Patents by Inventor Mona S. Legator

Mona S. Legator has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
    Patent number: 6569626
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: May 27, 2003
    Assignee: Vysis, Inc.
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Probe compositions for chromosome identification and methods
    Publication number: 20020025523
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Application
    Filed: June 21, 2001
    Publication date: February 28, 2002
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
    Patent number: 6277569
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: August 21, 2001
    Assignee: Vysis, Inc.
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Methods for genome identification using direct label probe composition
    Patent number: 5789161
    Abstract: Direct label probe compositions which counterstain genomic DNA are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the total genomic DNA of a multi-chromosomal organism, especially man, and the segment mixture is approximately representative of such total genomic DNA. These probe compositions can be used concurrently or sequentially with other probe compositions. Instead of intercalating with DNA as in prior art chemical counterstains, these probe compositions hybridize with complementary segments that are present in the genomic DNA of a specimen.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Assignee: AMOCO Corporation
    Inventors: Larry E. Morrison, Mona S. Legator, Michael L. Bittner
  • Methods for detection by in situ hybridization of multiple chromosomes or regions thereof
    Patent number: 5776688
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: July 7, 1998
    Assignee: Vysis, Inc.
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Probe compositions for chromosome identification and methods
    Patent number: 5663319
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 2, 1997
    Assignee: Vysis, Inc.
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator
  • Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
    Patent number: 5491224
    Abstract: Direct label probe compositions which stain DNA of a preselected single chromosome or region of a chromosome of a multi-chromosomal genome are provided that comprise mixed DNA segments which are covalently bound to fluorophore groups through linking groups. The mixed DNA segments are derived from the DNA present in the preselected chromosome or chromosome region. These probe compositions can be used concurrently or sequentially with other probe compositions.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: February 13, 1996
    Inventors: Michael L. Bittner, Larry E. Morrison, Mona S. Legator