Patents by Inventor Morris J. Karnovsky

Morris J. Karnovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extraluminal regulation of the growth and repair of tubular structures in vivo
    Patent number: 5540928
    Abstract: A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: July 30, 1996
    Assignee: President and Fellows of Harvard College
    Inventors: Elazer R. Edelman, David H. Adams, Morris J. Karnovsky
  • Extraluminal regulation of the growth and repair of tubular structures in vivo
    Patent number: 5527532
    Abstract: A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue. Administration of substances such as heparin over sustained, prolonged periods controls intimal hyperplasia and smooth muscle cell proliferation, even at doses that are insufficient to have such a beneficial effect if administered systemically. Bolus administration of such compounds at higher doses typically used to achieve systemic effects may have no effect or may even produce adverse effects.
    Type: Grant
    Filed: September 2, 1993
    Date of Patent: June 18, 1996
    Assignee: President and Fellows of Harvard College
    Inventors: Elazer R. Edelman, David H. Adams, Morris J. Karnovsky
  • Extraluminal regulation of the growth and repair of tubular structures in vivo
    Patent number: 5455039
    Abstract: A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: October 3, 1995
    Assignee: President and Fellows of Harvard College
    Inventors: Elazer R. Edelman, David H. Adams, Morris J. Karnovsky