Abstract: The present disclosure encompasses engineered meganucleases that bind and cleave recognition sequences within a dystrophin gene. The present disclosure also encompasses methods of using such engineered meganucleases to make genetically modified cells. Further, the disclosure encompasses pharmaceutical compositions comprising engineered meganuclease proteins, or polynucleotides encoding engineered meganucleases of the disclosure, and the use of such compositions for the modification of a dystrophin gene in a subject, or for treatment of Duchenne Muscular Dystrophy.

Abstract: Disclosed herein are recombinant meganucleases engineered to bind and cleave a recognition sequence in the mitochondrial DNA (mtDNA) of a eukaryotic cell, such as a plant cell. The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human mitochondrial DNA (mtDNA). The disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells, and to a population of genetically-modified eukaryotic cells wherein the mtDNA has been having modified or edited.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Clutch kits and methods for converting a stock clutch assembly and the clutch assemblies resulting therefrom. Such a method entails modifying a stock clutch assembly comprising a stock drum and stock friction and driving plates installed in an interior cavity of the drum. The method includes securing a pressure plate to the drum with threads to enclose stock or modified friction and driving plates within the interior cavity of the drum. The pressure plate can be configured to axially externally extend the interior cavity of the drum so that additional friction and/or driving plates may accommodated within the interior cavity.

Abstract: A graphics processing system comprises a memory that stores graphics data. The graphics data stored in the memory is accessible using virtual memory addresses that map to physical memory addresses in the memory. The graphics processing system further comprises page merging circuitry configured to use metadata provided for a set of graphics data to determine whether any pages of the set of graphics data are similar to each other. The pages of the set of graphics data that are determined as being similar to each other are merged by mapping the virtual memory addresses for those pages to the same physical memory address in the memory. The page merging process can provide a way to reduce the number of physical memory addresses needed to store the pages of the set of graphics data in the memory.

Abstract: Clutch kits and methods for converting a stock clutch assembly and the clutch assemblies resulting therefrom. Such a method entails modifying a stock clutch assembly comprising a stock drum and stock friction and driving plates installed in an interior cavity of the drum. The method includes securing a pressure plate to the drum with threads to enclose stock or modified friction and driving plates within the interior cavity of the drum. The pressure plate can be configured to axially externally extend the interior cavity of the drum so that additional friction and/or driving plates may accommodated within the interior cavity.

Abstract: A graphics processing system comprises a memory that stores graphics data. The graphics data stored in the memory is accessible using virtual memory addresses that map to physical memory addresses in the memory. The graphics processing system further comprises page merging circuitry configured to use metadata provided for a set of graphics data to determine whether any pages of the set of graphics data are similar to each other. The pages of the set of graphics data that are determined as being similar to each other are merged by mapping the virtual memory addresses for those pages to the same physical memory address in the memory. The page merging process can provide a way to reduce the number of physical memory addresses needed to store the pages of the set of graphics data in the memory.

Abstract: A system for making cyclohexylbenzene starting from benzene and hydrogen includes a first benzene preparation column, a hydroalkylation reactor, a dehydrogenation reactor, a second distillation column for cyclohexylbenzene separation, a third distillation column for cyclohexylbenzene purification, a transalkylation reactor, and a fourth distillation column for separating cyclohexylbenzene from transalkylation effluent. All components are integrated to achieve a high-purity cyclohexylbenzene product produced with a high yield and high overall energy efficiency.

Abstract: In a process for producing phenol, a cleavage feed comprising cyclohexylbenzene hydroperoxide is supplied to a cleavage reaction zone and a cleavage reaction mixture comprising the cleavage feed is contacted in the cleavage reaction zone with a solid acid catalyst under conditions effective to produce a cleavage effluent comprising phenol and cyclohexanone. The cleavage effluent is then divided into at least a cleavage product and a cleavage recycle and the cleavage recycle and a polar solvent is supplied to the cleavage reaction zone to produce the cleavage reaction mixture with the cleavage feed. Preferably, the polar solvent is combined with the cleavage recycle before being charged into the cleavage reaction zone.

Abstract: Disclosed herein is a process for dehydrogenating a saturated cyclic hydrocarbon and/or 5-membered ring compound with a dehydrogenation catalyst. The dehydrogenation catalyst comprises: (i) 0.05 wt % to 5 wt % of a metal selected from Group 14 of the Periodic Table of Elements; and (ii) 0.1 wt % to 10 wt % of a metal selected from Groups 6 to 10 of the Periodic Table of Elements. The process is conducted under dehydrogenation conditions effective to dehydrogenate at least a portion saturated cyclic hydrocarbon and/or 5-membered ring compound.

Abstract: A hydroalkylation catalyst comprising a molecular sieve and a compound of a hydrogenation metal is activated by treating the catalyst at a temperature of less than about 250° C. in the presence of hydrogen.

Abstract: Disclosed are (i) a process for making cyclohexylbenzene by benzene hydroalkylation with a low methylcyclopentylbenzene selectivity; and (ii) a process of making phenol and/or cyclohexanone from cyclohexylbenzene including a step of removing methylcyclopentylbenzene from the cyclohexylbenzene feed supplied to the oxidation step.

Abstract: In a process for producing phenol and cyclohexanone, a cleavage feed containing greater than 40 wt % and no greater than 95 wt % cyclohexyl-1-phenyl-1-hydroperoxide, and at least 5 wt % and less than 60 wt % cyclohexylbenzene is mixed with at least phenol, cyclohexanone, water, and sulfuric acid to produce a cleavage reaction mixture containing from 15 wt % to 50 wt % phenol, from 15 wt % to 50 wt % cyclohexanone, from 1 wt % to 10 wt % cyclohexyl-1-phenyl-1-hydroperoxide, from 5 wt % to 60 wt % cyclohexylbenzene, from 0.1 wt % to 4 wt % water, and from 10 wppm to 1000 wppm sulfuric acid. The cleavage reaction mixture is then reacted at a temperature from 30° C. and to 70° C., and a pressure of at least 1 atmosphere for a time sufficient to convert at least 50% of said cyclohexyl-1-phenyl-1-hydroperoxide in said cleavage reaction mixture and produce a cleavage effluent containing phenol and cyclohexanone.

Abstract: Disclosed herein is a process for dehydrogenating a hydrocarbon with a dehydrogenation catalyst comprising a step of activating the catalyst precursor in a H2-containing atmosphere. A particularly advantageous activation process includes heating the catalyst precursor to a temperature in a range from 400° C. to 600° C. The process of the present disclosure is particularly advantageous for dehydrogenating cyclohexane to make benzene.

Abstract: In a process for producing phenol and/or cyclohexanone, cyclohexylbenzene is contacted with an oxygen-containing gas in the presence of an oxidation catalyst under oxidation conditions effective to produce an oxidation effluent comprising cyclohexylbenzene hydroperoxide. At least a portion of the oxidation effluent is then subjected to a concentrating step to produce a cleavage feed having a higher concentration of cyclohexylbenzene hydroperoxide than the oxidation effluent. A cleavage reaction mixture comprising the cleavage feed is then contacted with a solid acid catalyst in a cleavage reaction zone under conditions effective to produce a cleavage product comprising phenol and cyclohexanone.