Patents by Inventor Moshe Kotler

Moshe Kotler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELLULAR APOBEC3 PROTEINS AND MODULATORS THEREOF FOR REGULATING DNA REPAIR PROCESSES AND TREATING PROLIFERATIVE DISEASES
    Publication number: 20150111836
    Abstract: The present invention provides methods, compositions and kits for modulating DSB repair processes in a subject in need thereof. More specifically, the invention provides the use of compounds that modulate the expression or activity of at least one APOBEC family member for modulating DSB repair processes.
    Type: Application
    Filed: February 12, 2013
    Publication date: April 23, 2015
    Inventors: Moshe Kotler, Roni Nowarski, Elena Britan-Rosich, Lea Baraz
  • MACROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS FOR PREVENTING OR TREATING HIV INFECTION
    Publication number: 20120270774
    Abstract: The present invention relates to backbone cyclized CD-4 mimetics and to compositions and methods comprising them for preventing and treating viral infection. In particular, the present invention relates to orally bio-available compounds and formulations for prevention and treatment of human HIV-1 infection.
    Type: Application
    Filed: August 29, 2010
    Publication date: October 25, 2012
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem LTd
    Inventors: Chaim Gilon, Amnon Hoffman, Moshe Kotler, Mattan Hurevich, Salim Joubran, Avi Swed
  • Immunizing fish against viral infection
    Patent number: 7351527
    Abstract: The present invention provides the isolated causative agent of the disease affecting Cyprinus carpino and a method for its isolation. The invention further provides avirulent forms, e.g., live-attenuated form, inactivated form and genetically modified forms of the virus which may be used for vaccination of susceptible fish.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: April 1, 2008
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ministry of Agriculture and Rural Development Dept. of Fisheries and Aquaculture
    Inventors: Moshe Kotler, Arnon Dishon, Janette Bishara Shieban, Maya Ilouze, Izhak Bejerano, Ayana Benet, Nissim Chen, Marina Hutoran, Ariel Ronen
  • Immunizing fish against viral infection
    Publication number: 20060013828
    Abstract: The present invention provides the isolated causative agent of the disease affecting Cyprinus carpino and a method for its isolation. The invention further provides avirulent forms, e.g., live-attenuated form, inactivated form and genetically modified forms of the virus which may be used for vaccination of susceptible fish.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 19, 2006
    Inventors: Moshe Kotler, Arnon Dishon, Janette Shieban, Maya Ilouze, Izhak Bejerano, Ayana Benet, Nissim Chen, Marina Hutoran, Ariel Ronen
  • Method of detecting drug resistance
    Publication number: 20040142405
    Abstract: A method for detecting a drug-resistant virus, whose resistance is due to mutations in a viral protease which normally cleaves a substrate into at least two segments. The method comprises providing an electronic transducer having bound thereto a first binding molecule capable of specifically binding a first segment of the substrate and providing a second binding molecule capable of specifically binding a second segment of the substrate, the second binding molecule being capable of bringing about the precipitation of a precipitate on the electronic transducer. Detection of the presence or absence of the precipitate on the electronic transducer indicates the presence or absence of inhibitory activity of the drug. A screening method for potential viral drugs is also disclosed.
    Type: Application
    Filed: January 22, 2003
    Publication date: July 22, 2004
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Lital Alfonta, Immanuel Blumenzweig, Maya Zayats, Lea Baraz, Moshe Kotler, Itamar Willner