Patents by Inventor Moti Harel
Moti Harel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10806698Abstract: A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.Type: GrantFiled: March 6, 2019Date of Patent: October 20, 2020Assignee: Intervet Inc.Inventors: Moti Harel, Swetha Kambalapally
-
Publication number: 20200154702Abstract: The present invention relates to stable bioactive substances and preparation thereof. A preparation method includes dissolving a bioactive material in a solution substantially free of solutes to make a bioactive solution, adsorbing the bioactive solution onto dry polysaccharide particles to make bioactive loaded polysaccharide particles, and drying the bioactive loaded polysaccharide particles.Type: ApplicationFiled: January 24, 2020Publication date: May 21, 2020Inventors: Moti Harel, Qiong Tang, Erin E. Dickey
-
Patent number: 10575545Abstract: Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.Type: GrantFiled: August 28, 2017Date of Patent: March 3, 2020Assignee: Advanced BioNutrition Corp.Inventors: Moti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
-
Publication number: 20190201331Abstract: A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.Type: ApplicationFiled: March 6, 2019Publication date: July 4, 2019Applicant: Intervet Inc.Inventors: Moti HAREL, Swetha KAMBALAPALLY
-
Patent number: 10272036Abstract: A process for selective transvinylation of a reactant carboxylic acid with a reactant vinyl ester to give a product vinyl ester and the corresponding acid of the reactant vinyl ester in the presence of one or more ruthenium catalysts, wherein a) the reactant vinyl ester, the reactant carboxylic acid and the ruthenium catalyst are supplied to a reactor, wherein b) the molar ratio of reactant vinyl ester to reactant carboxylic acid is 1:3 to 3:1, and c) the transvinylation reaction is conducted, d) on completion of the transvinylation reaction, the reactant vinyl ester and the corresponding acid are separated from the reaction mixture by distillation, e) the product vinyl ester is separated by distillation from the bottom product of the distillation, and f) the remaining reaction mixture is recycled into the reactor.Type: GrantFiled: November 20, 2014Date of Patent: April 30, 2019Assignee: Intervet Inc.Inventors: Moti Harel, Swetha Kambalapally
-
Patent number: 10206421Abstract: Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.Type: GrantFiled: September 19, 2016Date of Patent: February 19, 2019Assignee: Advanced BioNutrition Corp.Inventors: Moti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
-
Publication number: 20170354737Abstract: Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.Type: ApplicationFiled: August 28, 2017Publication date: December 14, 2017Applicant: Advanced BioNutrition CorporationInventors: Moti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
-
Patent number: 9731020Abstract: The present invention relates to formulations and methods for stabilizing and protecting of biologic materials during harsh storing and use conditions, wherein the formulations relate to embedded bioactive materials and biologics, including live bacteria, in a protective glassy matrix.Type: GrantFiled: August 11, 2014Date of Patent: August 15, 2017Assignee: Advanced Bionutrition Corp.Inventors: Moti Harel, Roger Drewes, January Scarbrough
-
Patent number: 9693552Abstract: Biodegradable and nutritionally attractive composition comprising biocidal or antibiotic compounds and/or microbes having bio-adhesion and controlled buoyancy properties are selectively fed to an aquatic organism in open or closed water-bodies, and bioactive components are released upon contact with mucosal tissues such as gill, skin or along the digestive tract of the selected aquatic organism.Type: GrantFiled: February 21, 2013Date of Patent: July 4, 2017Assignee: ADVANCED BIONUTRITION CORPORATIONInventors: Moti Harel, Brian Carpenter, Pete Schmalz
-
Patent number: 9687449Abstract: A delivery vehicle for bioactive agents and live probiotic microbes to aquatic animals protects the bioactive compounds and microbes from digestion and destruction in the animal stomach. It provides for controlled release of bioactive agents and live probiotic microbes to aquatic animals in the form of dry or wet beadlets with essential nutrients and attractants bound with soluble starch and cross-linked alginate. The bioactive agents and live probiotic microbes can be bound with emulsified high-amylose starch and embedded in the beadlets in the form of microparticles.Type: GrantFiled: November 6, 2003Date of Patent: June 27, 2017Assignee: Advanced Bionutrition Corp.Inventor: Moti Harel
-
Patent number: 9623094Abstract: The invention relates to a composition and a method for manufacturing semi-dry or dry particles containing a mucoadhesive polymer and a bioactive agent such as, but not limited to, an Immunogenic Substance (e.g., a vaccine), that allows the oral or nasal administration and delivery of the bioactive agent essentially unaltered to mucosal surfaces in the animal, including an aquatic animal.Type: GrantFiled: March 26, 2010Date of Patent: April 18, 2017Assignee: Advanced BioNutrition CorporationInventors: Moti Harel, Brian Carpenter
-
Publication number: 20170000892Abstract: Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.Type: ApplicationFiled: September 19, 2016Publication date: January 5, 2017Applicant: Advanced BioNutrition CorporationInventors: Moti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
-
Patent number: 9504275Abstract: The present invention includes compositions and drying methods for preserving sensitive bioactive materials, such as peptides, proteins, hormones, nucleic acids, antibodies, drugs vaccines, yeast, bacteria (probiotic or otherwise), viruses and/or cell suspensions, in storage. The compositions include a carbohydrates component and a glass enhancer component, wherein the carbohydrate component includes a mixture of di-, oligo- and polysaccharides and the glass enhancer includes ions of organic acid and protein hydrolysates. The composition is prepared by dispersing all the solid components in a solution and then snap-frozen to form small beads, strings or droplets. The preferred drying method of the frozen beads, strings or droplets is initiated by a short purging and structure stabilizing step of the frozen particles under a vacuum pressure of less than <2000 mTORR followed by a primary drying step under vacuum pressure of more than >2000 mTORR and at a desired temperature.Type: GrantFiled: August 12, 2011Date of Patent: November 29, 2016Assignee: Advanced BioNutrition CorporationInventors: Moti Harel, Qiong Tang
-
Patent number: 9504750Abstract: Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.Type: GrantFiled: March 25, 2013Date of Patent: November 29, 2016Assignee: ADVANCED BIONUTRITION CORPORATIONInventors: Moti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
-
Patent number: 9480276Abstract: The disclosure relates to a probiotic delivery system that can be consumed as a snack-food or added to a food product. In particular, the disclosure describes a crisp and tasty treat that comprises viable probiotic microorganisms preserved in a vacuum dried matrix of sugars, proteins, and polysaccharides. The probiotic remain viable within the treat for a longer time without the need for additional moisture barrier coating. The probiotic also remain viable in the animal gastrointestinal tract.Type: GrantFiled: September 8, 2014Date of Patent: November 1, 2016Assignee: Advanced Bionutrition CorporationInventors: Moti Harel, Alicia Bennett
-
Publication number: 20160296469Abstract: A process for selective transvinylation of a reactant carboxylic acid with a reactant vinyl ester to give a product vinyl ester and the corresponding acid of the reactant vinyl ester in the presence of one or more ruthenium catalysts, wherein a) the reactant vinyl ester, the reactant carboxylic acid and the ruthenium catalyst are supplied to a reactor, wherein b) the molar ratio of reactant vinyl ester to reactant carboxylic acid is 1:3 to 3:1, and c) the transvinylation reaction is conducted, d) on completion of the transvinylation reaction, the reactant vinyl ester and the corresponding acid are separated from the reaction mixture by distillation, e) the product vinyl ester is separated by distillation from the bottom product of the distillation, and f) the remaining reaction mixture is recycled into the reactor.Type: ApplicationFiled: November 20, 2014Publication date: October 13, 2016Applicant: ADVANCED BIONUTRITION CORPORATIONInventors: MOTI HAREL, SWETHA KAMBALAPALLY
-
Patent number: 9445613Abstract: The present invention relates to microparticles and methods of making such microparticles that protect a bioactive substance from heat, humidity and oxidation. A microparticle comprising a bioactive substance, an agglomerating agent, an emulsifier and solid fats is disclosed. A method to produce a microparticle comprising an agglomerated bioactive substance enrobed in a double layer of solid fats and emulsifier is also disclosed.Type: GrantFiled: March 24, 2010Date of Patent: September 20, 2016Assignee: ADVANCED BIONUTRITION CORPORATIONInventor: Moti Harel
-
Patent number: 9205151Abstract: A composition comprising a drug or pharmaceutically active agent and a bioadhesive delivery system provides for the oral delivery of a vaccine to animals, particularly aquatic animals.Type: GrantFiled: June 16, 2014Date of Patent: December 8, 2015Assignee: ADVANCED BIONUTRITION CORPORATIONInventors: Moti Harel, Brian Carpenter
-
Publication number: 20150265638Abstract: A method of preparing a feed composition includes (a) mixing one or more carotenoids and one or more phospholipids in an organic solvent to form a solution; and (b) thereafter combining the carotenoid(s) and phospholipid(s) with at least one other animal feed component. The organic solvent is a polar solvent selected from the group consisting of chlorocarbons and lower alcohols, and step (a) further includes removing the polar solvent from the solution.Type: ApplicationFiled: April 29, 2015Publication date: September 24, 2015Applicant: ADVANCED BIONUTRITION CORPORATIONInventors: MOTI HAREL, John Piechocki, David J. Kyle
-
Patent number: 9072311Abstract: Carotenoids are provided as dietary supplements to animal feed. These supplements improve the bioavailability of carotenoids by providing them in combination with phospholipids. The invention provides animal feeds for aquatic and terrestrial animals, and methods for making the feeds.Type: GrantFiled: June 21, 2004Date of Patent: July 7, 2015Assignee: ADVANCED BIONUTRITION CORPORATIONInventors: Moti Harel, John Piechocki, David J. Kyle