Patents by Inventor Mouad Alami

Mouad Alami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN
    Publication number: 20170035761
    Abstract: The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.
    Type: Application
    Filed: April 9, 2015
    Publication date: February 9, 2017
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD
    Inventors: Mouad ALAMI, Jean-Daniel BRION, Samir MESSAOUDI, Olivier PROVOT, Mohamed-Ali SOUSSI, Jerome BIGNON, Joelle DUBOIS, Joanna BAKALA-WDZIECZAK
  • PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20130203718
    Abstract: The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.
    Type: Application
    Filed: May 9, 2011
    Publication date: August 8, 2013
    Inventors: Marie-Edith Rafestin-Oblin, Mouad Alami, Hugues Loosfelt, Abdallah Hamze, Ali Junaid Khan, Abdellatif Tikad, Marc Lombes, Jean-Daniel Brion
  • Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization
    Patent number: 8273768
    Abstract: The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: September 25, 2012
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Mouâd Alami, Jean-Daniel Brion, Olivier Provot, Jean-François Peyrat, Samir Messaoudi, Abdallah Hamze, Anne Giraud, Jérôme Bignon, Joanna Bakala, Jian-Miao Liu
  • DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION
    Publication number: 20110160228
    Abstract: The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
    Type: Application
    Filed: June 4, 2009
    Publication date: June 30, 2011
    Inventors: Mouâd Alami, Samir Messaoudi, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Jian-Miao Liu, Jérôme Bignon, Joanna Bakala
  • ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION
    Publication number: 20100129471
    Abstract: The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
    Type: Application
    Filed: April 4, 2008
    Publication date: May 27, 2010
    Inventors: Mouâd Alami, Jean-Daniel Brion, Olivier Provot, Jean-François Peyrat, Samir Messaoudi, Abdallah Hamze, Anne Giraud, Jérôme Bignon, Joanna Bakala, Jian-Miao Liu
  • Method for preparing 4-methyl-biphenyl derivatives
    Patent number: 6407253
    Abstract: The subject-matter of the invention is a process for the preparation of substituted 4-methylbiphenyls of general formula: in which R is a cyano group or a protected tetrazolyl group of formula: in which R1, situated at the 1 or 2 position of the tetrazolyl group, is a protective group, characterized in that a halobenzene of formula: in which Hal is a halogen atom and R has the same meaning as above, is reacted with a p-tolylmagnesium halide in the presence of a linear or branched polyether and of a catalyst comprising a transition metal.
    Type: Grant
    Filed: July 14, 1999
    Date of Patent: June 18, 2002
    Assignee: Sanofi-Synthelabo
    Inventors: Mouad Alami, Gérard Cahiez, Bertrand Castro, Jean-Robert Dormoy, Eric Riguet
  • Process for the preparation of a cyanobiphenyl
    Patent number: 6392080
    Abstract: The subject-matter of the invention is a process for the preparation of o-(p-tolyl)benzonitrile, characterized in that an o-halobenzonitrile is treated with a p-tolylmagnesium halide in the presence of a manganous salt and of a cocatalyst comprising a transition metal.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: May 21, 2002
    Assignee: Sanofi-Stnth{dot over (e)}labo
    Inventors: Mouad Alami, Gérard Cahiez, Bertrand Castro, Eric Riguet