Abstract: The present invention relates to complexes of nocardamine (desferrioxamine E) with at least one metal, specifically with Zn2+ or Ga3+ or silver or gold or any combinations thereof. The invention further provides procedures for the preparation of the complexes and pharmaceutical compositions comprising said complexes or any combinations of said complexes, as well as methods using the compositions and complexes of the invention in modulating cytokine levels in a subject and thereby treating inflammation-associated disorders.

Abstract: The present invention provides pharmaceutical compositions comprising a metal-desferrioxamine B complex or a combination thereof, for preventing, inhibiting, reducing or ameliorating neurodegeneration, thereby treating diseases, disorders, or conditions characterized by or associated with neurodegeneration; as well as methods of use.

Abstract: The present invention relates to an iron chelator combination, more specifically a combination of a non-iron metal-desferrioxamine B complex and an additional iron chelator, for preventing, inhibiting, reducing or ameliorating iron overload or elevated levels of labile iron.

Abstract: The present invention provides pharmaceutical compositions comprising a metal-desferrioxamine B complex or a combination thereof, for preventing, inhibiting, reducing or ameliorating neurodegeneration, thereby treating diseases, disorders, or conditions characterized by or associated with neurodegeneration; as well as methods of use.

Abstract: The present invention relates to complexes of nocardamine (desferrioxamine E) with at least one metal, specifically with Zn2+ or Ga3+ or silver or gold or any combinations thereof. The invention further provides procedures for the preparation of the complexes and pharmaceutical compositions comprising said complexes or any combinations of said complexes, as well as methods using the compositions and complexes of the invention in modulating cytokine levels in a subject and thereby treating inflammation-associated disorders.

Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.

Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.

Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.

Abstract: Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.

Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.

Abstract: Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.

Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.

Abstract: A pharmaceutical composition comprises a gallium complex of desferrioxamine r penicillamine as active ingredients therein, in combination with a pharmacologically acceptable carrier. The gallium desferrioxamine or gallium penicillamine complex are useful in the treatment of free radical-induced pathological conditions; the treatment of injury resulting from ischemic insult to the heart, brain or kidney; the treatment of thalassemia; the treatment of hemochromatosis; the treatment of Wilson's disease; the treatment of paraquat toxicity; or for exchanging gallium for iron.

Abstract: The invention provides a composition for protecting the heart from myocardial ischemia and reperfusion injury as well as for reducing post-ischemic damage, improving cardiac function and serving as a hypothermic cardiac preservative solution comprising N,N,N'N'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) as active ingredient therein.

Abstract: The invention provides a pharmaceutical composition comprising a zinc complex of desferrioxamine or penicillamine as active ingredient therein in combination with a pharmacologically acceptable carrier.