Patents by Inventor Murali K. Pasumarthy

Murali K. Pasumarthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lyophilizable and enhanced compacted nucleic acids
    Patent number: 8017577
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body. Moreover, counterions such as acetate can protect compacted nucleic acid complexes from adverse effects of lyophilization.
    Type: Grant
    Filed: September 8, 2003
    Date of Patent: September 13, 2011
    Assignee: Copernicus Therapeutics, Inc.
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello
  • Lyophilizable and enhanced compacted nucleic acids
    Publication number: 20040048787
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body.
    Type: Application
    Filed: September 8, 2003
    Publication date: March 11, 2004
    Applicant: Copernicus Therapeutics, Inc.
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello
  • Lyophilizable and enhanced compacted nucleic acids
    Publication number: 20030171322
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body.
    Type: Application
    Filed: December 2, 2002
    Publication date: September 11, 2003
    Applicant: Copernicus Therapeutics, Inc.
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello
  • Lyophilizable and enhanced compacted nucleic acids
    Publication number: 20030134818
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body.
    Type: Application
    Filed: December 2, 2002
    Publication date: July 17, 2003
    Applicant: Copernicus Therapeutics, Inc.
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello
  • Lyophilizable and enhanced compacted nucleic acids
    Publication number: 20030078229
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body.
    Type: Application
    Filed: November 27, 2002
    Publication date: April 24, 2003
    Applicant: Copernicus Therapeutics, Inc.
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello
  • Lyophilizable and enhanced compacted nucleic acids
    Publication number: 20030078230
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body.
    Type: Application
    Filed: November 27, 2002
    Publication date: April 24, 2003
    Applicant: Copernicus Therapeutics, Inc.
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello
  • Lyophilizable and enhanced compacted nucleic acids
    Publication number: 20020042388
    Abstract: Counterions of polycations used to compact nucleic acids profoundly affect shape and stability of particles formed. Shape is associated with differential serum nuclease resistance and colloidal stability. A surrogate for determining such properties that is easy to measure is the turbidity parameter. Shape also affects the suitability and efficacy of compacted nucleic acid complexes for transfecting cells by various routes into a mammalian body.
    Type: Application
    Filed: May 31, 2001
    Publication date: April 11, 2002
    Inventors: Mark J. Cooper, Murali K. Pasumarthy, Tomasz H. Kowalczyk, Maureen Costello