Abstract: A system and method for data storage, transfer, synchronization, and security using recursive encoding, wherein data is deconstructed into chunklets, and is processed through a series of reference code libraries that reduce the data to a sequence of reference codes, and where the output of each reference library is used as the input to the next.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Abstract: A system for storing and transmitting data in a highly compact format comprising reference codes to data chunklets contained in a library, wherein the data are retrieved after transmission or storage by re-constructing the data from the chunklets in the library using the reference codes. One version of the system contains proprietary libraries which act as a form of data security. Another version of the system contains a standardized version of the library encoded onto the firmware of a broad range of computing devices, allowing optimized storage and transmission of data between two such devices equipped with the system.

Abstract: A system for storing and transmitting data in a highly compact format comprising reference codes to data chunklets contained in a library, wherein the data are retrieved after transmission or storage by re-constructing the data from the chunklets in the library using the reference codes. One version of the system contains proprietary libraries which act as a form of data security. Another version of the system contains a standardized version of the library encoded onto the firmware of a broad range of computing devices, allowing optimized storage and transmission of data between two such devices equipped with the system.

Abstract: A system and method for high-speed transfer of small data sets, that provides near-instantaneous bit-level lossless compression, that is ideal for communications environments that cannot tolerate even small amounts of data corruption, have very low latency tolerance, where data has a low entropy rate, and where every bit costs the user bandwidth, power, or time so that deflation is worthwhile. Where some loss of data can be tolerated, the system and method can be configured for use as lossy compression.

Abstract: A system for storing and transmitting data in a highly compact format comprising reference codes to data chunklets contained in a library, wherein the data are retrieved after transmission or storage by re-constructing the data from the chunklets in the library using the reference codes. One version of the system contains proprietary libraries which act as a form of data security. Another version of the system contains a standardized version of the library encoded onto the firmware of a broad range of computing devices, allowing optimized storage and transmission of data between two such devices equipped with the system.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.

Abstract: Methods, systems, and computer readable media perform predictive modeling of gene activity. The methods may comprise obtaining the amino acid and/or nucleic acid sequence of a portion of the at least one gene from a biological sample obtained from a subject; comparing the amino acid and/or nucleic acid sequence of the portion of the at least one gene to a database of sequences for the portion of the at least one gene and for which the biological activity of the at least one gene has been evaluated; and applying a generalization of ridge regression analysis to estimate the effects of individual mutations in the at least one gene. A model is based on generalization of ridge regression (GRR) analysis to estimate the effects of individual mutations in at least one gene for the subject. At least one gene may comprise the reverse transcriptase and protease genes of an HIV vims.

Abstract: Processes for identification of binding sites on protein molecules such as epitopes are provided. The disclosed methods in some embodiments use a combination of protein sequence data, structural information, experimental data on binding affinity, and computational modeling in order to identify binding sites on protein molecules. Systems and computer readable media for implementing the disclosed methods are provided. Also provided are compositions comprising a binding site or antibody that interacts with the binding site as an active ingredient and methods of using such compositions.

Abstract: Methods and compositions for the efficient and accurate determination of HIV susceptibility to a non-nucleoside reverse transcriptase inhibitor (NNRTI) are provided. In certain aspects, the methods involve detecting in a biological sample a nucleic acid encoding an HIV reverse transcriptase that comprises a mutation at codon 188, wherein the presence of the reverse transcriptase-encoding nucleic acid in the biological sample indicates that the HIV has a decreased susceptibility to an NNRTI. In certain embodiments, the HIV also contains one or more secondary mutations in reverse transcriptase. Also provided are methods for selecting a treatment for an HIV patient and methods for determining the selective advantage of a mutation or mutation profile.

Abstract: The present invention relates generally to methods of accurately quantifying HER2 and/or p95 expression in subjects with a HER2 positive cancer and indicating the risk of brain relapse in such patients.