Patents by Inventor Monia Draghi

Monia Draghi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240358797
    Abstract: The present disclosure provides technologies for achieving treatment of cancer. The present disclosure provides methods and compositions for the treatment of cancer using oncoselective construct designs that can be used to encode payloads of high therapeutic interest. The present disclosure recognizes that treatment of individuals suffering from cancer with engineered nucleic acids of the disclosure in combination with immune checkpoint therapy provides unique advantages.
    Type: Application
    Filed: May 6, 2024
    Publication date: October 31, 2024
    Inventors: Monia DRAGHI, Rudy CHRISTMAS, Cafer OZDEMIR, Burak YILMAZ, Yusuf ERKUL, Manfred KRAUS
  • Publication number: 20200109195
    Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.
    Type: Application
    Filed: May 21, 2019
    Publication date: April 9, 2020
    Applicant: COMPASS THERAPEUTICS LLC
    Inventors: Jennifer Watkins, Michael March Schmidt, Monia Draghi, Amanda Frank Oliphant, Sara Marie Halmos, Thomas Joseph Schuetz, Jason Michael Lajoie, Allison Nelson
  • Publication number: 20200079867
    Abstract: The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells (e.g., cancer cells) having a low level of expression of the tumor antigen.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 12, 2020
    Applicant: COMPASS THERAPEUTICS LLC
    Inventors: Jennifer Watkins, Michael March Schmidt, Monia Draghi, Amanda Frank Oliphant, Sara Marie Halmos, Thomas Joseph Schuetz, Jason Michael Lajoie, Allison Nelson