mohammad A. Mandegar

Mohammad A. Mandegar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluoroalkyl-oxadiazoles and uses thereof
    Patent number: 11926622
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.
    Type: Grant
    Filed: December 23, 2022
    Date of Patent: March 12, 2024
    Assignee: Tenaya Therapeutics, Inc.
    Inventors: Snahel Patel, Mohammad A. Mandegar, David Sperandio, Julio Medina, Ulhas Bhatt, Alok Nerurkar, Tien Widjaja
  • HDAC6 INHIBITORS FOR TREATMENT OF METABOLIC DISEASE AND HFPEF
    Publication number: 20230381148
    Abstract: Provided herein are methods of treating or preventing metabolic disease with an HDAC6 inhibitor. Also provided herein are methods of treating or preventing heart failure with preserved ejection fraction with an HDAC6 inhibitor. A variety of HDAC6 inhibitors are described herein for use in treating or preventing metabolic disease or heart failure with preserved ejection fraction. In one aspect, described herein are methods of treating a human patient by orally administering an HDAC6 inhibitor, such as an inhibitor of Formula (I) or Formula (II).
    Type: Application
    Filed: July 27, 2023
    Publication date: November 30, 2023
    Inventors: Jin YANG, Mohammad A. MANDEGAR, Timothy C. HOEY
  • FLUOROALKYL-OXADIAZOLES AND USES THEREOF
    Publication number: 20230143804
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.
    Type: Application
    Filed: December 23, 2022
    Publication date: May 11, 2023
    Inventors: Snahel PATEL, Mohammad A. MANDEGAR, David SPERANDIO, Julio MEDINA, Ulhas BHATT, Alok NERUKAR, Tien WIDJAJA
  • 5-FLUORONICOTINAMIDE DERIVATIVES AND USES THEREOF
    Publication number: 20230123856
    Abstract: Provided herein is a compound of Formula (I), or pharmaceutically acceptable salt thereof, wherein R1, Y, X, and n are defined herein. Also provided herein are compositions comprising a compound of Formula (I) or pharmaceutically acceptable salt thereof, and methods of using a compound of Formula (I) or pharmaceutically acceptable salt thereof, e.g., in the treatment of heart disease.
    Type: Application
    Filed: April 4, 2022
    Publication date: April 20, 2023
    Applicant: Tenaya Therapeutics, Inc.
    Inventors: Mohammad A. MANDEGAR, Snahel PATEL, Ulhas BHATT, Pingyu DING, Martin HOLAN, John LEE, Yihong LI, Julio MEDINA, Alok NERURKAR, Frederick SEIDL, David SPERANDIO, Tien WIDJAJA, Xiaodong WANG
  • Fluoroalkyl-oxadiazoles and uses thereof
    Patent number: 11578066
    Abstract: Provided herein are compounds identified as inhibitors of HDAC6 activity having the formula: or a pharmaceutically acceptable salt thereof, that can be used to treat various diseases and disorders.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: February 14, 2023
    Assignee: Tenaya Therapeutics, Inc.
    Inventors: Snahel Patel, Mohammad A. Mandegar, David Sperandio, Julio Medina, Ulhas Bhatt, Alok Nerurkar, Tien Widjaja