Patents by Inventor Murali Krishna Prasad Divi

Murali Krishna Prasad Divi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for isomerisation of lycopene in the presence of thiourea
    Patent number: 8389790
    Abstract: The present invention relates to isomerization of Z-lycopene in mixtures of isomers to mixtures enriched with all E-lycopene.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: March 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Ramesh Babu Kodali
  • Process for the preparation of (R,S)-nicotine
    Patent number: 8389733
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpynolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: March 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the preparation of (R, S)-nicotine
    Patent number: 8378110
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: February 19, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the resolution of (R,S)-nicotine
    Patent number: 8378111
    Abstract: (R,S)-Nicotine was resolved through diastereomeric salt formation using dibenzoyl-d-tartaric acid and dibenzoyl-l-tartaric acid to obtain enantiomerically pure (S)-nicotine and (R)-nicotine.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: February 19, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the preparation of (R,S)-nicotine
    Patent number: 8367837
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: February 5, 2013
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20130030187
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpynolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20130030188
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl) pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: October 8, 2012
    Publication date: January 31, 2013
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20120330008
    Abstract: A novel process is described for the preparation of pharmaceutically useful compounds such as 1-{4-[2-(azepan-1-yl)ethoxy]benzyl}-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid commonly known as bazedoxifene acetate of the formula-1 using 2-(4-{[5-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-methyl-1H-indol-1-yl]methyl}phenoxy)ethyl-4-methylbenzenzene-1-sulfonate (formula 2a)
    Type: Application
    Filed: September 8, 2011
    Publication date: December 27, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Bolneni Nageswara Rao, Dandu Venkata Suresh
  • PREPARATION OF 2-(4-BROMOPHENYL)-2-METHYLPROPANOIC ACID
    Publication number: 20120309973
    Abstract: Selective bromination of 2-methyl-2-phenylpropanoic acid in aqueous medium is described to obtain pure 2-(4-bromophenyl)-2-methylpropanoic acid, which is a useful key intermediate in the process of manufacturing pure fexofenadine.
    Type: Application
    Filed: August 29, 2011
    Publication date: December 6, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Krishnaji Rao Mutyala
  • PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE tert-LEUCINE
    Publication number: 20120245379
    Abstract: Enantiomerically pure L-tert-leucine and D-tert-leucine were prepared from (DL)-tert-leucine by diastereomeric salt formation using dibenzoyl-d-tartaric acid as the resolving agent.
    Type: Application
    Filed: June 7, 2011
    Publication date: September 27, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin
  • PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
    Publication number: 20120209006
    Abstract: A process for (R,S)-nicotine is described. Condensation of 1-(but-1-enyl)pyrrolidin-2-one with nicotinic acid ester gave 1-(but-1-enyl)-3-nicotinoylpyrrolidin-2-one which on treatment with an acid and a base gave myosmine. Myosmine was converted to (R,S)-nicotine by reduction followed by N-methylation.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 16, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • PROCESS FOR ISOMERISATION OF LYCOPENE IN THE PRESENCE OF THIOUREA
    Publication number: 20120197055
    Abstract: The present invention relates to isomerization of Z-lycopene in mixtures of isomers to mixtures enriched with all E-lycopene.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 2, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Ramesh Babu Kodali
  • PROCESS FOR THE RESOLUTION OF (R,S)-NICOTINE
    Publication number: 20120197022
    Abstract: (R,S)-Nicotine was resolved through diastereomeric salt formation using dibenzoyl-d-tartaric acid and dibenzoyl-l-tartaric acid to obtain enantiomerically pure (S)-nicotine and (R)-nicotine.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 2, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Hari Babu Katta
  • Process for the preparation of pregabalin
    Patent number: 8212072
    Abstract: The present invention provides a new enantioselective method of preparing (S)-3-(aminomethyl)-5-methylhexanoic acid, commonly known as pregabalin. The invention also provides new chiral intermediates useful in the production of pregabalin.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: July 3, 2012
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandala, Mysore Aswatha Narayana Rao, Srinivasan Subramanian Kuduva
  • PROCESS FOR RESOLUTION OF 1-(3-HYDROXYPHENYL)-2-METHYLAMINO ETHANOL
    Publication number: 20120108848
    Abstract: Resolution of the title compound to its active isomer (R)-1-(3-hydroxyphenyl)-2-methylamino ethanol with (R)-naproxen as a resolving agent.
    Type: Application
    Filed: December 22, 2010
    Publication date: May 3, 2012
    Applicant: Divi's Laboratories Limited
    Inventors: Murali Krishna Prasad Divi, Padakandla Gundu Rao, Bolneni Nageswara Rao, Medepudi Ramesh Babu, Mutyala Krishnaji Rao, Allupati Padmanav Patro
  • Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline
    Patent number: 8148527
    Abstract: The resolution of racemic 1-(4-methoxybenzyl)-octahydro-isoquinoline, a key intermediate in the synthesis of the antitussive agent dextromethorphan, is reported using (R)-2-(6-methoxy-2-naphthyl) propionic acid in good yields. The resolving agent and the undesired isomer of the octahydro-isoquinoline have been recovered in good yield.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: April 3, 2012
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Srinivas Rao Pendyala, Lavu Venkata Ramana
  • PROCESS FOR THE PREPARATION OF PREGABALIN
    Publication number: 20120041212
    Abstract: The present invention provides a new enantioselective method of preparing (S)-3-(aminomethyl)-5-methylhexanoic acid, commonly known as pregabalin. The invention also provides new chiral intermediates useful in the production of pregabalin.
    Type: Application
    Filed: January 3, 2011
    Publication date: February 16, 2012
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Srinivasan Subramanian Kuduva
  • Process for the preparation of irbesartan
    Patent number: 8080670
    Abstract: The present invention relates to a process for the preparation of 2-butyl-3-[[2?-(1H-tetrazol-5-yl)[1,1?-biphenyl]-4-yl]-1,3-diazaspiro[4,4]non-1-en-4-one by reaction of the corresponding nitrile with sodium azide and piperazine or its acid salt.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: December 20, 2011
    Assignee: Divi's Laboratories, Ltd.
    Inventors: Murali Krishna Prasad Divi, Mysore Aswatha Narayana Rao, Surendra Kalyan Nuthi, Yugandar Phaniram Bandaru
  • PROCESS FOR THE PREPARATION OF GABAPENTIN
    Publication number: 20110306787
    Abstract: This invention discloses a process for converting gabapentin acid salt to free gabapentin, where the salt is dissolved in an organic solvent in which both gabapentin acid salt and free gabapentin are soluble. The solution is treated with a powdered alkaline base to liberate free gabapentin which will remain in solution. The insoluble alkali salt of the acid is removed by filtration. From the filtrate free gabapentin is obtained either by adding anti-solvent or by extraction with water.
    Type: Application
    Filed: December 14, 2010
    Publication date: December 15, 2011
    Applicant: DIVI'S LABORATORIES LIMITED
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Mysore Aswatha Narayana Rao, Shaik Nowshuddin, Maddipati Prasad
  • PROCESS FOR THE PREPARATION OF IRBESARTAN
    Publication number: 20110275828
    Abstract: The present invention relates to a process for the preparation of 2-butyl-3-[[2?-(1H-tetrazol-5-yl)[1,1?-biphenyl]-4-yl]-1,3-diazaspiro[4,4]non-1-en-4-one by reaction of the corresponding nitrile with sodium azide and piperazine or its acid salt.
    Type: Application
    Filed: June 21, 2010
    Publication date: November 10, 2011
    Applicant: DIVI'S LABORATORIES LTD.
    Inventors: Murali Krishna Prasad DIVI, Mysore Aswatha Narayana RAO, Surendra Kalyan NUTHI, Yugandar Phaniram BANDARU