Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.

Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.

Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: A variable geometry turbine assembly comprising an inlet passageway, extending radially inwards towards a turbine wheel, defined between a surface of a movable wall member and a facing wall and an actuation mechanism arranged to move the movable wall member axially and comprising a cam member provided with at least one formation and a carrier member axially coupled to at least one co-operating formation, wherein one of the at least one formation and the at least one co-operating formation is a radially extending formation, the at least one formation or the at least one co-operating formation extending in both the circumferential direction and the axial direction such that as the cam member is rotated relative to the carrier member, the at least one formation and the at least one co-operating formation engage such the movable wall member is moved in the axial direction.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: A variable geometry turbine assembly comprising an inlet passageway, extending radially inwards towards a turbine wheel, defined between a surface of a movable wall member and a facing wall and an actuation mechanism arranged to move the movable wall member axially and comprising a cam member provided with at least one formation and a carrier member axially coupled to at least one co-operating formation, wherein one of the at least one formation and the at least one co-operating formation is a radially extending formation, the at least one formation or the at least one co-operating formation extending in both the circumferential direction and the axial direction such that as the cam member is rotated relative to the carrier member, the at least one formation and the at least one co-operating formation engage such the movable wall member is moved in the axial direction.

Abstract: A turbocharger bearing housing defines a bore in which the turbocharger shaft is mounted for rotation in journal bearings. Lubricating oil is delivered to the journal bearings and a residue is retained in reservoirs in which the journal bearings are located. Two fluid retaining members are disposed around the shaft, each forming a wall of the reservoir and being sealed to the bearing housing. The lubricating fluid reservoir is provided between the fluid retaining members to a depth that at least partially immerses the journal bearings even when the oil supply is interrupted. This ensures that there is sufficient oil to lubricate the bearings at engine start-up, thereby reducing the risk of wear.

Abstract: A fail-safe fluid, particularly, water distribution apparatus for use within residential, commercial and industrial buildings comprising (i) a conduit through which fluid is distributed; (ii) a fluid flow time-sensitive sensor cooperative with the conduit to operably detect fluid flow within the conduit over desired periods of time; and (iii) a fluid control valve to control the flow of the fluid within the conduit cooperative with the sensor.

Abstract: A turbocharger bearing housing defines a bore in which the turbocharger shaft is mounted for rotation in journal bearings. Lubricating oil is delivered to the journal bearings and a residue is retained in reservoirs in which the journal bearings are located. Two fluid retaining members are disposed around the shaft, each forming a wall of the reservoir and being sealed to the bearing housing. The lubricating fluid reservoir is provided between the fluid retaining members to a depth that at least partially immerses the journal bearings even when the oil supply is interrupted. This ensures that there is sufficient oil to lubricate the bearings at engine start-up, thereby reducing the risk of wear.