Abstract: A technique for reading the columns (12) and rows (14) of a touch sensor (10) provides several advantages, including scalability to touch sensors with high column/row counts. A simultaneously applied set of column input signals (24) yields a corresponding set of column output signals (34) that are combined into a combined column signal (38) that is transformed into the frequency domain after digitization, to yield column values (48) corresponding to the respective touch sensor columns (12). The same process applied with respect to the touch sensor rows (14) yields a set of row values (50), with evaluation of the frequency-domain column and row values (48, 50) providing the basis for detecting touch inputs to the touch sensor (10).

Abstract: A technique for reading the columns (12) and rows (14) of a touch sensor (10) provides several advantages, including scalability to touch sensors with high column/row counts. A simultaneously applied set of column input signals (24) yields a corresponding set of column output signals (34) that are combined into a combined column signal (38) that is transformed into the frequency domain after digitization, to yield column values (48) corresponding to the respective touch sensor columns (12). The same process applied with respect to the touch sensor rows (14) yields a set of row values (50), with evaluation of the frequency-domain column and row values (48, 50) providing the basis for detecting touch inputs to the touch sensor (10).

Abstract: Methods and apparatus are provided. In an example aspect, a method in a network node of selecting one or more beams for communication with a wireless device and/or measurement by the wireless device is provided. The method comprises determining an indication of a location of a wireless device, determining an indication of motion of the wireless device, determining probabilities that the wireless device will move along each of a plurality of routes based on the indication of location of the wireless device and the indication of motion of the wireless device, and selecting one or more beams served by a base station for communication with the wireless device and/or measurement by the wireless device based on the probabilities.

Abstract: Methods and apparatus are provided. In an example aspect, method of configuring a User Equipment (UE) is provided. The method includes detecting a movement of the UE, determining a context of the UE in response to the detected movement, and configuring at least one parameter of wireless communication between the UE and a base station based on the context of the UE and the detected movement.

Abstract: A method for power management of a first communication device, which has first power resources, comprises detecting a second communication device operating in a same area as the first communication device and having second power resources being less constrained than the first power resources. The method also comprises connecting to the second communication device over a non-cellular connection and delegating to the second communication device to perform cellular connection management measurements for the first communication device through cellular communication with a network node.

Abstract: A method is disclosed—for a wireless communication device served by a network access node—of keeping a time reference at the wireless communication device. The wireless communication device is configured for operation according to at least first and second operational modes, the second operational mode having lower power consumption than the first operational mode. The method comprises (during operation according to the first operational mode) determining (for the second operational mode) desired timings of timing signals to be transmitted from the network access node, and transmitting a request signal to the network access node, wherein the request signal carries information of the desired timings of timing signals to be transmitted from the network access node. In some embodiments, the method further comprises receiving a response signal from the network access node, wherein the response signal carries information of actual timings of timing signals to be transmitted from the network access node.

Abstract: A method for transitioning between user profiles in an electronic user device during use of the electronic user device wherein the electronic user device comprises a fingerprint sensor operatively connected to a touch sensor of the electronic user device is disclosed. The method comprises sensing (103), by the fingerprint sensor, at least a part of a fingerprint at a determined position and area of a detected touch, and determining (104), by a fingerprint controller configured to control the fingerprint sensor, whether the sensed part of the fingerprint corresponds to a registered user of the electronic user device.

Abstract: A method and process to make and use cotton-tipped electrochemical immunosensor for the detection of corona viruses is described. The immunosensor were fabricated by immobilizing the virus antigens on carbon nanofiber-modified screen printed electrodes which were functionalized by diazonium electrografting and activated by EDC/NHS chemistry. The detection of virus antigens were achieved via swabbing followed by competitive assay using fixed amount of antibody in the solution. Ferro/ferricyanide redox probe was used for the detection using square wave voltammetric technique. The limits of detection for our electrochemical biosensors were 0.8 and 0.09 pg/ml for SARS-CoV-2 and MERS-CoV, respectively indicating very good sensitivity for the sensors. Both biosensors did not show significant cross reactivity with other virus antigens such as influenza A and HCoV, indicating the high selectivity of the method.

Abstract: A method for detecting a SARS-Cov-2 protease in a biological sample is provided. The method includes contacting the biological sample with a fluorescent probe based sensor, wherein the sensor comprises an L-Histidine-D-aspartic acid peptide substrate, a fluorophore, and a quencher molecule; and detecting the SARS-Cov-2 protease when an increase in fluorescence is observed.

Abstract: The developed long and short aptamer sequences can be used as high affinity and specificity tools to analyze the drug Dabigatran etexilate for therapeutic drug monitoring, pharmacokinetic and naturalization studies. Using the technique by performing several rounds of selection and enrichment with a randomized 60-mer DNA library, a number of specific aptamer sequences were successfully selected for Dabigatran etexilate. We evaluated the binding affinity and specificity of the generated aptamers showing dissociation constants (kd) ranging from 47-312 nM and very weak or no cross-reactivity to other analytes. Complimentary sequences labelled with a fluorophore and a quencher was used for mapping the binding region within the aptamer by monitoring the change in the fluorescence signal. A truncated sequence was used to construct a turn-on fluorescence sensor.

Abstract: An electrochemical screening method for the selection of DNA aptamers against 11-deoxycortisol (11-DCL) using gold electrode for target immobilization is described. The gold electrode is used as solid matrix instead of the beads for SELEX. The selection steps (SELEX) are performed on the 11-DC modified electrode directly as the DNA library in the first round or the enriched DNA pools in the subsequent rounds were incubated on the electrode, then the unbound DNA is washed and the bound DNA is measured directly by square wave voltammetry. Then elution of the bound DNA is performed for further use.

Abstract: There is provided a biosensor for detecting pathogens in a sample. The detection is based on colorimetry. The biosensor comprises one or more particle supports and a magnetic material attached to a planar support. The biosensor embodies magnetic particles that are functionalized using a chemical substrate specific to the pathogens to be detected. The sensor may allow for a simultaneous detection of a plurality of pathogens in the sample. Also, the sensor may be disposable. Moreover, the sensor may be integrated in a portable detection device.

Abstract: A multiplex hand-held diagnostic biosensor, using two inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was constructed made to potentially detect Periodontitis at an early stage is described. The use of magnetic nanoparticle biosensor method used as a device was based on the measurement of proteolytic activity using specific proteases probes. The magnetic nanoparticle biosensor device is capable of specific and quantitative detection of HNE and Cathepsin-G in solution and in spiked saliva samples with a lower detection limit of 1 pg/mL and 100 fg/mL for HNE and Cathepsin-G, respectively.

Abstract: There is provided a method of detecting an analyte in a sample. The method is based on colorimetry and also on the binding affinity between the analyte and a chemical substrate which may be a recognition receptor thereof. The method involves a support and a colored carrier. A kit for use in the detection is also provided.

Abstract: High affinity DNA aptamers Seq ID#1-8 for HbA1C and tHb were successfully selected using SELEX after 11 rounds of selection. The tested aptamers bind to HbA1C with dissociation constants in the nanomolar range with the highest affinity aptamer, Seq ID#6, exhibiting a Kd of 2.8 nM. Another aptamer sequence (Seq ID #4) which showed high binding affinity to tHb with a Kd of 2.7 nM was also selected. The HbA1C and tHb-specific aptamers were then applied for the detection of HbA1C % using a voltammetric aptasensor array platform showing remarkable sensitivity and selectivity. The aptasensor array platform was validated using standard human whole blood samples and demonstrated linearity over wide concentration range. The developed platform is superior to current methodologies due to its simplicity, stability and lower cost which will facilitate the early and accurate diagnosis of diabetes.

Abstract: High affinity DNA aptamers Seq ID#1-8 for HbA1C and tHb were successfully selected using SELEX after 11 rounds of selection. The tested aptamers bind to HbA1C with dissociation constants in the nanomolar range with the highest affinity aptamer, Seq ID#6, exhibiting a Kd of 2.8 nM. Another aptamer sequence (Seq ID #4) which showed high binding affinity to tHb with a Kd of 2.7 nM was also selected. The HbA1C and tHb-specific aptamers were then applied for the detection of HbA1C % using a voltammetric aptasensor array platform showing remarkable sensitivity and selectivity. The aptasensor array platform was validated using standard human whole blood samples and demonstrated linearity over wide concentration range. The developed platform is superior to current methodologies due to its simplicity, stability and lower cost which will facilitate the early and accurate diagnosis of diabetes.

Abstract: There is provided a method of detecting an analyte in a sample. The method is based on colorimetry and also on the binding affinity between the analyte and a chemical substrate which may be a recognition receptor thereof. The method involves a support and a colored carrier. A kit for use in the detection is also provided.

Abstract: There is provided a biosensor for detecting pathogens in a sample. The detection is based on colorimetry. The biosensor comprises one or more particle supports and a magnetic material attached to a planar support. The biosensor embodies magnetic particles that are functionalized using a chemical substrate specific to the pathogens to be detected. The sensor may allow for a simultaneous detection of a plurality of pathogens in the sample. Also, the sensor may be disposable. Moreover, the sensor may be integrated in a portable detection device.

Abstract: A multiplex hand-held diagnostic biosensor, using two inflammatory salivary biomarkers, Human Neutrophil Elastase (HNE) and Cathepsin-G, was constructed made to potentially detect Periodontitis at an early stage is described. The use of magnetic nanoparticle biosensor method used as a device was based on the measurement of proteolytic activity using specific proteases probes. The magnetic nanoparticle biosensor device is capable of specific and quantitative detection of HNE and Cathepsin-G in solution and in spiked saliva samples with a lower detection limit of 1 pg/mL and 100 fg/mL for HNE and Cathepsin-G, respectively.

Abstract: There is provided a portable device for detecting pathogens in a sample, the detection being based on an assay involving one or more reagents and heat. The device comprises a flexible substrate having a plurality of spaced apart reservoirs along its length, each reservoir adapted for receiving reagents and the sample, the substrate being secured to a pair of spaced apart reels and movable there between by rolling. Also, the device comprises heating means which can be secured to one of the two reels.