Patents by Inventor Motoi Oishi

Motoi Oishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEG-functional nucleic acid conjugate
    Patent number: 7642343
    Abstract: The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: January 5, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki, Fumi Nagatsugi, Motoi Oishi
  • Blood Retainable Device Exhibiting Selective Degradability in Tumor Tissue
    Publication number: 20090022782
    Abstract: A phospholipid derivative useful for the preparation of liposomes for efficient uptake of an antitumor agent or a gene intracellularly by a target tumor cell, which comprises a residue of an alcohol compound and a residue of a phospholipid, and comprising a peptide between the residue of an alcohol compound and the residue of a phospholipid, and wherein (a) the alcohol compound is an alcohol compound selected from poly(alkylene glycols) and the like, (b) the phospholipid is a phospholipid selected from phosphatidylethanolamines, phosphatidylcholines, phosphatidylserines and the like, and (c) the peptide is a peptide comprising a substrate peptide that can serve as a substrate of a matrix metalloproteinase, provided that one amino acid residue or an oligopeptide containing 2 to 8 amino acid residues may bind to one or both ends of the substrate peptide.
    Type: Application
    Filed: February 24, 2006
    Publication date: January 22, 2009
    Applicants: NATIONAL UNIVERSITY CORP. HOKKAIDO UNIVERSITY, UNIVERSITY OF TSUKUBA
    Inventors: Hidetaka Akita, Hiroto Hatakeyama, Yukio Nagasaki, Hiroshi Kikuchi, Hideo Kobayashi, Hideyoshi Harashima, Motoi Oishi
  • Peg-functional nucleic acid conjugate
    Publication number: 20080097087
    Abstract: The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
    Type: Application
    Filed: April 14, 2005
    Publication date: April 24, 2008
    Inventors: Yukio Nagasaki, Kazunori Kataoka, Shigeki Sasaki, Fumi Nagatsugi, Motoi Oishi
  • Conjugate of Peo and Double Stranded Nucleic Acid
    Publication number: 20080064863
    Abstract: A polyion complex is provided, comprising a double stranded nucleic acid containing a poly(ethylene oxide)-modified oligo- or poly-nucleotide and a polycationic compound, which is an effective delivery means of a gene to a target cell.
    Type: Application
    Filed: August 24, 2005
    Publication date: March 13, 2008
    Inventors: Yukio Nagasaki, Kazunori Kataoka, Motoi Oishi