Abstract: A system for filtering or treating blood of a subject is provided herein. The system includes a bone port for establishing fluid communication with a bone marrow of the bone and a return port for returning blood from the bone marrow to a circulation of the subject. The system further includes a blood treatment or filtering device interposed between the bone and return ports thereby establishing a mini-circulatory system.

Abstract: Bone bypass shunts and methods using thereof. Method for affecting a pathophysiological condition in a body of a live subject includes exemplary steps/procedures of: connecting an inlet port of a bone bypass shunt to a first bone portion adjacent a first bone marrow location such that inlet port lumen of inlet port facilitates fluid communication with blood accumulated or flowing at first blood marrow location; connecting outlet port of the bone bypass shunt to second bone portion adjacent second bone marrow location, such that outlet port lumen of outlet port facilitates fluid communication with bone marrow; a formed cavity, or/and bone marrow vasculature, located at second bone marrow location; via inlet port lumen, removing a chosen volume of blood from first bone marrow location; and via outlet port lumen, delivering chosen volume of blood to the second bone marrow location.

Abstract: Method for filtering blood plasma flowing through bone marrow of a subject, including: providing an active filtering device having a pressure increasing mechanism and a filter material configured for filtering flowing blood plasma; attaching the active filtering device to bone inside the subject, the bone includes marrow through which flows blood plasma; exposing filter material to flowing blood plasma; applying pressure increasing mechanism so as to create pressure gradient between flowing blood plasma and filter material; filtering flowing blood plasma; and removing excess fluid from flowing blood plasma. During filtration, water and solutes of blood plasma move and pass through filter material, and waste substances of blood plasma are captured and retained by filter material, forming filtered flowing blood plasma.

Abstract: A system for filtering or treating blood of a subject is provided herein. The system includes a bone port for establishing fluid communication with a bone marrow of the bone and a return port for returning blood from the bone marrow to a circulation of the subject. The system further includes a blood treatment or filtering device interposed between the bone and return ports thereby establishing a mini-circulatory system.

Abstract: A device for filtering blood is provided herein. The device includes a device body configured for at least partial implantation within a marrow of a bone and a filter disposed on or within the device body and being for filtering blood flowing through the marrow.

Abstract: A device and system for monitoring an analyte in a subject and for controlling blood analyte levels are provided. The device and system include a sensor element which is designed and configured for detecting the analyte in blood flowing through the bone of the subject.

Abstract: The present invention relates to a method for the treatment of HIV-associated nephropathy by administration of glycosaminoglycans, and in particular, by the administration of sulodexide.

Abstract: The present invention relates to a method for the treatment of HIV-associated nephropathy by administration of glycosaminoglycans, and in particular, by the administration of sulodexide.

Abstract: The invention concerns a hardware-software system comprising information on the three-dimensional structure and nature of certain regions in protein kinases. The invention also concerns methods for screening for or synthesizing candidate chemical compounds for regulating kinase activity based on this information.

Abstract: The present invention relates to a method for the treatment of HIV-associated nephropathy by administration of glycosaminoglycans, and in particular, by the administration of sulodexide.

Abstract: The present invention is directed to methods for preventing or treating inflammatory bowel disease by administering a composition comprising a therapeutically or prophylactically effective amount of a composition comprising between about 60% to 90% iduronylglycosaminoglycan sulfate and between about 10% to 40% dermatan sulfate, or a pharmaceutically acceptable salt, solvate, hydrate, or clathrate thereof. In a particular embodiment, a therapeutically or prophylactically effective amount of a composition comprising sulodexide, or a pharmaceutically acceptable salt, solvate, hydrate, or clathrate thereof is administered. The composition to be administered may also comprise one or more additional active ingredients selected from the group consisting of steroids, aminosalicylates, short-chain fatty acids, thioguanine derivatives, antibiotics, biological agents, antidepressants, and pain-relievers.

Abstract: The invention relates to a process for culturing cells by introducing the cells into the bone or bone marrow of a mammal. The invention also relates to a method for delivering a biologically active substance, including a nucleic acid, vector, protein or pharmaceutical composition to a mammal by introducing the substance into the bone or bone marrow.