Abstract: The present invention is an eyeglasses holder which forms a detachable coupling between a flat base and a nosepiece. The flat base has front channels for accommodating an interlocking wedge structure of the nosepiece to provide the detachable coupling. The nosepiece comprises an A-shaped frame structure and a pair of interlocking wedges, where each interlocking wedge is connected to the A-shaped frame structure by an interconnecting shaft. The pair of interlocking wedges can be slid into the front channels of the flat base and locked therein by a pair of small protrusions. The two interconnecting shafts can be squeezed inwardly to cause the pair of interlocking wedges to shift and avoid the small protrusions, so that the pair of interlocking wedges can be released from the front channels of the flat base. The present invention is also a multiplicity of eyeglass holders each being detachably assembled by a base piece and a noise piece as described above.