Abstract: The present invention relates to a NDG-Mn3O4 nanocomposite comprising a nitrogen doped graphene (NDG) and Mn3O4 nanoparticles. The NDG-Mn3O4 nanocomposite is useful in bimodal performance including photodynamic therapy (PDT) and magnetic resonance imaging (MRI). The NDG-Mn3O4 nanocomposites of the present invention caused significant cell death under laser irradiation, while control and Mn3O4 nanoparticles showed negligible cell death.

Abstract: The present disclosure provides HRG-Mn3O4 hybrid nanoparticles. The HRG-Mn3O4 hybrid nanoparticles do not pose any cytotoxicity at normal physiological conditions and therefore they are nontoxic and biocompatible at physiological conditions. The HRG-Mn3O4 hybrid nanoparticles under exposure of laser light cause massive cellular damage indicating their potential use for photodynamic therapy of cancer. The HRG-Mn3O4 hybrid nanoparticles enhance the magnetic resonance signals from cancer cells and exhibit excellent MRI contrast property for tumor imaging and are therefore useful contrast agent.

Abstract: The subject matter of this specification can be implemented in, among other things, a method that includes pre-registering, at a client device, one or more input/output (IO) buffers for a remote direct memory access (RDMA) interface at the client device. In response to pre-registering the one or more IO buffers at the client device, an application executed by the client device is provided with access to a distributed file system through the RDMA interface. In response to determining that data of a requested file in the distributed file system has been designated for caching, a first IO buffer among the IO buffers is designated as a cache for the data of the file. The data for the file is received via the RDMA interface and from the distributed file system, for the first IO buffer.

Abstract: The subject matter of this specification can be implemented in, among other things, a method that includes pre-registering multiple memory regions for input/output (IO) buffers of a remote direct memory access (RDMA) interface. The method includes receiving a buffer reservation request from a non-system-based user (NSBU) application through an application programming interface (API). The method includes reserving for the NSBU application a first IO buffer. The method includes receiving a request from the NSBU application through the API to access a file in a distributed file system. The method includes receiving data for the file in the first IO buffer from the distributed file system using the RDMA interface or providing data for the file from the first IO buffer to the distributed file system using the RDMA interface. The method includes receiving a request from the NSBU application through the API to free the first IO buffer.

Abstract: The subject matter of this specification can be implemented in, among other things, a method that includes pre-registering, at a client device, one or more input/output (IO) buffers for a remote direct memory access (RDMA) interface at the client device. In response to pre-registering the one or more IO buffers at the client device, an application executed by the client device is provided with access to a distributed file system through the RDMA interface. In response to determining that data of a requested file in the distributed file system has been designated for caching, a first IO buffer among the IO buffers is designated as a cache for the data of the file. The data for the file is received via the RDMA interface and from the distributed file system, for the first IO buffer.

Abstract: The subject matter of this specification can be implemented in, among other things, a method that includes pre-registering, by a processing device at a client device, multiple input/output (IO) buffers at the client device with a remote direct memory access (RDMA) interface at the client device. The client device accesses multiple server devices of a distributed file system using the RDMA interface. The method further includes receiving a request to access a file in the distributed file system from an application at the client device. The method further includes designating a first IO buffer among the IO buffers as a cache for data from the file. The method further includes receiving the data for the file in the first IO buffer from the distributed file system using the RDMA interface.

Abstract: A fuel delivery system for an engine is provided. The fuel delivery system includes a fuel rail, a pressure sensor, a relief valve, and a controller. The controller is configured to receive a signal indicative of a fuel rail pressure, identify exceeding of the fuel rail pressure beyond a first threshold, identify the fuel rail pressure drop below a second threshold, and initiate a counter for a first predefined amount of time accordingly. The controller is also configured to identify if the fuel rail pressure drops below a third threshold within the first predefined amount of time, and identify if the fuel rail pressure remains below the third threshold for at least a second predefined amount of time. The controller is further configured to determine an open status of the relief valve based, at least in part, on the identification.

Abstract: A fuel delivery system for an engine is provided. The fuel delivery system includes a fuel rail, a pressure sensor, a relief valve, and a controller. The controller is configured to receive a signal indicative of a fuel rail pressure, identify exceeding of the fuel rail pressure beyond a first threshold, identify the fuel rail pressure drop below a second threshold, and initiate a counter for a first predefined amount of time accordingly. The controller is also configured to identify if the fuel rail pressure drops below a third threshold within the first predefined amount of time, and identify if the fuel rail pressure remains below the third threshold for at least a second predefined amount of time. The controller is further configured to determine an open status of the relief valve based, at least in part, on the identification.

Abstract: The subject matter of this specification can be implemented in, among other things, a method that includes pre-registering multiple memory regions for input/output (IO) buffers of a remote direct memory access (RDMA) interface. The method includes receiving a buffer reservation request from a non-system-based user (NSBU) application through an application programming interface (API). The method includes reserving for the NSBU application a first IO buffer. The method includes receiving a request from the NSBU application through the API to access a file in a distributed file system. The method includes receiving data for the file in the first IO buffer from the distributed file system using the RDMA interface or providing data for the file from the first IO buffer to the distributed file system using the RDMA interface. The method includes receiving a request from the NSBU application through the API to free the first IO buffer.

Abstract: The subject matter of this specification can be implemented in, among other things, a method that includes pre-registering, by a processing device at a client device, multiple input/output (IO) buffers at the client device with a remote direct memory access (RDMA) interface at the client device. The client device accesses multiple server devices of a distributed file system using the RDMA interface. The method further includes receiving a request to access a file in the distributed file system from an application at the client device. The method further includes designating a first IO buffer among the IO buffers as a cache for data from the file. The method further includes receiving the data for the file in the first IO buffer from the distributed file system using the RDMA interface.

Abstract: Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom.

Abstract: Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom. The compounds of 1-O-acetylbritannilactone or 1,6-O,O-diacetylbritannilactone are isolated and used for inducing apoptosis in cells and for treating cancer in an animal. Induction of apoptosis comprises contacting cells with a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation. Further, treatment of cancer in an animal comprises administering to an animal a composition comprising the compounds in an amount sufficient to induce Bcl-2 protein phosphorylation to treat the cancer.

Abstract: Compositions and methods for preventing and treating cancer are provided that comprise extracts of Inula britannica or compounds isolated therefrom.