Patents by Inventor Murthy Simhambhatla
Murthy Simhambhatla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8821473Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.Type: GrantFiled: December 7, 2009Date of Patent: September 2, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyaz Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
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Patent number: 8747385Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.Type: GrantFiled: May 10, 2012Date of Patent: June 10, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyez Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
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Patent number: 8652194Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: GrantFiled: March 23, 2006Date of Patent: February 18, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
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Patent number: 8613764Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: GrantFiled: January 31, 2008Date of Patent: December 24, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
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Patent number: 8383158Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.Type: GrantFiled: April 15, 2003Date of Patent: February 26, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyez Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
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Publication number: 20100144635Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.Type: ApplicationFiled: December 7, 2009Publication date: June 10, 2010Applicant: Abbott Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Ni Ding, Murthy Simhambhatla, Syed Faiyaz Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
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Patent number: 7641643Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.Type: GrantFiled: April 15, 2003Date of Patent: January 5, 2010Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Evgenia Mandrusov, Charles D. Claude, Nadine Ding, Murthy Simhambhatla, Syed Faiyez Ahmed Hossainy, Srinivasan Sridharan, Paul Consigny
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Patent number: 7470469Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality. The functionalities can be carboxylate, amine, or sulfate groups and/or polyethylene glycol and can optionally include crosslinking groups.Type: GrantFiled: July 5, 2007Date of Patent: December 30, 2008Assignee: Advanced Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Murthy Simhambhatla, Charles D. Claude
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Publication number: 20080125851Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: ApplicationFiled: January 31, 2008Publication date: May 29, 2008Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
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Patent number: 7326238Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.Type: GrantFiled: September 30, 2002Date of Patent: February 5, 2008Assignee: Abbott Cardiovascular Systems Inc.Inventors: Deborah Kilpatrick, Murthy Simhambhatla, Santosh Prabhu, Shawn Chin Quee
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Patent number: 7311970Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.Type: GrantFiled: September 17, 2004Date of Patent: December 25, 2007Assignee: Abbott Cardiovascular Systems Inc.Inventors: Eugene T. Michal, Murthy Simhambhatla, Charles D. Claude
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Publication number: 20070190103Abstract: The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics.Type: ApplicationFiled: February 10, 2006Publication date: August 16, 2007Inventors: Syed Hossainy, Stephen Pacetti, Murthy Simhambhatla
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Publication number: 20070110787Abstract: Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings.Type: ApplicationFiled: December 21, 2006Publication date: May 17, 2007Inventors: Syed Hossainy, Murthy Simhambhatla
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Publication number: 20060265043Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.Type: ApplicationFiled: March 24, 2006Publication date: November 23, 2006Inventors: Evgenia Mandrusov, Deborah Kilpatrick, Murthy Simhambhatla, Syed Hossainy, Jessica Chiu, Mina Chow, Eugene Michal, Charles Claude, William Webler
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Publication number: 20060135943Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.Type: ApplicationFiled: November 17, 2005Publication date: June 22, 2006Inventors: Evgenia Mandrusov, Deborah Kilpatrick, Murthy Simhambhatla, Syed Hossainy
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Publication number: 20060062821Abstract: Polycationic peptide coatings for implantable medical devices and methods of making the same are described. The methods include applying an emulsion on the device, the emulsion including a polymer and a polycationic peptide. Other methods include incorporation of the polycationic peptide in microspheres and liposomes.Type: ApplicationFiled: September 2, 2005Publication date: March 23, 2006Inventors: Murthy Simhambhatla, Ni Ding, Stephen Pacetti
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Patent number: 7008411Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.Type: GrantFiled: September 30, 2002Date of Patent: March 7, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Evgenia Mandrusov, Deborah Kilpatrick, Murthy Simhambhatla, Syed Hossainy
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Publication number: 20050222584Abstract: A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.Type: ApplicationFiled: May 26, 2005Publication date: October 6, 2005Inventors: Deborah Kilpatrick, Robert Ainsworth, Murthy Simhambhatla, Jeong Lee
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Publication number: 20050031874Abstract: A medical device comprising a substrate having a plasma polymerized functionality bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.Type: ApplicationFiled: September 17, 2004Publication date: February 10, 2005Inventors: Eugene Michal, Murthy Simhambhatla, Charles Claude
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Publication number: 20050003011Abstract: A method including forming a pseudo-gel of a semi-crystalline polymer material and a solvent. The pseudo-gel is shaped into a first form and stretched. A portion of the solvent is removed to create a second form. The second form is stretched into a microstructure including nodes interconnected by fibrils. A method including forming a first form of a pseudo-gel including an ultra-high molecular weight polyethylene material and a solvent; stretching the first form; removing the solvent to form a second form; stretching the second form into a microstructure including nodes interconnected by fibrils; and annealing the stretched second form. An apparatus including a body portion formed of a dimension suitable for a medical device application and including a polyolefin polymer including a node and a fibril microstructure. An apparatus including a body portion including an ultra-high molecular weight polyolefin material including a node and a fibril microstructure.Type: ApplicationFiled: July 15, 2004Publication date: January 6, 2005Inventors: Srinivasan Sridharan, Murthy Simhambhatla