Patents by Inventor Mohit B. Bhatia
Mohit B. Bhatia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220096352Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.Type: ApplicationFiled: May 13, 2021Publication date: March 31, 2022Applicant: Celularity Inc.Inventors: Mohit B. BHATIA, Chris LUGO, Qian YE, James W. EDINGER
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Publication number: 20210145872Abstract: Provided herein are methods for forming three-dimensional tissues in vivo. In one embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells. In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells and at least one composition that comprises an extracellular matrix (ECM). In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells, at least one composition that comprises an extracellular matrix (ECM), and at least one other additional components.Type: ApplicationFiled: June 23, 2020Publication date: May 20, 2021Applicant: Celularity Inc.Inventors: Robert J. HARIRI, Mohit B. BHATIA, Wolfgang HOFGARTNER, Jia-Lun WANG, Qian YE
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Publication number: 20190089124Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.Type: ApplicationFiled: March 14, 2018Publication date: March 21, 2019Applicant: CELULARITY, INC.Inventors: Mohit B. Bhatia, Chris Lugo, Qian Ye, James W. Edinger
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Publication number: 20170128625Abstract: Provided herein are organoids comprising decellularized placental vascular scaffold comprising, or consisting of, a decellularized placental vascular scaffold, and methods of making and using the same.Type: ApplicationFiled: June 15, 2016Publication date: May 11, 2017Applicant: ANTHROGENESIS CORPORATIONInventors: Mohit B. Bhatia, Robert J. Hariri, Wolfgang Hofgartner, Jia-Lun Wang, Qian Ye
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Publication number: 20170096473Abstract: The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.Type: ApplicationFiled: December 19, 2016Publication date: April 6, 2017Applicant: Anthrogenesis CorporationInventors: Mohit B. Bhatia, Chris Lugo, Qian Ye, James W. Edinger
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Publication number: 20170056479Abstract: Provided herein are placental extracellular matrix (ECM) compositions and methods of making the same. Also provided herein are uses of the placental ECM compositions provided herein.Type: ApplicationFiled: November 1, 2016Publication date: March 2, 2017Inventors: Mohit B. BHATIA, Uri HERZBERG, Aleksandr KAPLUNOVSKY, Raihana ZAKA, Qian Ye
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Patent number: 9575054Abstract: Provided herein are methods of evaluating potential antitumor compounds, and thereby identifying antitumor compounds, using placenta or a portion thereof and tumor cells, and compositions for accomplishing the same. In one embodiment, provided herein is a method of determining whether a potential antitumor compound is effective against a plurality of tumor cells, comprising introducing a plurality of tumor cells to, e.g., into or onto, a mammalian placenta or portion thereof; contacting said plurality of tumor cells for a period of time with said antitumor compound; and determining whether said antitumor compound is effective against said tumor cells, wherein said antitumor compound is effective against said tumor cells if said antitumor compound over said period of time reduces the number of said tumor cells or reduces the growth rate of said tumor cells.Type: GrantFiled: February 22, 2013Date of Patent: February 21, 2017Assignee: Anthrogenesis CorporationInventors: Robert J. Hariri, Mohit B. Bhatia, Qian Ye
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Publication number: 20160030635Abstract: Provided herein are methods of producing extracellular matrix (ECM) that are superior to previously-described methods. Extracellular matrix (ECM) comprises protein that forms many structures in the body including tendons, ligaments, and sheets that support skin and internal organs. There remains a need in the art for ECM compositions that have improved cell attachment characteristics and methods of making such ECM compositions.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: ANTHROGENESIS CORPORATIONInventors: Mohit B. Bhatia, Aleksandr Kaplunovsky, Xuan Guo
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Publication number: 20150313948Abstract: Provided herein are uses of compositions comprising extracellular matrix (ECM) and compositions comprising ECM components in the treatment of non-dental oral lesions.Type: ApplicationFiled: December 6, 2013Publication date: November 5, 2015Applicant: ANTHROGENESIS CORPORATIONInventors: Robert J. Hariri, Jodi P. Gurney, Mohit B. Bhatia, Wolfgang Hofgartner
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Publication number: 20150246072Abstract: Provided herein are methods for forming three-dimensional tissues in vivo. In one embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells. In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells and at least one composition that comprises an extracellular matrix (ECM). In another embodiment, provided herein is a method for forming a three-dimensional tissue in vivo, comprising depositing on a surface that is in or on a subject at least one composition that comprises cells, at least one composition that comprises an extracellular matrix (ECM), and at least one other additional components.Type: ApplicationFiled: September 3, 2013Publication date: September 3, 2015Applicant: ANTHROGENESIS CORPORATIONInventors: Mohit B. Bhatia, Robert J. Hariri, Wolfgang Hofgartner, Jia-Lun Wang, Qian Ye
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Publication number: 20150224226Abstract: Provided herein are methods of generating tissues and organs in vitro or ex vivo comprising depositing cells and extracellular matrix onto a surface, as well as methods of using such tissues and organs. In one embodiment, the cells and ECM used in accordance with the methods for generating tissues (e.g., three-dimensional tissues) and organs described herein are deposited as part of the same composition. In another embodiment, the cells and ECM used in accordance with the methods for generating tissues (e.g., three-dimensional tissues) and organs described herein are deposited as part of different compositions.Type: ApplicationFiled: September 3, 2013Publication date: August 13, 2015Applicant: ANTHROGENESIS CORPORATIONInventors: Mohit B. Bhatia, Robert J. Hariri, Wolfgang Hofgartner, Jia-Lun Wang, Qian Ye
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Publication number: 20150017663Abstract: Provided herein are methods of evaluating potential antitumor compounds, and thereby identifying antitumor compounds, using placenta or a portion thereof and tumor cells, and compositions for accomplishing the same. In one embodiment, provided herein is a method of determining whether a potential antitumor compound is effective against a plurality of tumor cells, comprising introducing a plurality of tumor cells to, e.g., into or onto, a mammalian placenta or portion thereof; contacting said plurality of tumor cells for a period of time with said antitumor compound; and determining whether said antitumor compound is effective against said tumor cells, wherein said antitumor compound is effective against said tumor cells if said antitumor compound over said period of time reduces the number of said tumor cells or reduces the growth rate of said tumor cells.Type: ApplicationFiled: February 22, 2013Publication date: January 15, 2015Applicant: Anthrogenesis CorporationInventors: Robert J. Hariri, Mohit B. Bhatia, Qian Ye
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Publication number: 20150017140Abstract: Provided herein are organoids comprising decellularized placental vascular scaffold comprising, or consisting of, a decellularized placental vascular scaffold, and methods of making and using the same.Type: ApplicationFiled: December 21, 2012Publication date: January 15, 2015Applicant: Anthrogenesis CorporationInventors: Mohit B. Bhatia, Robert J. Hariri, Wolfgang Hofgartner, Jia-Lun Wang, Qian Ye
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Publication number: 20120171161Abstract: Provided herein are compositions comprising placental stem cells and platelet rich plasma. Also provided herein are methods of treating an individual suffering from a disease or condition that would benefit from reduced inflammation, promotion of angiogenesis, and enhanced healing, comprising administering a therapeutically effective amount of a composition comprising placental stem cells and platelet rich plasma, as described herein, to said individual in an amount and for a time sufficient for detectable improvement of said disease or condition.Type: ApplicationFiled: December 29, 2011Publication date: July 5, 2012Inventors: Sascha Abramson, Mohit B. Bhatia, Uri Herzberg
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Publication number: 20120171180Abstract: Provided herein are methods of using amnion derived adherent cells, and populations of, and compositions comprising, such cells, in the modulation of an immune response. In various embodiments, the immune response is graft-versus-host disease, an allergy, asthma, or an immune-related disease or disorder, e.g., an autoimmune disease.Type: ApplicationFiled: December 29, 2011Publication date: July 5, 2012Inventors: Sascha Abramson, Mohit B. Bhatia, Uri Herzberg
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Patent number: 6133018Abstract: 2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.Type: GrantFiled: March 10, 1999Date of Patent: October 17, 2000Assignee: CelgroInventors: Wei Wu, Mohit B. Bhatia, Craig M. Lewis, Wei Lang, Alice L. Wang, George W. Matcham