Abstract: Provided herein are, inter alia, compositions, methods, and systems for selectively modulating an activity of CRISPR-based systems, including CRISPR-based genome editing systems and CRISPR-based gene regulation in a target cell. Also provided are compositions, methods, and systems for controlling a gene regulation circuit or building dynamic pulsatile gene regulation circuits in a target cell, e.g., a mammalian cell by using CRISPR-based genome editing tools.

Abstract: To provide a surface structure of an aluminum-based member which can further improve heat insulating properties and heat shielding properties of the aluminum-based member. In an aluminum-based member 1 containing at least a silicon composition, a porous oxide film 2 is provided on a surface of the aluminum-based member 1, and the oxide film 2 is constituted to have at least a pore 2a extending from the surface toward an inside in a thickness direction of the oxide film 2 and a void 3a present inside the silicon composition 3 extending in a direction substantially orthogonal to the thickness direction of the oxide film 2.

Abstract: To provide a surface structure of an aluminum-based member which can further improve heat insulating properties and heat shielding properties of the aluminum-based member. In an aluminum-based member 1 containing at least a silicon composition, a porous oxide film 2 is provided on a surface of the aluminum-based member 1, and the oxide film 2 is constituted to have at least a pore 2a extending from the surface toward an inside in a thickness direction of the oxide film 2 and a void 3a present inside the silicon composition 3 extending in a direction substantially orthogonal to the thickness direction of the oxide film 2.

Abstract: To provide an SPR sensor plate which allows easy fixation of an antibody and easy retention of a subject and which can be manufactured easily, as well as an immune reaction measuring instrument employing this SPR sensor plate. The SPR sensor plate includes: a plate-shaped light waveguide 3 that allows light from a light source 21 to be transmitted therethrough; and a sensing metal film 5 formed on part of a surface of the light waveguide 3. A reflecting metal film 7 is formed on opposite end surfaces of the light waveguide 3 except for a light incident surface 9 and a light exit surface 11 forming inclined surfaces having a same inclination.

Abstract: An SPR (surface plasmon resonance) sensor cell comprising: a light-transparent core; a clad covering the core and having a through hole at a predetermined position to communicate with the core; and a predetermined thin metal film formed on an exposed surface of the core corresponding to the through hole.

Abstract: To provide an SPR sensor plate which allows easy fixation of an antibody and easy retention of a subject and which can be manufactured easily, as well as an immune reaction measuring instrument employing this SPR sensor plate. The SPR sensor plate includes: a plate-shaped light waveguide 3 that allows light from a light source 21 to be transmitted therethrough; and a sensing metal film 5 formed on part of a surface of the light waveguide 3. A reflecting metal film 7 is formed on opposite end surfaces of the light waveguide 3 except for a light incident surface 9 and a light exit surface 11 forming inclined surfaces having a same inclination.

Abstract: An immunoassay apparatus comprising: at least two optical fibers, each having a first end serving as an SPR sensor; a light source for emitting a predetermined light to a second end of said optical fibers; a spectrometer for analyzing a wavelength distribution of a reflected light reflected by the SPR sensors; a main control block for controlling operation of the light source and the spectrometer; and an apparatus main body for containing the aforementioned components.