Patents by Inventor Mohanram Sivaraja

Mohanram Sivaraja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput in vitro screening assays for modulators of nucleic acid helicases
    Patent number: 6569619
    Abstract: The present invention provides solid phase assays for measuring helicase activity in the presence or absence of a potential helicase activity modulator. High throughput methods, compositions, kits and integrated systems are provided for detecting helicase activity in vitro and for measuring the effect of potential helicase activity modulators.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: May 27, 2003
    Assignee: Tularik, Inc.
    Inventor: Mohanram Sivaraja
  • High throughput in vitro screening assays for transcription modulators
    Patent number: 6183956
    Abstract: High-throughput in vitro assays are provided for identifying modulators of transcription activity and RNA expression. New assays, related compositions, apparatus and integrated systems are provided.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: February 6, 2001
    Assignee: Tularik, Incorporated
    Inventors: Mohanram Sivaraja, Berta Strulovici, Osvaldo A. Flores
  • High throughput screening assays for nucleic acid ligase modulators
    Patent number: 6153384
    Abstract: Screening assays for identifying ligase activity modulators are provided, in both solid phase and liquid phase formats. Solid phase formats detect ligase activity by ligating a labelled nucleic acid to a capture nucleic acid in the presence of the ligase modulator and detection of the labelled nucleic acid. Liquid phase assays detect ligation-dependent changes in interactive labels between nucleic acids such as proximity quenching of fluorescent labels. Compositions, apparatus and integrated systems for assays are also provided.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: November 28, 2000
    Assignee: Tularik Inc.
    Inventors: Anthony Simon Lynch, Ashok Ramesh Sanadi, Mohanram Sivaraja
  • High-throughput screening assays for modulators of primase activity
    Patent number: 6043038
    Abstract: This invention provides novel assays for primase activity and for identifying modulators of primase activity. The assays include both solid-phase and liquid-phase methods that are amenable to high throughput screening methods. The assays of the invention are readily adaptable to numerous types of primase, and are capable of identifying novel classes of primase activity modulators.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: March 28, 2000
    Assignee: Tularik, Inc.
    Inventors: Mohanram Sivaraja, Ashok Sanadi, M. Gregory Peterson
  • High-throughput screening assay for inhibitors of nucleic acid helicases
    Patent number: 5705344
    Abstract: The invention provides screening assays for identifying an inhibitor of a pathogenic helicase activity, e.g. a helicase derived from a pathogenic infectious organism such as a bacterium, protozoan or fungus. Helicase activity is detected by the solid-phase, preferential capture of retained (non-liberated) single-stranded nucleic acid comprising a detectable label.
    Type: Grant
    Filed: March 14, 1996
    Date of Patent: January 6, 1998
    Assignee: Tularik, Inc.
    Inventors: Heidi Giordano, Michael G. Peterson, Mohanram Sivaraja