Abstract: Disclosed herein are methods of treating Rett syndrome comprising administering trofinetide to a subject in need thereof in which a dosage is provided that may reduce or avoid underexposure, e.g., in low body weight subjects, and/or provide other benefits.

Abstract: In accordance with the invention is an fentanyl-containing dosage form designed for transmucosal delivery which includes both an effervescent couple and a pH adjusting substance which can be administered to patients suffering from both pain and mucositis. Also provided is a method of treating pain in a patient having mild oral mucositis by administering a fentanyl-containing dosage form designed for transmucosal delivery.

Abstract: In accordance with the invention is an fentanyl-containing dosage form designed for transmucosal delivery which includes both an effervescent couple and a pH adjusting substance which can be administered to patients suffering from both pain and mucositis. Also provided is a method of treating pain in a patient having mild oral mucositis by administering a fentanyl-containing dosage form designed for transmucosal delivery.

Abstract: An improved feeding device for infants comprises a sharply pointed, tapered hollow stem of plastic or similar rigid material, to which a flexible nipple is attached at the broad, bored end. The shaft of the tapered stem has at its periphery an integrally molded fastening device, such as screw threads, expansion members or bayonet-type locking grooves. The stem's pointed end is used to perforate the wall of a prefilled, sealed container. Further insertion causes the fastening device to firmly attach the stem to the container wall, the nipple then being ready for use.